Nodular gastritis in adults: Clinical features, endoscopic appearance, histopathological features, and response to therapy

Dwivedi, Manisha; Misra, Sri Prakash; Misra, Vatsala

doi:10.1111/j.1440-1746.2007.05044.x

Cited by 21 publications

(25 citation statements)

References 16 publications

(19 reference statements)

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“…Other reasons for variability in prevalence rate could be related to differences in the study design, host, bacterial or environmental factors. Similar to previous studies [3,13] , we found that female patients were more commonly affected than males. This higher female proportion goes against the concept that H. pylori infection has no gender predilection.…”

Section: Discussionsupporting

confidence: 81%

“…In support of the idea that H. pylori infection could be the main inducer of the nodular pattern in NG, Dwivedi et al [13] reported that 87.5% of NG patients showed complete normalization of the gastric mucosa following anti-H. pylori therapy. Koh et al [32] found that the increase in gastritis score was dependent on the increase in H. pylori density and was significantly associated with the occurrence of NG.…”

Section: Discussionmentioning

confidence: 83%

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Endoscopic Nodular Gastritis in Dyspeptic Adults: Prevalence and Association with <i>Helicobacter pylori</i> Infection

Alenezi¹,

Alsurayei²,

Aly

et al. 2009

Med Princ Pract

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Objective: To determine the prevalence and histological features of endoscopic nodular gastritis (NG) in adult dyspeptic patients and its relation to Helicobacter pylori infection. Subjects and Methods: A retrospective endoscopic report review of 2,142 patients identified 67 patients with NG during the period from 1 September 2006 to 31 August 2007. A subset of 32 NG patients (group 1) who had had gastric biopsies during upper gastrointestinal endoscopy and had been evaluated for H. pylori infection were compared to 32 age- and gender-matched dyspeptic patients. They had undergone endoscopy during the same period, which yielded normal results, and had available biopsies that were similarly evaluated for H. pylori infection (controls, group 2). Pertinent clinical data were obtained from the patients’ records. An experienced pathologist assessed the biopsies for the presence and grade of inflammation, activity, glandular atrophy, intestinal metaplasia, presence and density of H. pylori and presence of lymphoid follicles or aggregates. Results: NG was identified in 67 (3.1%) patients. On histological examination, group 1 had a significantly higher grade of gastritis (p < 0.001). The presence and density of H. pylori infection was significantly higher in group 1 (p < 0.001). The H. pylori density correlated significantly with the severity of gastritis (r = 0.57, p < 0.001). The endoscopic performance of NG on H. pylori infection had high specificity (96.8%) and positive predictive value (93.3%). Conclusion: This study outlined the clinicopathological features of NG identified among a cohort of dyspeptic patients in Kuwait and confirmed the close association with H. pylori infection. However, our study has a limitation in that histopathologic assessment of all NG patients was not feasible.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 83%

Endoscopic Nodular Gastritis in Dyspeptic Adults: Prevalence and Association with <i>Helicobacter pylori</i> Infection

Alenezi¹,

Alsurayei²,

Aly

et al. 2009

Med Princ Pract

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show abstract

“…However, the definition and clinical importance of NG and associated histopathology could be clarified by prospective long-term follow-up studies including large number of patients. Present data give us the impression that NG would not indicate a new therapeutic approach in addition to the current measures for H. pylori infection [8].…”

Section: Discussionmentioning

confidence: 95%

What Are the Clinical Implications of Nodular Gastritis? Clues from Histopathology

et al. 2009

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There is no widely accepted histopathological definition for nodular gastritis. In this study we aim to uncover the pathologic entity responsible for the nodular appearance and to find clues about the clinical implications of nodular gastritis. Antral biopsy specimens of 160 patients with nodular gastritis and 133 patients without nodular gastritis were examined by an experienced pathologist for dysplasia, foveolar hyperplasia, inflammatory activity, intraepithelial lymphocytosis, intestinal metaplasia, and lymphoid follicle/aggregate formation, and comparative analysis was performed between the two groups of patients. The presence of intraepithelial lymphocytosis was more frequent in patients with nodular gastritis (P < 0.05). There was no difference between the two groups regarding the other pathological features such as presence of dysplasia, inflammatory activity, intestinal metaplasia, lymphoid hyperplasia, and Helicobacter pylori (H. pylori) infection. Increase of intraepithelial lymphocytes may contribute to formation of macroscopical nodules in this peculiar type of gastritis. Nodular gastritis would not indicate a new therapeutic approach in addition to the current measures for Helicobacter pylori infection.

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“…However, to date, we have not been able to identify the predictive factors for symptomatic relief after H. pylori eradication therapy despite several large-scale trials. Although there is no definite consensus regarding the association between symptoms and endoscopic findings, a recent study reported that patients with nodular gastritis exhibited a clinical amelioration of symptoms after H. pylori eradication therapy, and this is correlated with the endoscopic resolution of nodularity [27]. Nodular gastritis is generally more common among younger patients with mild atrophic mucosa [28].…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Eradication Therapy Ameliorates Latent Digestive Symptoms in Chronic Atrophic Gastritis

et al. 2018

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Background/Aims: This study investigated the effect of Helicobacter pylori eradication therapy on latent digestive symptoms in chronic atrophic gastritis. Methods: We enrolled 650 health checkup patients who underwent eradication therapy for chronic gastritis and completed a self-report questionnaire before and after the treatment between January 2014 and December 2016 at the Japanese Red Cross Society Kyoto Daiichi Hospital. Results: H. pylori eradication therapy for chronic atrophic gastritis improved latent digestive symptoms, including both the acid reflux and dyspepsia components in the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) scores. The effect was sustained until 1 year after the treatment. Higher FSSG scores (≥8 points) before H. pylori eradication therapy and age <70 years were significantly associated with the improvement of digestive symptoms after H. pylori eradication therapy. Conclusion: H. pylori eradication therapy may improve patients’ quality of life through the resolution of latent abdominal symptoms.

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Nodular gastritis in adults: Clinical features, endoscopic appearance, histopathological features, and response to therapy

Abstract: The symptoms of NG and endoscopic features regress significantly after H. pylori therapy with a proton pump inhibitor and two antibiotics and should routinely be given to treat this form of gastritis. This may prevent progression to further complications.

Cited by 21 publications

References 16 publications

Endoscopic Nodular Gastritis in Dyspeptic Adults: Prevalence and Association with <i>Helicobacter pylori</i> Infection

Endoscopic Nodular Gastritis in Dyspeptic Adults: Prevalence and Association with <i>Helicobacter pylori</i> Infection

What Are the Clinical Implications of Nodular Gastritis? Clues from Histopathology

Helicobacter pylori Eradication Therapy Ameliorates Latent Digestive Symptoms in Chronic Atrophic Gastritis

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