Non-capsulate Haemophilus influenzae: a neglected pathogen in adults.

Ispahani, P.; Youngs, E R

doi:10.1136/bmj.290.6485.1870-a

Cited by 3 publications

(1 citation statement)

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“…The median ages in the cystic fibrosis and asthma groups were 7-5 and 7*1 years respectively. The median Shwachman score " in the group with cystic fibrosis was 82 (range 43-94), and the median Chrispin-Norman x ray score'2 was 6 (range [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Five patients with cystic fibrosis were chronically infected with P aeruginosa.…”

Section: Resultsmentioning

confidence: 99%

Haemophilus infection in cystic fibrosis.

Rayner

Hiller²,

Ispahani³

et al. 1990

Archives of Disease in Childhood

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Twenty seven patients with cystic fibrosis under the age of 12 years and 27 matched patients with asthma were followed up in a prospective study for one year. The isolation rate of non-capsulated strains ofHaemophilus influenzae from cough swabs and sputum specimens taken at routine clinic visits every two months was significantly greater in cystic fibrosis than in asthma. Haemophilus parainfluenzae was equally common in both groups. During exacerbations the isolation rate of H influenzae in cystic fibrosis was significantly greater than at other times, whereas in asthma there was no significant difference.The distribution of biotypes ofH influenzae and H parainfluenzae was similar in the two groups. In cystic fibrosis, biotype I was associated with exacerbations. Biotype V was more common than in previous studies, but was not associated with exacerbations.

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Section: Resultsmentioning

confidence: 99%

Haemophilus infection in cystic fibrosis.

Rayner

Hiller²,

Ispahani³

et al. 1990

Archives of Disease in Childhood

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Infektionen der tiefen Atemwege in der Allgemeinpraxis

Cazzola¹

1987

Infection

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Haemophilus influenzae and Streptococcus pneumoniae are found in 87% of all cases of exacerbated chronic obstructive bronchopulmonary disease. Complications of viral respiratory tract disease are most frequently caused by H. influenzae. Not only encapsulated forms of H. influenzae, but also non-encapsulated strains may be responsible for the onset of pneumonia and acute exacerbations of chronic bronchitis in adults. The most common symptoms of infections with H. influenzae are cough, dyspnoea, increase in purulent sputum and wheezing. A quantitative sputum culture is recommended for diagnosing chronic obstructive bronchopulmonary disease. Acute exacerbations of chronic bronchitis are always treated with antibiotics effective against H. influenzae and pneumococci. As a rule, empirical treatment should suffice in general practice. In the comparison between ampicillin, co-trimoxazole and cefaclor included in the study protocol appended to this report, the latter produced the most favourable results both in the empirical and specific forms of treatment. We would recommend cefaclor as the antibiotic of choice for this disease.

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