The Role of Non-coding RNAs in Methamphetamine-Induced Neurotoxicity

Xu, Luyao; Li, Lingyue; Chen, Qianling; Huang, Yuebing; Chen, Xuebing; Qiao, Dongfang

doi:10.1007/s10571-023-01323-x

Cited by 3 publications

(5 citation statements)

References 185 publications

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“…Nervous system diseases comprise a large portion of NCDs [2,[29][30][31][32][33][34][35][36][37][38][39][40]. Neurodegenerative disorders impact more than fifteen percent of the global population and comprise greater than six hundred disease entities that can result in severe disability and death [10,37,[41][42][43][44][45][46][47].…”

Section: Increased Lifespan Aging Cellular Senescence and Nervous Sys...mentioning

confidence: 99%

Cognitive Impairment in Multiple Sclerosis

Maiese

2023

Bioengineering

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Almost three million individuals suffer from multiple sclerosis (MS) throughout the world, a demyelinating disease in the nervous system with increased prevalence over the last five decades, and is now being recognized as one significant etiology of cognitive loss and dementia. Presently, disease modifying therapies can limit the rate of relapse and potentially reduce brain volume loss in patients with MS, but unfortunately cannot prevent disease progression or the onset of cognitive disability. Innovative strategies are therefore required to address areas of inflammation, immune cell activation, and cell survival that involve novel pathways of programmed cell death, mammalian forkhead transcription factors (FoxOs), the mechanistic target of rapamycin (mTOR), AMP activated protein kinase (AMPK), the silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1), and associated pathways with the apolipoprotein E (APOE-ε4) gene and severe acute respiratory syndrome coronavirus (SARS-CoV-2). These pathways are intertwined at multiple levels and can involve metabolic oversight with cellular metabolism dependent upon nicotinamide adenine dinucleotide (NAD+). Insight into the mechanisms of these pathways can provide new avenues of discovery for the therapeutic treatment of dementia and loss in cognition that occurs during MS.

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Section: Increased Lifespan Aging Cellular Senescence and Nervous Sys...mentioning

confidence: 99%

Cognitive Impairment in Multiple Sclerosis

Maiese

2023

Bioengineering

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“…In particular, microglia are important for removing damaged cells during membrane PS externalization and apoptosis [106,131,145,277,278,298,308,[324][325][326][327]]. Yet, microglia can lead to the generation of oxidative stress through the production of ROS [8,165,167,246,250,[328][329][330][331], which can require modulation by non-coding RNAs [251,[332][333][334][335][336], Wnt signaling [27,28,106,115,276,[337][338][339], and trophic factor pathways with erythropoietin (EPO) [27,[340][341][342][343][344][345][346]. In other scenarios, microglial cells can be helpful for protection during amyotrophic lateral sclerosis [347], remove brain amyloid [348,349], and preserve cholesterol homeostasis with autophagy …”

Section: Cellular Mechanisms Of Oxidative Stress Energy Metabolism An...mentioning

confidence: 99%

“…These small noncoding RNAs also are involved in programmed cell death pathways, such as apoptosis [21,128,305,307,313,[415][416][417][418][419], autophagy [316,334,[420][421][422][423][424][425], ferroptosis [2,426], and pyroptosis [172,427] (Figure 2). MiRNAs consist of 19-25 nucleotides that oversee the expression of genes by silencing or blocking messenger RNAs (mRNAs) that are targeted to translate specific genes into proteins [125,[333][334][335][336]414,[428][429][430][431][432][433][434][435][436][437]. In models of diabetic nephropathy, miRNA activation can block ferroptotic cell injury [426].…”

Section: Non-coding Rnas Micrornas and Circular Rnas In Metabolic Dis...mentioning

confidence: 99%

“…CircRNAs consist of non-coding RNAs of approximately 100 nucleotides [100,142,152,313,316,329,[333][334][335][336]414,419,432,[440][441][442][443][444][445]. First identified as having a circular structure, circRNAs use covalent bonds to maintain a circular nature, contain both cis and trans regulation, oversee the expression of genes through the sponging of miRNAs [335,[446][447][448], and can have value as biomarkers [329,335,429,432,436,449].…”

