Nodular hidradenoma of the wrist with spontaneous regression in a 7‐month‐old infant

Lee, Young Bok; Song, Eun Jong; Park, Sae Mi; Kim, Jin-Wou; Yu, Dong

doi:10.1111/ijd.12539

Cited by 5 publications

(6 citation statements)

References 5 publications

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“…Few cases of CCH located at the level of the limbs were reported. Three of them were observed at the upper limb during skeletal growth and they had three different location: arm, forearm and wrist [ 7 , 11 , 12 ]. Two of them had a successful surgical excision without recurrence [ 7 , 11 ], while the third, observed in a 7-month old boy and located at wrist, was left untreated and spontaneously regressed in three months.…”

Section: Discussionmentioning

confidence: 99%

Clear cell hidradenoma of the hand: A case report in an 83-year old patient

Efremov

Caterini

Petrungaro

et al. 2020

International Journal of Surgery Case Reports

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Highlights Clear Cell Hidradenoma (CCH) is a benign tumor of the sweat glands that very rarely appear on the hand. CCH needs to be considered as a possible diagnosis for small subcutaneous masses on the extremities in all ages. Accurate surgical excision is the treatment of choice, to avoid recurrence. Histological analysis is fundamental for a correct diagnosis.

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Section: Discussionmentioning

confidence: 99%

Clear cell hidradenoma of the hand: A case report in an 83-year old patient

Efremov

Caterini

Petrungaro

et al. 2020

International Journal of Surgery Case Reports

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“…On the other hand, the hypothesis of a cutaneous hidradenoma which has regressed after spreading to a lymph node cannot be completely ruled out. Indeed, a spontaneously regressive cutaneous hidradenoma has recently been related by Lee et al…”

Section: Discussionmentioning

confidence: 94%

Lymph node location of a clear cell hidradenoma: report of a patient and review of literature

et al. 2016

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Cutaneous clear cell hidradenoma is an uncommon benign adnexal tumor which is not supposed to metastasize, contrary to its rare malignant counterpart, hidradenocarcinoma. We report the case of a 49-year-old man, who had had a stable inguinal lymph node enlargement for 6 years. An excision was performed and revealed an intra-nodal tumor, made of large clear cells with abundant cytoplasm and round nuclei without atypia or mitosis. The immunohistochemical staining showed diffuse positivity for keratin AE1/AE3, keratin 5/6 and p63, and focal staining with keratin 7, epithelial membrane antigen (EMA) and carcinous epithelial antigen (CEA), which underlined some ductular structures. Tumor cells were negative for renal markers PAX8 and CD10. Ki67 stained less than 1% of tumor cells. A translocation involving MAML2 gene was evidenced by fluorescence in situ hybridization (FISH) analysis. No primary cutaneous tumor was found after extensive examination. Altogether, these results are in favor of an isolated nodal hidradenoma, for which we discuss two hypothesis: a primary nodal lesion, or a 'benign metastasis' of a cutaneous tumor. Cases of morphologically benign hidradenoma with lymph node involvement are exceptional. Our case, similar to every other reported case, was associated with an excellent prognosis, supporting the idea that these patients should not be overtreated.

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“…In fact, a case of cutaneous CCH has been observed to spontaneously regress after a punch biopsy. 13 Some limitations should be noted. First, one of our cases had a short follow-up, and it may be too early to rule out any further recurrence.…”

Section: Discussionmentioning

confidence: 99%

Three Cases of Clear Cell Hidradenoma With “Benign” Lymph Node Involvement

González‐López

Garrido-Ruiz

Ríos‐Martín

et al. 2021

The American Journal of Dermatopathology

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The malignant counterpart of cutaneous clear cell hidradenoma (CCH), hidradenocarcinoma, is an aggressive neoplasm that may have a fatal outcome. However, some cases of benign looking CCH with isolated lymph node involvement and excellent prognosis have been described. "CCH-like neoplasm of uncertain malignant potential" or "atypical hidradenoma" have been proposed as designations for these lesions. We report 3 cases of CCH with lymph node involvement. Ages ranged from 29 to 51 years old. All cases involved the inguinal lymph nodes: 2 of them presented with an isolated lymph node lesion, and the third case had lymph node and cutaneous involvement following the resection of a previous cutaneous lesion. Imaging studies showed no systemic involvement. None of the lesions exhibited histopathologic features of malignancy. All neoplasms were well circumscribed, had cystic spaces, did not display atypia or necrosis, and had less than 4 mitoses per high power field. No recurrence has been observed at followup after resection in all cases. All published cases of CCH with lymph node involvement so far affected a single lymph node in the axillary or inguinal regions, lacked features of malignancy, and had excellent longterm prognosis. Some cases previously reported as hidradenocarcinoma probably fit into this category. Our series adds more evidence to this rare phenomenon of "benign metastasis." Aggressive treatment should be avoided in these cases, and a long-term follow-up is warranted.

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Nodular hidradenoma of the wrist with spontaneous regression in a 7‐month‐old infant

Cited by 5 publications

References 5 publications

Clear cell hidradenoma of the hand: A case report in an 83-year old patient

Clear cell hidradenoma of the hand: A case report in an 83-year old patient

Lymph node location of a clear cell hidradenoma: report of a patient and review of literature

Three Cases of Clear Cell Hidradenoma With “Benign” Lymph Node Involvement

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