Haemophilus infection in cystic fibrosis.

Rayner, R J; Hiller, E; Ispahani, P.; Baker, Mary Grace

doi:10.1136/adc.65.3.255

Cited by 37 publications

(34 citation statements)

References 15 publications

(17 reference statements)

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“…We found that H. influenzae was associated with lower FVC. While H. influenzae has been found to be associated with pulmonary exacerbations [32], and with higher leukocyte and neutrophil counts in bronchoalveolar lavage fluid from CF infants [5]; to our knowledge, the association of H. influenzae with lung function has previously only been evaluated in one study using FEV1 among children aged .6 yrs [33] and a significant effect was not detected in that study. However, the clinical significance of an effect of H. influenzae on vital capacity without an effect on airway obstruction (forced expiratory flows) is unclear.…”

mentioning

confidence: 60%

Lung function from infancy to preschool in a cohort of children with cystic fibrosis

Brumback

Davis²,

Kerby

et al. 2012

European Respiratory Journal

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This study aimed to describe lung function in a cohort of children with cystic fibrosis (CF) who underwent infant pulmonary function tests (IPFTs) and preschool spirometry.Children performed up to four IPFTs (raised volume rapid thoracic compression technique) over 1 yr and five preschool spirometry tests over up to 2 yrs during participation in prospective, multicentre studies of infant and preschool lung function. All lung function data were reviewed centrally for measurement acceptability.45 children had 252 acceptable measurements (137 IPFTs and 115 preschool spirometries) at ages 0.3-6.5 yrs. The median number of measurements per participant was 6 (range 3-9). Recent Pseudomonas aeruginosa infection was associated with 5.1% (95% CI 0.01-9.9%) lower forced expiratory volume in 0.5 s (FEV0.5) and 16.4% (95% CI 7.0-24.9%) lower forced expiratory flow at 25-25% of forced vital capacity (FEF25-75%), after adjustment for length, test type and centre. Recent cough was associated with 5.7% (95% CI 1.1-10.1%) lower FEV0.5 and 10.1% (95% CI 0.6-18.7%) lower FEF25-75%. Even after accounting for infection status, cough, sex, length, test type and centre, there was significant inter-individual variability in lung function (p,0.01 for each of FEV0.5, FEF25-75% and forced vital capacity).Recent P. aeruginosa infection and cough are associated with lower lung function in children with CF. Significant inter-individual variability in lung function remains to be explained.

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confidence: 60%

Lung function from infancy to preschool in a cohort of children with cystic fibrosis

Brumback

Davis²,

Kerby

et al. 2012

European Respiratory Journal

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“…In addition, BRUMBACK et al [42] found that recent H. influenzae infection was associated with lower forced vital capacity in preschool children with CF. Infection with H. influenzae has also been associated with pulmonary inflammation [14,31] and pulmonary exacerbations [43] in children with CF. These data indicate that H. influenzae is highly pathogenic in young children with CF, and should be targeted for eradication and treatment to improve lung function outcomes.…”

Section: Discussionmentioning

confidence: 99%

Impact of lung disease on respiratory impedance in young children with cystic fibrosis

et al. 2015

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This study aimed to evaluate the ability of the forced oscillation technique (FOT) to detect underlying lung disease in preschool children with cystic fibrosis (CF) diagnosed following newborn screening.184 children (aged 3-6 years) with CF underwent lung function testing on 422 occasions using the FOT to assess respiratory resistance and reactance at the time of their annual bronchoalveolar lavage collection and chest computed tomography scan. We examined associations between FOT outcomes and the presence and progression of respiratory inflammation, infection and structural lung disease.Children with CF who had pronounced respiratory disease, including free neutrophil elastase activity, infection with pro-inflammatory pathogens and structural lung abnormalities had similar FOT outcomes to those children without detectable lung disease. In addition, the progression of lung disease over 1 year was not associated with worsening FOT outcomes.We conclude that the forced oscillation technique is relatively insensitive to detect underlying lung disease in preschool children with CF. However, FOT may still be of value in improving our understanding of the physiological changes associated with early CF lung disease. @ERSpublications Forced oscillation technique is insensitive in detecting lung disease in preschool children with cystic fibrosis http://ow.ly/R9rSU

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“…Approximately 82% of children with P. aeruginosa had previous isolates of S. aureus or H. influenzae (14). During exacerbations of CF lung disease in children, the isolation rate of H. influenzae was significantly greater than at other times (38).…”

Section: Nthi In Early Cf Lung Diseasementioning

confidence: 99%

“…For reasons that are not fully understood, NTHi causes persistent infections despite appropriate antibiotic therapy in diseases with abnormalities of mucociliary clearance, such as COPD (35,41) and CF (11,(38)(39)(40). Because H. influenzae forms biofilms on airway epithelia that display decreased susceptibility to antimicrobials, this may help to explain why such infections persist despite antibiotic treatment in OM, COPD, and CF (40,42,43).…”

Section: Nthi Biofilms: a Possible Link To Early Cf Lung Diseasementioning

confidence: 99%