Non-coding RNAs in immunoregulation and autoimmunity: Technological advances and critical limitations

Kumar, Dhaneshwar; Sahoo, Subhransu S.; Chauss, Daniel; Kazemian, Majid; Afzali, Behdad

doi:10.1016/j.jaut.2022.102982

Cited by 10 publications

(5 citation statements)

References 374 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the application of circRNAs in clinical settings still requires further research, including how to construct more efficient and specific carriers for the delivery of circRNAs to specific cells or tissues. Additionally, it is important to clarify circRNAs’ pharmacokinetics, biodistribution in the body, and adverse reactions ( 116 ).…”

Section: Discussionmentioning

confidence: 99%

“…Evidently, non-coding RNAs (ncRNAs) can effectively modulate the proliferation, migration, and invasion capacities of RA-FLSs through various pathways and targets, thus contributing to the reduction of irreversible damage to joint cartilage and bone ( 167 ). Moreover, drugs specifically tailored to target the biological functions of RA-FLS can be locally administered, enabling higher drug concentrations and prolonged therapeutic durations, which enhances treatment efficacy while reducing systemic drug distribution, thereby minimizing adverse effects on other tissues and organs ( 116 , 171 ). This comprehensive therapeutic strategy represents a promising avenue for RA management.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Current situation and trend of non-coding RNA in rheumatoid arthritis: a review and bibliometric analysis

Wei,

Li,

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

BackgroundRheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that affects multiple joints and has adverse effects on various organs throughout the body, often leading to a poor prognosis. Recent studies have shown significant progress in the research of non-coding RNAs (ncRNAs) in RA. Therefore, this study aims to comprehensively assess the current status and research trends of ncRNAs in RA through a bibliometric analysis.MethodsThis study retrieved articles relevant to ncRNAs and RA from the Science Citation Index Expanded Database of the Web of Science Core Collection between January 1st, 2003, and July 31st, 2023. The relevant articles were screened based on the inclusion criteria. VOSviewer and CiteSpace are utilized for bibliometric and visual analysis.ResultsA total of 1697 publications were included in this study, and there was a noticeable increase in annual publications from January 1st, 2003, to July 31st, 2023. China, the United States, and the United Kingdom were the most productive countries in this field, contributing to 43.81%, 13.09%, and 3.87% of the publications. Anhui Medical University and Lu Qianjin were identified as the most influential institution and author. Frontiers In Immunology stood out as the most prolific journal, while Arthritis & Rheumatology was the most co-cited journal. Additionally, the research related to “circular RNA”, “oxidative stress”, “proliferation”, and “migration” have emerged as new hotspots in the field.ConclusionIn this study, we have summarized the publication characteristics related to ncRNA and RA and identified the most productive countries, institutions, authors, journals, hot topics, and trends.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Current situation and trend of non-coding RNA in rheumatoid arthritis: a review and bibliometric analysis

Wei,

Li,

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Some of these papers barely mentioned circRNA, 64,[86][87][88][89][90][91][92] while others focused on other types of ncRNAs such as miRNA and LncRNA. 93,94 A few papers discussed the role of circRNA in other types of diseases but did not mention MS. [95][96][97][98] The lack of comprehensive discussion on the role of circRNA in MS and other diseases may be attributed to the limited understanding of this molecule. Further research is needed to fully elucidate the functions of circRNA in health and disease, particularly in the context of complex diseases such as MS.…”

Section: Discussionmentioning

confidence: 99%

Circular RNA in Multiple Sclerosis: Pathogenicity and Potential Biomarker Development: A Systematic Review

Mohammed

2023

Genet Epigenet

View full text Add to dashboard Cite

Multiple sclerosis (MS) is a complex autoimmune disorder of the CNS that affects millions of people worldwide. The causes of the disease remain unknown despite extensive efforts to understand it. CircRNAs are a unique class of endogenous non-coding RNA that are abundant, stable, conserved, and specifically expressed molecules, making them a promising biomarker of diseases. This review investigates the role of circRNA in MS pathogenicity and their potential as a biomarker through a comprehensive literature search conducted in 8 scientific databases. The studies found that there are differentially expressed circRNAs in MS patients compared to healthy controls (HC), and this difference is even more pronounced in different MS subtypes. Enrichment of circRNAs in linkage disequilibrium (LD) blocks that harbor MS-associated SNPs suggests that these SNPs manipulate the levels of circRNAs in the surrounding area, contributing to disease pathogenicity. While circRNA shows promise as an indicator or biomarker for MS disease pathology, further research is needed to fully explore its potential and impact on human biology.

show abstract

“…The expression profiles of ncRNAs vary depending on the kind of cell, the stage of development, and the physiological conditions to which the cells are exposed ( 52 ). This holds true even for immune system cells; fluctuations in the expression levels of ncRNAs in immune cells have been observed in various conditions, such as cancer, inflammation, and autoimmune diseases ( 53 , 54 ). ncRNAs are regulators of immune system function because of their ability to alter gene expression in immune cells.…”

Section: Methodsmentioning

confidence: 99%

The landscape of non-coding RNAs in the immunopathogenesis of Endometriosis

Abbaszadeh,

Karimi,

Rajaei

2023

Front. Immunol.

View full text Add to dashboard Cite

Endometriosis is a complex disorder that is characterized by the abnormal growth of endometrial-like tissue outside the uterus. It is associated with chronic inflammation, severe pelvic pain, infertility, and significantly reduced quality of life. Although the exact mechanism of endometriosis remains unknown, inflammation and altered immunity are considered key factors in the immunopathogenesis of the disorder. Disturbances of immune responses result in reduced clearance of regurgitated endometrial cells, which elicits oxidative stress and progression of inflammation. Proinflammatory mediators could affect immune cells’ recruitment, fate, and function. Reciprocally, the activation of immune cells can promote inflammation. Aberrant expression of non-coding RNA (ncRNA) in patient and animal lesions could be suggestive of their role in endometriosis establishment. The engagement of these RNAs in regulating diverse biological processes, including inflammatory responses and activation of inflammasomes, altered immunity, cell proliferation, migration, invasion, and angiogenesis are widespread and far-reaching. Therefore, ncRNAs can be identified as a determining candidate regulating the inflammatory responses and immune system. This review aims in addition to predict the role of ncRNAs in the immunopathogenesis of endometriosis through regulating inflammation and altered immunity based on previous studies, it presents a comprehensive view of inflammation role in the pathogenesis of endometriosis.

show abstract

Non-coding RNAs in immunoregulation and autoimmunity: Technological advances and critical limitations

Cited by 10 publications

References 374 publications

Current situation and trend of non-coding RNA in rheumatoid arthritis: a review and bibliometric analysis

Current situation and trend of non-coding RNA in rheumatoid arthritis: a review and bibliometric analysis

Circular RNA in Multiple Sclerosis: Pathogenicity and Potential Biomarker Development: A Systematic Review

The landscape of non-coding RNAs in the immunopathogenesis of Endometriosis

Contact Info

Product

Resources

About