Non-coding AUG circRNAs constitute an abundant and conserved subclass of circles

Stagsted, Lotte Victoria Winther; Nielsen, Katrine Mandrup; Daugaard, Iben

doi:10.1101/328104

Cited by 3 publications

(3 citation statements)

References 54 publications

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“…LKPT evidenced in the present work also possesses a lysine amino acid residue in N-terminal position as it was also found in the minimal sequence from α-actinin-2 (KPYIL) able to stimulate the GLP-1 secretion in murine GLUTag cells. However, the K residue position in the sequence does not seem crucial for the bioactivity as ASDKPYIL is also active [51]. The RVASMASEKM peptide, recently identified from egg white protein digest as GLP-1 secretagogue, also possesses a K residue but in C-terminal position [48].…”

Section: Discussionmentioning

confidence: 99%

New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation after Canine Gastrointestinal Simulated Digestion

et al. 2020

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Like their owners, dogs and cats are more and more affected by overweight and obesity-related problems and interest in functional pet foods is growing sharply. Through numerous studies, fish protein hydrolysates have proved their worth to prevent and manage obesity-related comorbidities like diabetes. In this work, a human in vitro static simulated gastrointestinal digestion model was adapted to the dog which allowed us to demonstrate the promising effects of a tilapia byproduct hydrolysate on the regulation of food intake and glucose metabolism. Promising effects on intestinal hormones secretion and dipeptidyl peptidase IV (DPP-IV) inhibitory activity were evidenced. We identify new bioactive peptides able to stimulate cholecystokinin (CCK) and glucagon-like peptide 1 (GLP-1) secretions, and to inhibit the DPP-IV activity after a transport study through a Caco-2 cell monolayer.

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Section: Discussionmentioning

confidence: 99%

New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation after Canine Gastrointestinal Simulated Digestion

et al. 2020

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“…Depending on the source, the understudied proteins could come from genomic mutations, alternative splicing, and noncoding RNA 8 . Translatable circRNAs play a role in lifting the veil of the 'ghost proteome' 9 . CircRNAs have been proposed to function in the assembly of complexes by competing with microRNAs (miRNAs) or RNA-binding proteins (RBPs) but have lost sight of their coding potential [10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

CICADA: a circRNA effort to Ghost proteome

Sun,

Fan,

Zhou

et al. 2023

Preprint

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Coding genes constitute only a small portion of the human genome. Recently, circular RNAs (circRNAs), commonly thought to be noncoding, have been demonstrated to be translated into novel proteins, which might mediate diverse biological processes. However, it remains challenging to identify translatable circRNAs and circRNA-coded proteins. Here, we introduce CICADA, an algorithm capable of evaluating the coding ability of circRNAs and inferring circRNA-coded products. We find that CICADA's performance is highly efficient and cost-effective compared to existing algorithms. Moreover, we used CICADA to successfully identify functional translatable circRNAs in esophageal squamous cell carcinoma and construct circRNA translation profiles across various cancers. CICADA provides an efficient tool to explore the hidden proteome encoded by translatable circRNAs.

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“…It has been shown that particular circRNAs function as direct or indirect regulators of host gene expression at the transcriptional level [ 21 , 22 ], as sponges of microRNAs (miRNAs) [ 23 , 24 ], as protein scaffolds [ 25 ], or as specific or global regulators of protein translation [ 26 , 27 ]. Recent studies have reported that some circRNAs under certain circumstances can serve as templates for translation [ 28 , 29 , 30 , 31 ], yet the vast majority of circRNAs are considered to be non-coding [ 32 ]. See Figure 3 .…”

Section: Introductionmentioning

confidence: 99%

Long Non-Coding RNAs Guide the Fine-Tuning of Gene Regulation in B-Cell Development and Malignancy

Dahl

Kristensen

Grønbæk

2018

IJMS

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With the introduction of next generation sequencing methods, such as RNA sequencing, it has become apparent that alterations in the non-coding regions of our genome are important in the development of cancer. Particularly interesting is the class of long non-coding RNAs (lncRNAs), including the recently described subclass of circular RNAs (circRNAs), which display tissue- and cell-type specific expression patterns and exert diverse regulatory functions in the cells. B-cells undergo complex and tightly regulated processes in order to develop from antigen naïve cells residing in the bone marrow to the highly diverse and competent effector cells circulating in peripheral blood. These processes include V(D)J recombination, rapid proliferation, somatic hypermutation and clonal selection, posing a risk of malignant transformation at each step. The aim of this review is to provide insight into how lncRNAs including circRNAs, participate in normal B-cell differentiation, and how deregulation of these molecules is involved in the development of B-cell malignancies. We describe the prognostic value and functional significance of specific deregulated lncRNAs in diseases such as acute lymphoblastic leukemia, chronic lymphocytic leukemia, mantle cell lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, Burkitt lymphoma and multiple myeloma, and we provide an overview of the current knowledge on the role of circRNAs in these diseases.

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Non-coding AUG circRNAs constitute an abundant and conserved subclass of circles

Abstract: 16Circular RNAs (circRNAs) are a subset of non-coding RNAs (ncRNAs) previously considered as 17

Cited by 3 publications

References 54 publications

New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation after Canine Gastrointestinal Simulated Digestion

New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation after Canine Gastrointestinal Simulated Digestion

CICADA: a circRNA effort to Ghost proteome

Long Non-Coding RNAs Guide the Fine-Tuning of Gene Regulation in B-Cell Development and Malignancy

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