Non-alcoholic fatty liver disease among patients with sleep disorders: a Nationwide study of Taiwan

Wei, Yu-Ting; Lee, Peng-Yi; Lin, Chii Jeng; Chen, Hsuan Ju; Lin, Chih‐Hsueh; Wu, Jin Shang; Chang, Yin Fan; Wu, Chen Long; Guo, How‐Ran

doi:10.1186/s12876-020-1178-7

Cited by 13 publications

(12 citation statements)

References 52 publications

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“…Considering the potential delay and miscoded diagnosis of narcolepsy from inpatient settings 35 . we used a series of ICD-9-CM codes (307.4x, 347.xx and 780.5x, Supplementary Table 1) to investigate a broader range of relevant sleeping disorders according to ACCESS -a project funded by the EMA for the safety monitoring of COVID-19 vaccines 36 .…”

Section: Discussionmentioning

confidence: 99%

“…The initial motivation for including narcolepsy in the list of interested AIDs was due to the widely reported increased risk of narcolepsy among Pandemrix (AS03 adjuvanted pandemic A/H1N1 influenza vaccine) recipients in European countries and Canada during the 2009 H1N1 pandemic 27-32 , which could contribute to vaccine hesitancy against COVID-19 33,34 . Considering the potential delay and miscoded diagnosis of narcolepsy from inpatient settings 35 . we used a series of ICD-9-CM codes (307.4x, 347.xx and 780.5x, Supplementary Table 1) to investigate a broader range of relevant sleeping disorders according to ACCESS - a project funded by the EMA for the safety monitoring of COVID-19 vaccines 36 .…”

Section: Discussionmentioning

confidence: 99%

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Autoimmune conditions following mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccination: a descriptive cohort study among 1.1 million vaccinated people in Hong Kong

Gao

Tong

et al. 2021

Preprint

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Background Concerns regarding the autoimmune safety of COVID-19 vaccines may negatively impact vaccine uptake. We aimed to describe the incidence of autoimmune conditions following BNT162b2 and CoronaVac vaccination and compare these with age-standardized incidence rates in non-vaccinated individuals. Methods This is a descriptive cohort study conducted in public healthcare service settings. Territory-wide longitudinal electronic medical records of Hong Kong Hospital Authority users (≥16 years) were linked with COVID-19 vaccination records between February 23, 2021 and June 30, 2021. We classified participants into first/second dose BNT162b2 groups, first/second dose CoronaVac groups and non-vaccinated individuals for incidence comparison. The study outcomes include hospitalized autoimmune diseases (16 types of immune-mediated diseases across six body systems) within 28 days after first and second dose of vaccination. Age-standardized incidence rate ratios (IRRs) with exact 95% confidence intervals (CIs) were estimated using Poisson distribution. Results This study included around 3.9 million Hong Kong residents, of which 1,122,793 received at least one dose of vaccine (BNT162b2: 579,998; CoronaVac: 542,795), and 721,588 completed two doses (BNT162b2: 388,881; CoronaVac: 332,707). Within 28 days following vaccination, cumulative incidences for all autoimmune conditions were below 9 per 100,000 persons, for both vaccines and both doses. None of the age-standardized incidence rates were significantly higher than the non-vaccinated individuals, except for an observed increased incidence of hypersomnia following the first dose of BNT162b2 (standardized IRR: 1.47; 95% CI: 1.10–1.94). Conclusions Autoimmune conditions requiring hospital care are rare following mRNA and inactivated virus COVID-19 vaccination with similar incidence to non-vaccinated individuals. The association between first dose BNT162b2 vaccination and immune-related sleeping disorders requires further research. Population-based robust safety surveillance is essential to detect rare and unexpected vaccine safety events. Funding: Research Grant from the Food and Health Bureau, the Government of the Hong Kong Special Administrative Region (Ref. No. COVID19F01).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Autoimmune conditions following mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccination: a descriptive cohort study among 1.1 million vaccinated people in Hong Kong

Gao

Tong

et al. 2021

Preprint

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“…Perhaps more males consumed alcohol which may lead to liver damage. [ 21 ] A study by Babak Bagheri et al showed that male sex was a risk factor for elevated serum creatinine levels. [ 22 ] Fourthly, the proportions of smokers, individuals exposed to passive smoke, and individuals who consumed alcohol were higher among males than females (27.70% vs 0.24%, 10.94% vs 3.58%, and 15.62% vs 1.07%), and these are social determinants of chronic disease.…”

Section: Discussionmentioning

confidence: 99%

The risk factors of adverse pregnancy outcome for pre-pregnancy couples in Hunan, China

