Non-alcoholic fatty liver: another feature of the metabolicsyndrome?

Cortez‐Pinto, Helena; Camilo, M.; Baptista, António M.; Oliveira, Alexandre G.; Moura, Miguel Carneiro de

doi:10.1016/s0261-5614(99)80015-6

Cited by 259 publications

(178 citation statements)

References 33 publications

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“…Thus, NAFLD may be considered as an additional feature of the metabolic syndrome, with specific hepatic insulin resistance. 72,73 Insulin resistance is associated with various metabolic abnormalities, especially dyslipidaemia (hypertriglyceridaemia, low HDL cholesterol, high levels of small dense LDL, post-prandial hyperlipidaemia), leading to the concept of'metabolic syndrome'. 74 Hyperinsulinaemia has been long recognized in hepatic steatosis, irrespective of weight excess, and fatty liver has been considered to be associated with relative insulin resistance to which elevated FFA may contribute.…”

Section: The Association Of Nash With Insulin Resistance Syndromementioning

confidence: 99%

Obesity and liver disease

Scheen

Luyckx

2002

Best Practice & Research Clinical Endocrinology & Metab

118

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Non-alcoholic steatohepatitis (NASH) is a disease of emerging identity and importance. It is frequently associated with obesity, especially visceral fat, and is intimately related to fatty liver and markers of the insulin resistance syndrome. Both the prevalence and the severity of liver steatosis are related to body mass index, waist circumference, hyperinsulinaemia, hypertriglyceridaemia and impaired glucose tolerance or type 2 diabetes. The identification of obese patients who may progress from steatosis to NASH and from NASH to fibrosis/cirrhosis is an important clinical challenge. Substantial weight loss is accompanied by a marked attenuation of insulin resistance and related metabolic syndrome and, concomitantly, by a remarkable regression of liver steatosis in most patients, although increased inflammation may be detected in some subjects. Thus, NASH may be considered as another disease of affluence, as is the insulin resistance syndrome, and perhaps being part of it, especially in obese patients.

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Section: The Association Of Nash With Insulin Resistance Syndromementioning

confidence: 99%

Obesity and liver disease

Scheen

Luyckx

2002

Best Practice & Research Clinical Endocrinology & Metab

118

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“…4,5 In addition, a significant proportion of obese and overweight people have nonalcoholic fatty liver disease (NAFLD). [6][7][8] Moreover,…”

Section: Introductionmentioning

confidence: 99%

Non‐alcoholic fatty liver disease (NAFLD) is associated with low level of physical activity: a population‐based study

Gerber

Otgonsuren

Mishra

et al. 2012

Aliment Pharmacol Ther

216

117

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“…[6][7][8][9] These patients are at higher risk of developing cirrhosis, 10 terminal liver failure, 10 and hepatocellular carcinoma. 11 NAFLD is mainly associated with obesity, 12,13 diabetes, 6,8,14 hyperdyslipemia, 6,7,15,16 and insulin resistance, [16][17][18][19] which are the main features of the recently characterized metabolic syndrome. 20 The borders of the syndrome, previously known as the insulin-resistance syndrome, 21,22 have long been unsettled.…”

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confidence: 99%

Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome

et al. 2003

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Nonalcoholic fatty liver disease (NAFLD) has been associated with the insulin-resistance syndrome, at present defined as the metabolic syndrome, whose limits were recently set. We assessed the prevalence of the metabolic syndrome in 304 consecutive NAFLD patients without overt diabetes, on the basis of 3 or more criteria out of 5 defined by the U.S. National Institutes of Health (waist circumference, glucose, high-density lipoprotein [HDL]-cholesterol, triglycerides, and arterial pressure). The prevalence of the metabolic syndrome increased with increasing body mass index, from 18% in normal-weight subjects to 67% in obesity. Insulin resistance (Homeostasis Model Assessment method) was significantly associated with the metabolic syndrome (odds ratio [OR], 2.5; 95% CI, 1.5-4.2; P < .001). Liver biopsy was available in 163 cases (54%). A total of 120 patients (73.6%) were classified as having nonalcoholic steatohepatitis (NASH); 88% of them had a metabolic syndrome (vs. 53% of patients with pure fatty liver; P < .0001). Logistic regression analysis confirmed that the presence of metabolic syndrome carried a high risk of NASH among NAFLD subjects (OR, 3.2; 95% CI, 1.2-8.9; P ‫؍‬ .026) after correction for sex, age, and body mass. In particular, the syndrome was associated with a high risk of severe fibrosis (OR, 3.5; 95% CI, 1.1-11.2; P ‫؍‬ .032). In conclusion, the presence of multiple metabolic disorders is associated with a potentially progressive, severe liver disease. The increasing prevalence of obesity, coupled with diabetes, dyslipidemia, hypertension, and ultimately the metabolic syndrome puts a very large population at risk of forthcoming liver failure in the next decades. (HEPATOLOGY 2003;37:917-923.)

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Non-alcoholic fatty liver: another feature of the metabolicsyndrome?

Cited by 259 publications

References 33 publications

Obesity and liver disease

Obesity and liver disease

Non‐alcoholic fatty liver disease (NAFLD) is associated with low level of physical activity: a population‐based study

Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome

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