Non-01 Vibrio cholerae septicemia and meningitis in a neonate

Kerketta, Joshi Anand; Paul, Alexander Chandran; Balaji, V; Kirubakaran, Chellam; Mv, Jesudason; Moses, Prabhakar D.

doi:10.1007/bf02723720

Cited by 24 publications

(7 citation statements)

References 8 publications

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“…9 Nontoxigenic V. cholerae non-O1/non-O139 is rare in neonates, with only eight previous published cases. 11,12,13,14 The majority of these cases (7/8) presented with meningoencephalitis and had residual neurological deficits following infection. 11,12,13,14) In the remaining case, 15 the patient presented with fever, did not have a LP and demised in hospital.…”

Section: Discussionmentioning

confidence: 99%

“…11,12,13,14 The majority of these cases (7/8) presented with meningoencephalitis and had residual neurological deficits following infection. 11,12,13,14) In the remaining case, 15 the patient presented with fever, did not have a LP and demised in hospital. This is in contrast with the clinical findings in our case, where the patient recovered well, had a normal CSF analysis, had a negative repeat blood culture (whilst on empiric antibiotics) and had a repeat CRP that was not elevated.…”

Section: Discussionmentioning

confidence: 99%

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Non-toxigenic Vibrio cholerae non-O1/non-O139 pseudo-bacteraemia in a neonate: A case report

Dowling

Westhuyzen

Haumann³

et al. 2021

Southern African Journal of Infectious Diseases

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Toxigenic Vibrio cholerae O1/O139 is causative of cholera, which is a well characterised potentially epidemic gastrointestinal disease. Less is known about the pathogenesis and clinical presentation of non-toxigenic V. cholerae non-O1/non-O139, although they are increasingly implicated in human disease globally, have been isolated from various South African water sources and can contaminate the environment. The authors describe a case of pseudo-bacteraemia with non-toxigenic V. cholerae non-O1/non-O139 in a neonate.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Non-toxigenic Vibrio cholerae non-O1/non-O139 pseudo-bacteraemia in a neonate: A case report

Dowling

Westhuyzen

Haumann³

et al. 2021

Southern African Journal of Infectious Diseases

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“…Based on in vitro susceptibility tests, V. cholerae (non-O1) strains are generally susceptible to most of antimicrobial agents (10). Although the treatment of choice for V. cholerae is tetracycline, the patient was successfully treated with linezolid, imipenem and levofloxacin.…”

Section: Discussionmentioning

confidence: 99%

Vibrio cholerae non-O1,non-O139 Isolated from Pleural Effusion Following Total Gastrectomy

Suk

Lee

et al. 2006

J Korean Med Sci

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We isolated non-O1, non-O139 Vibrio cholerae from pleural effusion in a patient with recurred advanced gastric caner after total gastrectomy. We also recovered the organism from the patient's stool culture. The patient did not experience gastrointestinal symptoms such as diarrhea except heartburn and epigastric discomfort from stomach cancer before admission. The suspected route of infection is directly from the gastrointestinal tract through the previous surgical wounds. After antibiotic treatment, no more V. cholerae was isolated and the patient was well discharged from the hospital. This is the first report of V. cholerae infection associated with pleural effusion in a long-term latent carrier of the organism.

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“…It has been suggested that the emergence of V. cholerae O139 is the result of a complex chromosomal rearrangement involving the horizontal transfer of genes encoding enzymes involved in O-specific polysaccharide biosynthesis (Comstock et al 1996;Mukhopadhyay et al 1998). However, choleralike diseases are also caused by other non-O1 serotypes (Janda et al 1988;Kerketta et al 2002). Their genes may be possibly rearranged and they will acquire genes responsible for cholera disease outbreak.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulative properties of conjugates composed of detoxified lipopolysaccharide and capsular polysaccharide of Vibrio cholerae O135 bound to BSA-protein carrier

et al. 2010

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O135 serotype Vibrio cholerae isolated from Slovak river was used as a source of surface polysaccharide antigens. Following detoxification procedure, fractions of polysaccharides were separated by size exclusion chromatography. Two resultant fractions were the capsular polysaccharide (Mw ∼ 197,000 Da) and the lipopolysaccharide fragment (Mw ∼ 13,300 Da). These materials were used for preparation of four novel glycoconjugates. Two of them containing detoxified lipopolysaccharide as antigen were prepared by original chemical method using the new biocompatible polymer as carrier of antigen. Additionally, other two conjugates were prepared by direct linking of capsular and detoxified lipopolysaccharide antigens to the protein carrier using adipic acid dihydrazide spacer. The immunogenicities (induced IgM, IgG, IgA antibodies) of all conjugates were determined by enzyme-linked immunosorbent assay. Polymer containing conjugates elicited higher levels of specific anti-lipopolysaccharide IgM and IgG antibodies in comparison with other conjugates without polymer carrier. Enhanced IgM vibriocidal activity of mice antisera was also evident here.

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Non-01 Vibrio cholerae septicemia and meningitis in a neonate

Abstract: Non-O1 Vibrio cholerae is known to cause diarrhoea as well as extra-intestinal infections in adults and children. However meningitis in children is a rare occurrence. We report a neonate who developed septicemia and meningitis due to Non-O1 Vibrio cholerae.

Cited by 24 publications

References 8 publications

Non-toxigenic Vibrio cholerae non-O1/non-O139 pseudo-bacteraemia in a neonate: A case report

Non-toxigenic Vibrio cholerae non-O1/non-O139 pseudo-bacteraemia in a neonate: A case report

Vibrio cholerae non-O1,non-O139 Isolated from Pleural Effusion Following Total Gastrectomy

Immunomodulative properties of conjugates composed of detoxified lipopolysaccharide and capsular polysaccharide of Vibrio cholerae O135 bound to BSA-protein carrier

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