Xie¹,

Xiang

Wang³

et al. 2020

Medicine

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To identify the prevalence of chronic disease and behavior risk factors of adverse pregnancy outcome for pre-pregnancy couples in Hunan province, China. A retrospective study including cross-sectional datas from the Free Pre-pregnancy Health Check (FPHC) surveillance system of Hunan, China in 2019 was conducted. Microsoft Excel 2010 was used for preliminary data analysis. The fowllowing descriptive analysis, t-tests, and Chi-Squared tests were carried out using SPSS 25.0. Among 419,971 couples, 182,450 (21.72%) individuals were older than 35 years, 257,471(69.48%) couples planned to have a second or additional child and 114,892 (27.36%) individuals had a history of adverse pregnancy outcomes. The mean number of risk factors of adverse pregnancy outcome was higher in males than that in females (2.17 per male vs 1.92 per female). The prevalence/proportions of hypertension, increased psychological pressure, high alanine transaminase or creatinine, smoking, passive smoke exposure, alcohol use, and exposure to environmental risk factors were higher in males than that in females (2.43% vs 1.35%, 0.68% vs 0.54%, 12.80% vs 5.93%, 2.52% vs 1.47%, 27.70% vs 0.24%, 10.94% vs 3.58%, 15.62% vs 1.07%, and 1.46% vs 1.15%, respectively). The proportion of females with an abnormal cervix was 3.35%, and the proportion of males with abnormal wrapping was 1.90%. The prevalence/proportions of anemia and work-related pressure or social tensions were higher in females than that in males (5.53% vs 0.51%, 15.39% vs 13.61%, and 8.22% vs 7.88%, respectively). History of adverse pregnancy outcomes and age olderthan 35 years were important risk factors for pre-pregnancy couples in Hunan province. The mean number of risk factors was higher in males than that in females. Hypertension, increased psychological pressure, high alanine transaminase and creatinine levels, smoking, passive smoke exposure, alcohol use, and exposure to dangerous environmental factors were the major risk factors for males. Anemia, work-related pressure and social tensions were the major risk factors for females.

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“…However, though limited by the available data in current datasets, in the present study, we did try our best to make the definition of NAFLD as convincible as possible. The code ICD-9-CM 571.8 has been utilized as NAFLD definition in previous studies ( 22 , 51 ). Similarly, ICD-10-CM codes K75.0 (for NAFLD) and K76 (for NASH) were also applied by population-based studies ( 52 , 53 ).…”

Section: Discussionmentioning

confidence: 99%

Bidirectional Association Between Psoriasis and Nonalcoholic Fatty Liver Disease: Real-World Evidence From Two Longitudinal Cohort Studies

et al. 2022

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BackgroundAssociation between nonalcoholic fatty liver disease (NAFLD) and future psoriasis has not yet been confirmed, although the two diseases partially share a common pathogenesis pathway. Studies have revealed an association between psoriasis and subsequent NAFLD; however, these studies were limited to small sample sizes and a cross-sectional study design. Hence, the main objective of this population-based longitudinal cohort study was to evaluate the bidirectional association between psoriasis and NAFLD.MethodsData were retrieved from Taiwan’s National Health Insurance Research Database. Patients with new-onset NAFLD and psoriasis were respectively enrolled in two cohorts. For each comparison cohort, propensity-score-matched controls with no record of NAFLD or psoriasis were selected. An adjusted hazard ratio (aHR) was applied to evaluate subsequent risks.ResultsThe risk of patients with new-onset NAFLD developing psoriasis was statistically significant, with an HR of 1.07 (95% CI, 1.01–1.14). For younger patients with NAFLD, the risk of developing psoriasis was 1.3-fold higher. The risk of patients with new-onset psoriasis developing NAFLD in the future was 1.28-fold higher than that of patients without psoriasis (95% CI, 1.21–1.35), and patients in younger psoriasis subgroups below the age of 40 years were at a higher risk than those in older subgroups, with an aHR of 1.55 (95% CI, 1.40–1.71).ConclusionEvidence supports a bidirectional association between NAFLD and psoriasis, especially in patients below the age of 40 years. The correlation between the two diseases and the subsequent risk of disease development should be considered when caring for patients.

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Non-alcoholic fatty liver disease among patients with sleep disorders: a Nationwide study of Taiwan

Cited by 13 publications

References 52 publications

Autoimmune conditions following mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccination: a descriptive cohort study among 1.1 million vaccinated people in Hong Kong

Autoimmune conditions following mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccination: a descriptive cohort study among 1.1 million vaccinated people in Hong Kong

The risk factors of adverse pregnancy outcome for pre-pregnancy couples in Hunan, China

Bidirectional Association Between Psoriasis and Nonalcoholic Fatty Liver Disease: Real-World Evidence From Two Longitudinal Cohort Studies

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