Non-ablative radio frequency for the treatment of androgenetic alopecia

Tan, Yimei; Liu, Wei; Zhang, Yiyi; Goren, Andy; McCoy, John; Stanimirović, Andrija; Lotti, Torello; Kovacevic, Maja

doi:10.15570/actaapa.2019.39

Cited by 4 publications

(7 citation statements)

References 6 publications

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“…Some of the results described above coincide with those of some studies that have applied RF electrical therapies for the treatment of alopecia. In a single blinded study carried out in a sample of 24 men, the application of non-ablative RF currents increased hair growth compared to the untreated group [21]. Another study with 19 male subjects diagnosed with androgenic alopecia has shown an improvement in the efficacy of the combined treatment of 1 MHz of bipolar RF currents and minoxidil compared to treatment with minoxidil alone [24].…”

Section: Discussionmentioning

confidence: 99%

“…For the calculation of the sample size, data on sizes previously used for other similar studies were used [21,22,24].…”

Section: Discussionmentioning

confidence: 99%

“…Although there are a variety of therapies with varying degrees of efficacy in their application to the treatment of DCD, due to the deficiencies of some of them, the development of new therapies for the treatment of this disorder is considered essential. Recently, RF electrical therapies, alone or in combination with drugs, have generated promising results [21,22,24].…”

Section: Discussionmentioning

confidence: 99%

“…In aesthetic medicine, CRET has been shown to be potentially effective in reducing wrinkles [19,20]. However, with regard to the treatment of CDC, there are few clinical studies performed with RF therapies in general and with CRET treatments in particular, which limits the knowledge about the efficacy and the ideal conditions for the application of these technologies [21][22][23][24]. However, there is a large block of pre-clinical studies that show that, even applied under subthermal conditions, the CRET electrical stimulus has regenerative effects based on the promotion of proliferation and early chondrogenic differentiation of adipose derived human stem cells and human fibroblasts and keratinocytes, as well as of migration in fibroblasts and expression of heat shock proteins and can modulate adipogenic differentiation of human stem cells [11,12,[25][26][27].…”

Section: Introductionmentioning

confidence: 99%

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Radiofrequency Current at 448 Khz For Female Pattern Hair Loss: Cellular Bases For Redensification Improvement

Pablo¹

2022

JDR

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Objective: Capacitive-Resistive Electrothermal Therapies (CRET) have proven effective in tissue regeneration. This study analyzes the response to 448-kHz CRET treatment in 20 patients with Female Pattern Hair Loss (FPHL) and in woman’s Dermal Papilla Cells (DPC). Methods: Patients received ten 20-minute CRET sessions over an 8-week interval. Three months after the last session, the effects of the treatment were trichoscopically analysed. DPC were CRET stimulated intermittently for 12, 24 or 48 h and the effects on cell proliferation and expression of several proteins involved in cell proliferation were analysed. Results: Trichoscopic data revealed generalized, statistically significant hair redensification (10 – 15 % over pre-treatment values) in all the treated scalp areas. In-vitro electrostimulation significantly increased DPC proliferation and expression of the proteins involved in cell proliferation. Since dysregulation of DPC proliferation is the main factor underlying abnormal hair loss, it is likely that electrically-induced DPC proliferation is involved in the redensifying effects obtained in the trichological study. Conclusion: The results of the trichological study in FPHL patients and those of the experimental study in woman’s DPC are consistent with each other and suggest that 448-kHz CRET could be effective both for hair redensification and hair loss prevention.

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Section: Discussionmentioning

confidence: 99%

“…For the calculation of the sample size, data on sizes previously used for other similar studies were used [21,22,24].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Radiofrequency Current at 448 Khz For Female Pattern Hair Loss: Cellular Bases For Redensification Improvement

Pablo¹

2022

JDR

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“…It uses high frequency alternating current to produce a controlled increase in tissue temperature with the goal of inducing thermal damage to stimulate changes in collagen conformation and new collagen formation in deep layers of the skin and subcutaneous tissue 9 . A previous single‐blinded study comparing a nonablative fractional RF device and a sham device observed a larger increase in hair growth among patients in the treatment group, though results did not reach significance due to the small sample size 10 . Another single center, single‐blinded prospective study showed increases in both hair counts and hair shaft thickness with use of a fractional RF device 11 .…”

Section: Introductionmentioning

confidence: 99%

Nonablative radiofrequency for the treatment of androgenetic alopecia: An open‐label study

Lim

Verner

Wambier

et al. 2021

Dermatological Reviews

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Introduction Androgenetic alopecia (AGA) is the most common type of progressive hair loss, and current treatments are limited. Wound healing has been associated with hair regrowth; consequently, its mechanism has been suggested for treatment of hair loss. Nonablative radiofrequency (RF), which induces wound healing mechanisms through thermal damage, has been shown to increase hair growth when applied to the scalp. In this study, we aim to evaluate a specially adapted non‐ablative RF device as a noninvasive, nonsystemic treatment for AGA. Methods An open‐label study was conducted to evaluate the efficacy of a nonablative RF device for treatment of AGA. Patients diagnosed with Hamilton–Norwood Stage 3 or above were recruited and received 10 weekly RF treatment sessions. Hair counts were performed before and after treatment manually by a medical resident. Results Ten male and 10 female subjects were recruited. Hair count, hair density (per cm2), vellus hair density (per cm2), terminal hair density (per cm2), cumulative thickness (mm/cm2), number of follicular units, density of follicular units (per cm2), and average hair per unit increased from before to after treatment. Only the increases in hair count, overall hair density, terminal hair density, cumulative thickness, and average hair count/unit were statistically significant (p < .05). Discussion We observed significant improvement in hair growth in 19 out of 20 patients. Overall, significant improvement was observed in total hair counts, terminal hair counts, hair shaft thickness, and in the number of follicular units. Further clinical research is warranted to further explore nonablative RF for treatment of AGA.

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Immune cell interactions with the stem cell niche

Wang

2023

Advances in Stem Cells and Their Niches

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Non-ablative radio frequency for the treatment of androgenetic alopecia

Abstract: Subjects completed the study with an average of 3.63 sessions. The average increase in hair counts from baseline in the treatment group was higher than the placebo group 22.8% vs 9.6% (p = 0.08).

Cited by 4 publications

References 6 publications

Radiofrequency Current at 448 Khz For Female Pattern Hair Loss: Cellular Bases For Redensification Improvement

Radiofrequency Current at 448 Khz For Female Pattern Hair Loss: Cellular Bases For Redensification Improvement

Nonablative radiofrequency for the treatment of androgenetic alopecia: An open‐label study

Immune cell interactions with the stem cell niche

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