2021
DOI: 10.3390/ijms22041539
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Abstract: In a previous study, the whole transcriptome of the vastus lateralis muscle from sedentary elderly and from age-matched athletes with an exceptional record of high-intensity, life-long exercise training was compared—the two groups representing the two extremes on a physical activity scale. Exercise training enabled the skeletal muscle to counteract age-related sarcopenia by inducing a wide range of adaptations, sustained by the expression of protein-coding genes involved in energy handling, proteostasis, cytos… Show more

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Cited by 15 publications
(16 citation statements)
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“…This may result in higher muscle mass and mitochondrial dynamics in skeletal muscle [141,142]. Additionally, higher expression of MALAT1 in muscles after regular exercise was described [105]. Apart from its role in myogenic differentiation, i.e., modulation of MYOD transcriptional activity, it was shown that MALAT1 influences synapse formation by regulating the expression of genes involved in synaptogenesis, e.g., NLG1 encoding NEUROLIGIN1 and CADM1 [143].…”
Section: Expression Of Lncrnas In Muscle Tissue After Resistance or Endurance Trainingmentioning
confidence: 98%
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“…This may result in higher muscle mass and mitochondrial dynamics in skeletal muscle [141,142]. Additionally, higher expression of MALAT1 in muscles after regular exercise was described [105]. Apart from its role in myogenic differentiation, i.e., modulation of MYOD transcriptional activity, it was shown that MALAT1 influences synapse formation by regulating the expression of genes involved in synaptogenesis, e.g., NLG1 encoding NEUROLIGIN1 and CADM1 [143].…”
Section: Expression Of Lncrnas In Muscle Tissue After Resistance or Endurance Trainingmentioning
confidence: 98%
“…Thus far, the exact molecular mechanisms responsible for body adaptation to exercise have not been defined. However, it seems that physical activity can regulate the expression of various genes by affecting DNA methylation [99], histone modifications [100], miRNA, or lncRNA expression [101][102][103][104][105]. Analyses of material obtained from human skeletal muscle biopsies or body fluids have shown that various training protocols and body adaptations differently impact miRNA and lncRNA levels.…”
Section: Physical Activity Impact On Mirna and Lncrnamentioning
confidence: 99%
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“… 121 In a further study, differentially expressed ncRNAs and miRNAs in muscle atrophy were induced by long-term inactivity mainly involved in cell-cycle regulation, cytoskeleton control, and an AMP-activated protein kinase (AMPK) pathway. 122 …”
Section: Ncrnas In Muscle Atrophy Induced By Unhealthy Habitsmentioning
confidence: 99%
“…Exercise has enabled skeletal muscle to counteract age-related sarcopenia by inducing a wide range of adaptations, supported by the expression of genes encoding proteins involved in energy management, proteostasis, cytoskeletal organisation, control of inflammation and cellular senescence. De Sanctis et al [10] had previously examined the entire transcriptome of the vastus lateralis muscle of sedentary elderly and similarly aged athletes with an exceptional record of high-intensity, lifelong training. In this paper, the authors describe the network of differentially expressed non-coding RNAs in the two classes and some of their possible targets and roles (Figure 2).…”
mentioning
confidence: 99%