Nocturnal oxygen therapy as an option for early COVID-19

Shen, Chongxing; Yue, Xiaofeng; Wang, Jianwu; Chen, Shi; Li, Weibing

doi:10.1016/j.ijid.2020.06.080

Cited by 13 publications

(15 citation statements)

References 45 publications

(45 reference statements)

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“…Our study identified that in cases of COVID-19, LPV/r treatment maintained statistically significantly higher oxygen saturation values compared with those measured for the group with DRV/r therapy, with a difference of almost 1.89%; but the number of cases that developed acute respiratory failure did not differ significantly between the two groups. Shen et al demonstrated that placing a COVID-19 patient in an nocturnal oxygen-rich environment slowed down viral replication, decreased angiotensin-converting enzyme 2 receptor expression at the target cell, improved antiviral immune response via interferons, T and natural killer cells, and prevented disease progression to the severe form (29).…”

Section: Discussionmentioning

confidence: 99%

Efficiency of antiviral treatment in COVID‑19

et al. 2021

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is responsible for generating a global effort to discover urgent therapeutic solutions to limit the human damage caused by COVID-19. In the period of April to June 2020, 105 patients diagnosed with COVID-19 met the conditions for inclusion in the present study. They were treated with antiviral therapy according to local guidelines: D group (53 cases), treated with darunavir/ritonavir (DRV/r); and K group (52 cases), treated with lopinavir/ritonavir (LPV/r). Patients from the K group required 7.5 days of hospitalization less compared to those from the D group (P<0.001). The blood oxygen saturation values recorded in the groups were statistically different [K group (94.02±3.12%) vs. D group (92.13±4.24%), P=0.010]. The percentage of patients with unsatisfactory clinical evolution were non-significantly higher in the D group compared with the K group [20 (37.74%) vs. 12 (23.08%), P= 0.157]. We did not note statistically significant differences between the two groups tracked considering the values for the Brescia-COVID Respiratory Severity Scale (BCRSS) of the patients with unsatisfactory clinical evolution, nor of the chest CT' evolution after 10 days of therapy. We did not register significant adverse effects after antiviral therapy in the two groups. Antiviral therapy with LPV/r had some favorable results compared to DRV/r in patients with COVID-19. Both therapies were well tolerated.

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Section: Discussionmentioning

confidence: 99%

Efficiency of antiviral treatment in COVID‑19

et al. 2021

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“…No patient at home isolation, but 26% of hospitalized COVID-19 patients of this study were given oxygen therapy. Decreased hypoxiainducible factor 1α (HIF-1α) could hamper SARS-COV-2 viral replication due to early and proper oxygen therapy [38]. Delivery of 100% oxygen under increased atmospheric pressure up to 2.4 atm through hyperbaric oxygen therapy (HBOT) could improve the patients' outcome if administered at the earliest stages of the COVID-19 infection when arterial oxygen concentration has just been noticed reducing [39].…”

Section: Discussionmentioning

confidence: 99%

RT-PCR Mediated Identification of SARS-CoV-2 Patients from Particular Regions of Bangladesh and the Multi-factorial Analysis Considering Their Pre and Post Infection Health Conditions

Akter

Tushi

Mily

et al. 2020

BJI

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Background: SARS-CoV-2 is a type of coronavirus shows bizarre features with fatality rates at 34.4%. The clinical and non-clinical features of COVID-19 might be causative factors for more rapid community spreading compared to MERS and SARS-CoV-1. Objectives: To study the efficacy of RT-PCR based detection of SARS-CoV-2 patients. Besides, the patients' pre and post-infection health conditions depending on selective clinical and nonclinical parameters were analyzed. Materials and Methods: Clinical and non- clinical data were collected from 205 randomly selected COVID-19 patients, identified through RT-PCR from different areas of Bangladesh. The data were analyzed using statistical and analytical tools to illustrate the impact of the pandemic situation on the sufferers. Results: Molecular identification of the patients through RT-PCR has been observed as the most efficient option for detecting SARS-CoV-2 patients. Patients with the smoking habit have been reported to be more prone to the COVID-19 infection; surprisingly the non-smoker female was the worse suffers. The patients aged 60-69 years were the worst sufferers with every adverse health conditions mentioned. Professionally, 28% self-employed male and 8.19% female were infected. The most infected individuals were house wife (32.029%), as next to the health care workers (22.1%). With the increased age group, a decreased number of smokers were found. Nebulization of 5% home and 12% hospital treated patients were provided, with Oxygen for 26% of hospitalized patients. After recovery, combined physical and psychological complications were observed in 19% of male and 11% female. The socioeconomic, environmental and geographical annotations exposed a clear relationship with the rate of infection as revealed from the nonclinical data analysis. Conclusion: RT-PCR proved its specialty in COVID-19 detection. In addition, impacts of different clinical and nonclinical factors on the physical conditions of the nCoV patients were found significant in the research.

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“…Patients with the hyperinflammatory syndrome usually recover, especially if treated with dexamethasone and/or mAb to inflammatory cytokines, and receive supplemental oxygen [ 27 , 28 ]. However, many patients die or develop a chronic multisystem syndrome that involves the respiratory tract and several other extrapulmonary organs [ 7 ].…”

Section: Metabolic Events During Severe Disease and Chronic Sequelaementioning

confidence: 99%

“…The effects are most evident when the diet is deficient in certain nutrients, such as vitamin A. For example, children receiving a vitamin A deficient diet are more susceptible to measles infection [ 34 ] and the same consequence also might apply to Covid-19 infection [ 28 , 34 ]. Dietary effects, such as fiber and fat content, can also impact on susceptibility to some virus infections.…”

Section: Influence Of Nutrition On Outcome Of Infectionmentioning

confidence: 99%