Non-coding RNAs and lipids mediate the function of extracellular vesicles in cancer cross-talk

Kotani, Ai; Ito, Masatoshi; Kudo, Kai

doi:10.1016/j.semcancer.2021.04.017

Cited by 23 publications

(13 citation statements)

References 189 publications

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“…MiRNAs can be loaded selectively into the exosomes released by cancer cells and directed to their extracellular target compartments, contributing to regulation of different tumor processes, including recruitment of cellular components from the TME. 31 , 32 …”

Section: Introductionmentioning

confidence: 99%

Exosomal microRNAs synergistically trigger stromal fibroblasts in breast cancer

Scognamiglio¹,

Cocca²,

Puoti³

et al. 2022

Molecular Therapy - Nucleic Acids

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Section: Introductionmentioning

confidence: 99%

Exosomal microRNAs synergistically trigger stromal fibroblasts in breast cancer

Scognamiglio¹,

Cocca²,

Puoti³

et al. 2022

Molecular Therapy - Nucleic Acids

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“…Extracellular vesicles (EVs), especially exosomes, have been well-established to deliver microRNAs (miRNAs), proteins, and lipids, and the cargos have been assumed to work cooperatively to modulate tumor microenvironment [ 9 ]. Intriguingly, evidence exists suggesting that exosomes secreted by ectopic endometrial stromal cells could restrict the fibrosis in EMs by delivering a typical miRNA, miR-214 [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Endometrial epithelial cells-derived exosomes deliver microRNA-30c to block the BCL9/Wnt/CD44 signaling and inhibit cell invasion and migration in ovarian endometriosis

et al. 2022

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Endometriosis (EMs) is a benign gynecological disorder showing some tumor-like migratory and invasive phenotypes. This study intended to investigate the role of microRNA-30c (miR-30c) in EMs, which is involved with B-cell lymphoma 9 (BCL9), an activator of the Wnt/β-catenin signaling pathway. EMs specimens were clinically collected for determination of miR-30c and BCL9 expression. Exosomes were isolated from endometrial epithelial cells (EECs), and the uptake of exosomes by ectopic EECs (ecto-EECs) was characterized using fluorescence staining and confocal microscopy. The binding of miR-30c to BCL9 was validated by dual-luciferase reporter assay. Artificial modulation (up- and down-regulation) of the miR-30c/BCL9/Wnt/CD44 regulatory cascade was performed to evaluate its effect on ecto-EEC invasion and migration, as detected by Transwell and wound healing assays. A mouse model of EMs was further established for in vivo substantiation. Reduced miR-30c expression and elevated BCL9 expression was revealed in EMs ectopic tissues and ecto-EECs. Normal EECs-derived exosomes delivered miR-30c to ecto-EECs to suppress their invasive and migratory potentials. Then, miR-30c was observed to inhibit biological behaviors of ecto-EECs by targeting BCL9, and the miR-30c-induced inhibitory effect was reversed by BCL9 overexpression. Further, miR-30c diminished the invasion and migration of ecto-EECs by blocking the BCL9/Wnt/CD44 axis. Moreover, miR-30c-loaded exosomes attenuated the metastasis of ecto-EEC ectopic nodules. miR-30c delivered by EECs-derived exosomes repressed BCL9 expression to block the Wnt/β-catenin signaling pathway, thus attenuating the tumor-like behaviors of ecto-EECs in EMs.

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“…Although these RNAs do not directly translate into proteins ( Gupta et al, 2020 ), driving evidence clarifies that they play an essential role in biological functions ( Chen et al, 2020b ; Jantrapirom et al, 2021 ; Jin et al, 2021 ; Lai et al, 2021 ; Zhang et al, 2021b ). Such is the case of long non-coding RNAs (lncRNAs), which are no less than 200 nucleotides and participate in the initiation and progression of various diseases, especially cancers ( Chen et al, 2020a ; Huang et al, 2021 ; Kotani et al, 2021 ; Luo et al, 2021 ; Teng et al, 2021 ). Abnormal expression of these lncRNAs is involved in a variety of biological processes in tumors via regulation of gene expression that affects tumor size, metastasis, pathological stage, and prognosis in patients ( Yin et al, 2018 ; Shuai et al, 2020 ; Li et al, 2021a ; Zheng et al, 2021 ; Zhong et al, 2021b ).…”

Section: Introductionmentioning

confidence: 99%

Promising Advances in LINC01116 Related to Cancer

Xu¹,

Yu²,

Zhang³

et al. 2021

Front. Cell Dev. Biol.

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Long non-coding RNAs (lncRNAs) are RNAs with a length of no less than 200 nucleotides that are not translated into proteins. Accumulating evidence indicates that lncRNAs are pivotal regulators of biological processes in several diseases, particularly in several malignant tumors. Long intergenic non-protein coding RNA 1116 (LINC01116) is a lncRNA, whose aberrant expression is correlated with a variety of cancers, including lung cancer, gastric cancer, colorectal cancer, glioma, and osteosarcoma. LINC01116 plays a crucial role in facilitating cell proliferation, invasion, migration, and apoptosis. In addition, numerous studies have recently suggested that LINC01116 has emerged as a novel biomarker for prognosis and therapy in malignant tumors. Consequently, we summarize the clinical significance of LINC01116 associated with biological processes in various tumors and provide a hopeful orientation to guide clinical treatment of various cancers in future studies.

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Non-coding RNAs and lipids mediate the function of extracellular vesicles in cancer cross-talk

Cited by 23 publications

References 189 publications

Exosomal microRNAs synergistically trigger stromal fibroblasts in breast cancer

Exosomal microRNAs synergistically trigger stromal fibroblasts in breast cancer

Endometrial epithelial cells-derived exosomes deliver microRNA-30c to block the BCL9/Wnt/CD44 signaling and inhibit cell invasion and migration in ovarian endometriosis

Promising Advances in LINC01116 Related to Cancer

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