Usefulness of mean platelet volume to platelet count ratio for predicting the risk of mortality in community-acquired pneumonia

Abstract

Introduction: The association between mean platelet volume (MPV) to platelet count (PC) ratio and prognosis has been demonstrated in some diseases but not in community-acquired pneumonia (CAP). In this study, we evaluated the ability of MPV to PC ratio (MPR) to predict short-term mortality in CAP patients. Material and methods: We retrospectively analysed data archived over 10 years and stratified MPR values into quartiles. Relations between MPR (femtoliters/number of thousand platelets per microlitre) quartiles and 60-day mortality were examined. Logistic regression was performed to adjust for confounders, and the Kaplan-Meier method was used for survival analysis. Results: After adjusting for confounding factors, the odds ratios of 60-day mortality for CAP were 2.66 (95% CI: 2.04-3.46) for the fourth MPR quartile (range ≥ 5.19; p < 0.001) versus the first MPR quartile (range ≤ 2.45). Kaplan-Meier curves indicated that a higher MPR was associated with a higher risk of mortality among CAP patients, and this was confirmed by the log-rank test (p < 0.001). Conclusions: Mean platelet volume to PC ratio was found to be positively correlated with short-term mortality. Our data indicate that MPR might be a significant predictive marker of the mortality in CAP. Further prospective studies are required to establish the exact role of MPR in CAP and other diseases.

Prognostic Significance of Platelet and Mean Platelet Volume Kinetics for Ventilator-Associated Pneumonia

“…Last, Cho et al examined the MPV/PC ratio in terms of mortality risk in CAP patients. The MPV/PC ratio presented a higher prognostic value than MPV or PC alone, and it was also equivalent to procalcitonin (30). However, the results of this study showed a similar prognostic value between the MPV/PC ratio and MPV in VAP patients and showed that MPV/PC is a weaker predictor of mortality than MPV.…”

“…Platelet Indices for Ventilator-Associated Pneumonia JARSS 2023;31(1):[28][29][30][31][32][33][34][35][36] …”

A risk scoring system integrating postoperative factors for predicting early mortality after major non‐cardiac surgery

“…We included a novel CBC‐based index, NMLPR, in the final clinical scoring system, which strongly correlated with postoperative mortality risk. NMLPR is a composite index of NLR × MPR, both of which are known predictors of postoperative and other disease‐related mortalities 12,14–16,32–34 . The use of composite indices offers two main advantages: (1) they compress information and (2) increase the diagnostic and prognostic specificity of individual biomarkers.…”

“…NMLPR is a composite index of NLR × MPR, both of which are known predictors of postoperative and other disease‐related mortalities. 12 , 14 , 15 , 16 , 32 , 33 , 34 The use of composite indices offers two main advantages: (1) they compress information and (2) increase the diagnostic and prognostic specificity of individual biomarkers. With systemic inflammation, the lymphocyte count decreases and the neutrophil count increases.…”

“…NMLPR is a composite index of NLR × MPR, both of which are known predictors of postoperative and other disease-related mortalities. 12,[14][15][16][32][33][34] The use of composite indices offers two main advantages:…”