Section: Non-coding Rnas Micrornas and Circular Rnas In Metabolic Dis...mentioning

confidence: 99%

“…Through pathways that are dependent upon TREM2, new therapies using microglia are being considered to improve cognition, reduce memory loss, block inflammation, and be important tools for identifying metabolic disease progression. The therapeutic pathways that oversee microglia function are intimately tied to non-coding RNAs that oversee inflammatory pathways [251,[332][333][334][335][336], Wnt signaling, and growth factors, such as EPO. Growth factors, such as EPO, are also being seen as necessary to control AMPK and non-coding RNA pathways.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Cornerstone Cellular Pathways for Metabolic Disorders and Diabetes Mellitus: Non-Coding RNAs, Wnt Signaling, and AMPK

Maiese

2023

Cells

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Metabolic disorders and diabetes (DM) impact more than five hundred million individuals throughout the world and are insidious in onset, chronic in nature, and yield significant disability and death. Current therapies that address nutritional status, weight management, and pharmacological options may delay disability but cannot alter disease course or functional organ loss, such as dementia and degeneration of systemic bodily functions. Underlying these challenges are the onset of aging disorders associated with increased lifespan, telomere dysfunction, and oxidative stress generation that lead to multi-system dysfunction. These significant hurdles point to the urgent need to address underlying disease mechanisms with innovative applications. New treatment strategies involve non-coding RNA pathways with microRNAs (miRNAs) and circular ribonucleic acids (circRNAs), Wnt signaling, and Wnt1 inducible signaling pathway protein 1 (WISP1) that are dependent upon programmed cell death pathways, cellular metabolic pathways with AMP-activated protein kinase (AMPK) and nicotinamide, and growth factor applications. Non-coding RNAs, Wnt signaling, and AMPK are cornerstone mechanisms for overseeing complex metabolic pathways that offer innovative treatment avenues for metabolic disease and DM but will necessitate continued appreciation of the ability of each of these cellular mechanisms to independently and in unison influence clinical outcome.

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Abnormal static and dynamic amplitude of low-frequency fluctuations in multiple brain regions of methamphetamine abstainers

Liang,

Li,

Yuan

et al. 2023

MBE

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<abstract> <p>Methamphetamine (meth) addiction is a significant social and public health problem worldwide. The relapse rate of meth abstainers is significantly high, but the underlying physiological mechanisms are unclear. Therefore, in this study, we performed resting-state functional magnetic resonance imaging (rs-fMRI) analysis to detect differences in the spontaneous neural activity between the meth abstainers and the healthy controls, and identify the physiological mechanisms underlying the high relapse rate among the meth abstainers. The fluctuations and time variations in the blood oxygenation level-dependent (BOLD) signal of the local brain activity was analyzed from the pre-processed rs-fMRI data of 11 meth abstainers and 11 healthy controls and estimated the amplitude of low-frequency fluctuations (ALFF) and the dynamic ALFF (dALFF). In comparison with the healthy controls, meth abstainers showed higher ALFF in the anterior central gyrus, posterior central gyrus, trigonal-inferior frontal gyrus, middle temporal gyrus, dorsolateral superior frontal gyrus, and the insula, and reduced ALFF in the paracentral lobule and middle occipital gyrus. Furthermore, the meth abstainers showed significantly reduced dALFF in the supplementary motor area, orbital inferior frontal gyrus, middle frontal gyrus, medial superior frontal gyrus, middle occipital gyrus, insula, middle temporal gyrus, anterior central gyrus, and the cerebellum compared to the healthy controls ($ P < 0.05 $). These data showed abnormal spontaneous neural activity in several brain regions related to the cognitive, executive, and other social functions in the meth abstainers and potentially represent the underlying physiological mechanisms that are responsible for the high relapse rate. In conclusion, a combination of ALFF and dALFF analytical methods can be used to estimate abnormal spontaneous brain activity in the meth abstainers and make a more reasonable explanation for the high relapse rate of meth abstainers.</p> </abstract>

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The Role of Non-coding RNAs in Methamphetamine-Induced Neurotoxicity

Cited by 3 publications

References 185 publications

Cognitive Impairment in Multiple Sclerosis

Cognitive Impairment in Multiple Sclerosis

Cornerstone Cellular Pathways for Metabolic Disorders and Diabetes Mellitus: Non-Coding RNAs, Wnt Signaling, and AMPK

Abnormal static and dynamic amplitude of low-frequency fluctuations in multiple brain regions of methamphetamine abstainers

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