Noise Effects on the Cochlear Vasculature in Normotensive and Spontaneously Hypertensive Rats

Axelsson, A.; Borg, Erik; Hornstrand, Charlotte

doi:10.3109/00016488309132894

Cited by 34 publications

(8 citation statements)

References 12 publications

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“…Chronic hypertension has also been implicated in the development of hearing loss 3,8 . Studies have documented that chronic hypertension potentiates noise‐induced decreases in cochlear function and the development of histologic cochlear damage 9,10 . A significant relationship among hypertension, age, and hearing loss in an animal model has also been confirmed 11 …”

Section: Introductionmentioning

confidence: 92%

Interaction Between Hypertension and Diabetes Mellitus in the Pathogenesis of Sensorineural Hearing Loss

Prazma

et al. 1997

The Laryngoscope

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The purpose of this study is to support the hypothesis that diabetic end-organ damage of the cochlea is augmented in the setting of hypertension. A historical perspective reviewing the effects of diabetes and hypertension as causative factors in the development of sensorineural hearing loss, as well as the basic epidemiology and pathophysiology of the renal and vascular effects of diabetes and hypertension, is presented. The results of audiologic findings in insulin-dependent diabetic patients, both normotensive and hypertensive, were analyzed and correlated with the results of animal studies to support the hypothesis that sensorineural hearing loss in patients and cochlear hair cell loss in animal studies result from the effects of hypertension in conjunction with insulin-dependent diabetes mellitus.

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Section: Introductionmentioning

confidence: 92%

Interaction Between Hypertension and Diabetes Mellitus in the Pathogenesis of Sensorineural Hearing Loss

Prazma

et al. 1997

The Laryngoscope

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“…The availability of genetically distinct strains of rats and mice have made these useful for discovering genetic contributions to the severity of noise injury. Within rats (Borg, 1982;Axelsson et al, 1983) and mice (Henry, 1982;Li, 1992;Erway et al, 1996;Yoshida et al, 2000;Candreia et al, 2004;Vazquez et al, 2004), different strains show marked variation in noise susceptibility. In mice, moreover, several genetic loci that can mediate such differences are known e.g., (Ohlemiller et al, 1999;Ohlemiller et al, 2000;Davis et al, 2001;Kozel et al, 2002;Davis et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Genetic dependence of cochlear cells and structures injured by noise

Ohlemiller¹,

Gagnon²

2007

Hearing Research

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The acute and permanent effects of a single damaging noise exposure were compared in CBA/J, C57BL/6 (B6), and closely related strains of mice. Two hrs of broadband noise (4-45 kHz) at 110 dB SPL led to temporary reduction in the endocochlear potential (EP) of CBA/J and CBA/CaJ (CBA) mice and acute cellular changes in cochlear stria vascularis and spiral ligament. For the same exposure, B6 mice showed no EP reduction and little of the pathology seen in CBA. Eight weeks after exposure, all mice showed a normal EP, but only CBA mice showed injury and cell loss in cochlear lateral wall, despite the fact that B6 sustained larger permanent threshold shifts. Examination of noise injury in B6 congenics carrying alternate alleles of genes encoding otocadherin (Cdh23), agouti protein, and tyrosinase (albinism) indicated that none of these loci can account for the strain differences observed. Examination of B6xCBA F1 mice and F1xB6 N2 mice further indicated that susceptibility to noise-related EP reduction and associated cell pathology are inherited in an autosomal dominant manner, and are established by one or a few large effect quantitative trait loci. Findings support a common genetic basis for an entire constellation of noise related cochlear pathologies in cochlear lateral wall and spiral limbus. Even within species, cellular targets of acute and permanent cochlear noise injury may vary with genetic makeup.

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“…At very high sound exposure levels (120-155 dB), the reduction in cochlear blood flow (CBF) and local vasoconstriction can be quite dramatic [Perlman and Kimura, 1962;Quirk et al, 1992], such that the cochlea is subject to severe hypoperfusion. The observed vascular changes affect the major arterioles supplying the cochlea, as well as the radiating arterioles and capillary beds [Hawkins, 1971;Axelsson et al, , 1983, resulting in decreased CBF Scheibe et al, 1993], vasoconstriction [Hawkins, 1971;Vertes et al, 1981;Quirk et al, 1992], aggregation of red blood cells [Hawkins, 1971;, and increased pericyte diameter .…”

Section: Introductionmentioning

confidence: 99%

8-Iso-Prostaglandin F<sub>2α</sub>, a Product of Noise Exposure, Reduces Inner Ear Blood Flow

Miller

Brown

Schacht³

2003

Audiol Neurotol

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Noise exposure induces the formation in the cochlea of 8-isoprostaglandin F_2α (8-iso-PGF_2α), a marker for reactive oxygen species [Ohinata et al., 2000a] and a potent vasoconstrictor, raising the possibility that 8-iso-PGF_2α may be responsible for noise-induced reductions in cochlear blood flow (CBF). To test this hypothesis, CBF was assessed in the guinea pig in response to ‘local’ (via the anterior inferior cerebellar artery) and systemic (i.v.) delivery of 8-iso-PGF_2α using laser Doppler flowmetry. Local 8-iso-PGF_2α induced a clear reduction in CBF. With systemic infusion, vascular conductance (VC), the ratio of CBF to systemic blood pressure, decreased in a dose-dependent manner up to 30%, consistent with an 8-iso-PGF_2α-induced constriction of the cochlear vasculature. Infusion of SQ29548, a specific antagonist of 8-iso-PGF_2α, appropriately blocked an 8-iso-PGF_2α-induced CBF response. Similarly, noise-induced changes in CBF and VC were prevented by infusion of SQ29548 during noise exposure or by antioxidant treatment (glutathione monoethyl ester) prior to exposure. Prevention of isoprostane-mediated vasoconstriction may have clinical utility in the protection from noise-induced hearing loss.

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Noise Effects on the Cochlear Vasculature in Normotensive and Spontaneously Hypertensive Rats

Cited by 34 publications

References 12 publications

Interaction Between Hypertension and Diabetes Mellitus in the Pathogenesis of Sensorineural Hearing Loss

Interaction Between Hypertension and Diabetes Mellitus in the Pathogenesis of Sensorineural Hearing Loss

Genetic dependence of cochlear cells and structures injured by noise

8-Iso-Prostaglandin F<sub>2α</sub>, a Product of Noise Exposure, Reduces Inner Ear Blood Flow

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