Non-antibiotic prevention and treatment against Acinetobacter baumannii infection: Are vaccines and adjuvants effective strategies?

Hu, Yue; Zhang, Xianqin; Deng, Shanshan; Yue, Changwu; Xu, Jin; Lyu, Yuhong

doi:10.3389/fmicb.2023.1049917

Cited by 5 publications

(5 citation statements)

References 94 publications

(109 reference statements)

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“…Moreover, besides antibiotics, nonantibiotic treatment strategies are being investigated for the treatment of bacterial resistance. Recently, new research on A. baumannii vaccines, specifically whole-cell vaccines, including inactivated and live attenuated bacterial ghost and DNA ones, has been reported [ 141 ]. Infections caused by extensively drug-resistant A. baumannii (XDR-Ab) and plasmid/chromosomal-mediated (Col-R- Ab COL R - Ab ) are the main challenge and need a well-planned control program and proper treatment [ 142 , 143 ].…”

Section: Therapies For Antibiotic-resistant Bacteriamentioning

confidence: 99%

Antibiotic-Resistant ESKAPE Pathogens and COVID-19: The Pandemic beyond the Pandemic

Catalano,

Iacopetta,

Ceramella

et al. 2023

Viruses

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Antibacterial resistance is a renewed public health plague in modern times, and the COVID-19 pandemic has rekindled this problem. Changes in antibiotic prescribing behavior, misinformation, financial hardship, environmental impact, and governance gaps have generally enhanced the misuse and improper access to antibiotics during the COVID-19 pandemic. These determinants, intersected with antibacterial resistance in the current pandemic, may amplify the potential for a future antibacterial resistance pandemic. The occurrence of infections with multidrug-resistant (MDR), extensively drug-resistant (XDR), difficult-to-treat drug-resistant (DTR), carbapenem-resistant (CR), and pan-drug-resistant (PDR) bacteria is still increasing. The aim of this review is to highlight the state of the art of antibacterial resistance worldwide, focusing on the most important pathogens, namely Enterobacterales, Acinetobacter baumannii, and Klebsiella pneumoniae, and their resistance to the most common antibiotics.

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Section: Therapies For Antibiotic-resistant Bacteriamentioning

confidence: 99%

Antibiotic-Resistant ESKAPE Pathogens and COVID-19: The Pandemic beyond the Pandemic

Catalano,

Iacopetta,

Ceramella

et al. 2023

Viruses

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“…This results in resistance to many antibiotics, such as carbapenems, tigecycline, etc. [ 101 ]. The current severe situation in A. baumannii infections is that no effective drugs are available [ 102 ].…”

Section: The Role Of Omvs In the Pathogenesis Of A Baumanniimentioning

confidence: 99%

“…Pumps expel antibiotics out of the cell, which decreases drug accumulation and increases the minimum inhibitory concentration (MIC) required. Efflux pumps could also be implicated in the early stages of infection, causing complications such as adhesion to host cells and colonization [ 101 ].…”

Section: The Role Of Omvs In the Pathogenesis Of A Baumanniimentioning

confidence: 99%

Outer Membrane Vesicles from Acinetobacter baumannii: Biogenesis, Functions, and Vaccine Application

Weng,

Yang,

Shi

et al. 2023

Vaccines

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This review focuses on Acinetobacter baumannii, a Gram-negative bacterium that causes various infections and whose multidrug resistance has become a significant challenge in clinical practices. There are multiple bacterial mechanisms in A. baumannii that participate in bacterial colonization and immune responses. It is believed that outer membrane vesicles (OMVs) budding from the bacteria play a significant role in mediating bacterial survival and the subsequent attack against the host. Most OMVs originate from the bacterial membranes and molecules are enveloped in them. Elements similar to the pathogen endow OMVs with robust virulence, which provides a new direction for exploring the pathogenicity of A. baumannii and its therapeutic pathways. Although extensive research has been carried out on the feasibility of OMV-based vaccines against pathogens, no study has yet summarized the bioactive elements, biological activity, and vaccine applicability of A. baumannii OMVs. This review summarizes the components, biogenesis, and function of OMVs that contribute to their potential as vaccine candidates and the preparation methods and future directions for their development.

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“…Since antibiotic-resistant A. baumannii is one of the most common pathogens that cause infections, WHO published the list (ESKAPE) of pathogens that urgently need new antimicrobial developments in 2017 and designated this pathogen as a "priority status" [4]. As mentioned above, polymyxins and tigecycline are the last treatment strategy for A. baumanii, one of the ESKAPE species, but there are resistant strains that overcome this strategy, so new treatment and control measures should be taken urgently [5].…”

Section: Introductionmentioning

confidence: 99%

Increased sensitivity to the aromatic antibiotic novobiocin in Acinetobacter baumannii by vanillic acid

Sariyer,

Sariyer

2024

Preprint

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This paper focuses on in vitro analysis of the ability of vanillic acid to potentiate representative antibiotics, which are substrates of pumps responsible for antibiotic resistance in Acinetobacter baumannii. To investigate whether vanillic acid can potentiate antibiotics in cells overexpressing the AdeABC, AdeFGH, and AdeIJK efflux pumps, a minimum potentiation concentration determination (MPC4) experiment was performed. Vanillic acid potentiates novobiocin (8-fold) in Acinetobacter baumannii overexpressing AdeIJK. RNA-seq analysis was used to examine the gene-level effects of vanillic acid in AdeIJK-overexpressing cells treated with a sub-MIC concentration of novobiocin. AdeIJK overexpressing cells were cultivated at a sub-MIC concentration of novobiocin alone (1.5625 µg/ml) and at a sub-MIC concentration of novobiocin (1.5625 µg/ml) and vanillic acid (50 µg/ml) together in order to ascertain the effect of vanillic acid at the transcriptional level. DEG results revealed the upregulation of genes involved in the degradation and transport of aromatic compounds, along with alcohol metabolism. From the results of the present study, the upregulation of genes related to the degradation of aromatic compounds is regulated by vanillic acid, which is not surprising, and this may also make it possible to increase novobiocin sensitivity, aligning with existing literature. However, it is crucial to validate these findings through experimental studies in the future. In conclusion, our study highlights the potential regulatory role of vanillic acid, warranting further investigation.

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Non-antibiotic prevention and treatment against Acinetobacter baumannii infection: Are vaccines and adjuvants effective strategies?

Cited by 5 publications

References 94 publications

Antibiotic-Resistant ESKAPE Pathogens and COVID-19: The Pandemic beyond the Pandemic

Antibiotic-Resistant ESKAPE Pathogens and COVID-19: The Pandemic beyond the Pandemic

Outer Membrane Vesicles from Acinetobacter baumannii: Biogenesis, Functions, and Vaccine Application

Increased sensitivity to the aromatic antibiotic novobiocin in Acinetobacter baumannii by vanillic acid

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