Construction and validation of prognostic signatures related to mitochondria and macrophage polarization in gastric cancer
Yan Zhang,
Jian Cao,
Zhen Yuan
et al.
Abstract:BackgroundIncreasing evidence reveals the involvement of mitochondria and macrophage polarisation in tumourigenesis and progression. This study aimed to establish mitochondria and macrophage polarisation-associated molecular signatures to predict prognosis in gastric cancer (GC) by single-cell and transcriptional data.MethodsInitially, candidate genes associated with mitochondria and macrophage polarisation were identified by differential expression analysis and weighted gene co-expression network analysis. Su… Show more
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