Non-coding RNA: insights into the mechanism of methamphetamine neurotoxicity

Gu, Ying-Jian; Chen, Lei; Cheng, Lin; Zhou, Miao; Wang, Yun

doi:10.1007/s11010-021-04160-y

Cited by 4 publications

(3 citation statements)

References 50 publications

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“…In addition, manipulating proteins associated with DNA methylation can also alter drug-related behaviors (see ( Werner et al, 2021 ) and ( Anderson et al, 2018b ) for reviews). Also, other types of cellular regulation, including non-coding RNAs (ncRNA), are beginning to be understood extensively ( Gu et al, 2021 ). For example, long ncRNAs can be regulated by cocaine at least 24 hrs after the last injection ( Bu et al, 2012 ).…”

Section: Limitations and Challenges In The Field Of Epigenetics And S...mentioning

confidence: 99%

Epigenetic Effects of Addictive Drugs in the Nucleus Accumbens

Anderson

Taniguchi

2022

Front. Mol. Neurosci.

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Substance use induces long-lasting behavioral changes and drug craving. Increasing evidence suggests that epigenetic gene regulation contributes to the development and expression of these long-lasting behavioral alterations. Here we systematically review extensive evidence from rodent models of drug-induced changes in epigenetic regulation and epigenetic regulator proteins. We focus on histone acetylation and histone methylation in a brain region important for drug-related behaviors: the nucleus accumbens. We also discuss how experimentally altering these epigenetic regulators via systemically administered compounds or nucleus accumbens-specific manipulations demonstrate the importance of these proteins in the behavioral effects of drugs and suggest potential therapeutic value to treat people with substance use disorder. Finally, we discuss limitations and future directions for the field of epigenetic studies in the behavioral effects of addictive drugs and suggest how to use these insights to develop efficacious treatments.

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Section: Limitations and Challenges In The Field Of Epigenetics And S...mentioning

confidence: 99%

Epigenetic Effects of Addictive Drugs in the Nucleus Accumbens

Anderson

Taniguchi

2022

Front. Mol. Neurosci.

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“…Methamphetamine, a potent and addictive synthetic derivative of amphetamine, is currently one of the most widely abused illegal stimulants worldwide (Henry et al, 2012; Yeo et al, 2007) and is viewed as the greatest global health threat (United Nations Office on Drugs and Crime, 2017). In 2018, approximately 1.9 million people aged 12 years or older (0.7% of the total population) used methamphetamine, including 43,000 adolescents aged 12–17 years (2%), 273,000 adults aged 18–25 years (14%), and 1.6 million adults aged 26 years or older (84%; Gu et al, 2021; Substance Abuse and Mental Health Services Administration, 2013). This percentage was similar to those from 2015 and 2017, but slightly higher than that from 2016 (0.5%; Gu et al, 2021).…”

mentioning

confidence: 99%

“…In 2018, approximately 1.9 million people aged 12 years or older (0.7% of the total population) used methamphetamine, including 43,000 adolescents aged 12–17 years (2%), 273,000 adults aged 18–25 years (14%), and 1.6 million adults aged 26 years or older (84%; Gu et al, 2021; Substance Abuse and Mental Health Services Administration, 2013). This percentage was similar to those from 2015 and 2017, but slightly higher than that from 2016 (0.5%; Gu et al, 2021). Methamphetamine use disorder (MUD) poses a serious threat to personal, social, economic, environmental, and health systems (Huang et al, 2020; Moratalla et al, 2017).…”

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confidence: 99%

Effects of Aerobic Exercise Combined With Attentional Bias Modification in the Care of Male Patients With a Methamphetamine Use Disorder

Liu,

Huang,

Wang

et al. 2024

UJAN

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Objective It remains unclear which individual or combined strategies are most beneficial for methamphetamine use disorders (MUDs). We compared the effects of aerobic exercise, attentional bias modification, and combined intervention on male patients with MUD. Method One hundred male patients with MUD were randomly assigned to combined intervention, aerobic exercise, attentional bias modification, or control groups (25 patients per group). The 8-week intervention protocol included three 60-minute sessions of aerobic exercises per week. Primary outcomes included high- and low-frequency heart rate variability, executive function, and cardiorespiratory fitness measured by customized software, computerized tests, and the Harvard step test, respectively. Secondary outcomes included psychiatric symptoms, drug craving, training acceptability, and persistence. Results Participant characteristics were matched between groups at baseline. Executive function, heart rate variability, cardiorespiratory fitness, drug craving, and most psychiatric symptoms had significant time–group interactions at posttest (p < .05, η2 = .08–.28). Compared with the attentional bias modification and control groups, the combined intervention and aerobic exercise groups improved significantly in executive function, heart rate variability, cardiorespiratory fitness, and most secondary outcomes. In addition, high-frequency heart rate variability and cardiorespiratory fitness in the aerobic exercise group were significantly higher than those in the combined intervention group. Conclusions Combination strategies showed comparable efficacy to aerobic exercise alone in improving executive function, psychiatric symptoms, and drug craving and significantly exceeded other conditions. For heart rate variability and cardiorespiratory fitness, aerobic exercise alone was the most effective. For acceptability and persistence, combination strategies were preferred over single-domain training and health education intervention.

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The Role of Non-coding RNAs in Methamphetamine-Induced Neurotoxicity

Chen

et al. 2023

Cell Mol Neurobiol

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Non-coding RNA: insights into the mechanism of methamphetamine neurotoxicity

Cited by 4 publications

References 50 publications

Epigenetic Effects of Addictive Drugs in the Nucleus Accumbens

Epigenetic Effects of Addictive Drugs in the Nucleus Accumbens

Effects of Aerobic Exercise Combined With Attentional Bias Modification in the Care of Male Patients With a Methamphetamine Use Disorder

The Role of Non-coding RNAs in Methamphetamine-Induced Neurotoxicity

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