Non-alcoholic fatty liver disease and 30-day all-cause mortality in adult patients with community-acquired pneumonia

Nseir, William; Mograbi, Julnar; Amara, Amir; Elheja, O H Abu; Mahamid, Mahmud

doi:10.1093/qjmed/hcy227

Cited by 44 publications

(47 citation statements)

References 26 publications

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“…Many studies have assessed means of predicting disease severity and outcomes to enable adequate allocation of healthcare resources and optimal treatment. Several efforts have been made to identify potential predictors of prognosis in CAP [3,5,6,[9][10][11][12][13][14][15]. Currently, pneumonia severity scales such as CURB-65 (confusion, urea, respiration, blood pressure, and age > 65 years) and the pneumo-nia severity index (PSI) are widely used to predict prognosis.…”

Section: Introductionmentioning

confidence: 99%

Usefulness of mean platelet volume to platelet count ratio for predicting the risk of mortality in community-acquired pneumonia

Cho

Lee

et al. 2020

aoms

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Introduction: The association between mean platelet volume (MPV) to platelet count (PC) ratio and prognosis has been demonstrated in some diseases but not in community-acquired pneumonia (CAP). In this study, we evaluated the ability of MPV to PC ratio (MPR) to predict short-term mortality in CAP patients. Material and methods: We retrospectively analysed data archived over 10 years and stratified MPR values into quartiles. Relations between MPR (femtoliters/number of thousand platelets per microlitre) quartiles and 60-day mortality were examined. Logistic regression was performed to adjust for confounders, and the Kaplan-Meier method was used for survival analysis. Results: After adjusting for confounding factors, the odds ratios of 60-day mortality for CAP were 2.66 (95% CI: 2.04-3.46) for the fourth MPR quartile (range ≥ 5.19; p < 0.001) versus the first MPR quartile (range ≤ 2.45). Kaplan-Meier curves indicated that a higher MPR was associated with a higher risk of mortality among CAP patients, and this was confirmed by the log-rank test (p < 0.001). Conclusions: Mean platelet volume to PC ratio was found to be positively correlated with short-term mortality. Our data indicate that MPR might be a significant predictive marker of the mortality in CAP. Further prospective studies are required to establish the exact role of MPR in CAP and other diseases.

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Section: Introductionmentioning

confidence: 99%

Usefulness of mean platelet volume to platelet count ratio for predicting the risk of mortality in community-acquired pneumonia

Cho

Lee

et al. 2020

aoms

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“…[2] Patients with metabolic associated fatty liver disease (MAFLD), [3] formerly known as non-alcoholic fatty liver disease, are often obese and have additional metabolic risk factors which may translate to a greater risk from respiratory diseases. [4][5][6][7] It is currently not known whether MALFD patients are also more likely to have greater COVID-19 severity of illness. This study investigated the association between MAFLD and COVID-19 severity.…”

mentioning

confidence: 99%

Letter to the Editor: Obesity as a risk factor for greater severity of COVID-19 in patients with metabolic associated fatty liver disease

et al. 2020

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“…NAFLD has been well established as a predictor of increased all-cause mortality in a recently conducted comprehensive meta-analysis [30]. Similarly, Nseir et al demonstrated an increase in the all-cause 30-day mortality among NAFLD subjects who presented with Communityacquired pneumonia [21].…”

Section: Discussionmentioning

confidence: 96%

“…Several Recent studies have shown the association between NAFLD and bacterial infections [20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Nonalcoholic fatty liver disease as a risk factor for severity of acute cholangitis

Mahmud

Fteiha

Nubani

et al. 2020

Preprint

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Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver disorders worldwide. Acute cholangitis (AC) is a serious and life-threatening illness. We aimed to determine whether NAFLD is a risk factor for severity of AC.Methods: We retrospectively studied hospitalized patients with diagnosis of AC over the span of 5 years. Subjects were divided into a NAFLD group and Non NAFLD group. We compared between the two groups in terms of demographic characteristics, comorbidities, laboratory data, and severity of AC (including Charlson Comorbidity index and Tokyo Consensus meeting criteria). Results: 298 of 419 patients who had AC and were hospitalized met the inclusion criteria and were included in the study. Of them, 73/298 (24.5%) were included in NAFLD group. NAFLD group patients were younger, diabetic and more obese than non NAFLD group. Subjects in the NAFLD presented with higher serum C-reactive protein and higher liver enzymes (p<0.05, for each parameter) and suffered more events of organ dysfunction(p<0.001) and bacteremia (p<0.005). Regarding the severity of AC according to Tokyo classification, among the NAFLD group more subjects presented with Grade II (39.7 Vs 33.3%, p <0.001) and Grade III (23.3 vs 18.3, p<0.001) cholangitis, as opposed more Grade I cholangitis among the non-NAFLD group (48.4 vs 37%, p<0.001). Multivariate logistic regression analysis showed that NAFLD is independently associated with severe AC, grade III (OR 3.25, 95% CI 1.65-6.45, p=0.038). Conclusions: NAFLD is as an independent risk factor for severity of AC.

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Non-alcoholic fatty liver disease and 30-day all-cause mortality in adult patients with community-acquired pneumonia

Cited by 44 publications

References 26 publications

Usefulness of mean platelet volume to platelet count ratio for predicting the risk of mortality in community-acquired pneumonia

Usefulness of mean platelet volume to platelet count ratio for predicting the risk of mortality in community-acquired pneumonia

Letter to the Editor: Obesity as a risk factor for greater severity of COVID-19 in patients with metabolic associated fatty liver disease

Nonalcoholic fatty liver disease as a risk factor for severity of acute cholangitis

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