Nocturnal hypoxemia is related to morning negative affectivity in untreated patients with severe obstructive sleep apnea

Kumagai, Hajime; Sawatari, Hiroyuki; Kiyohara, Yuka; Kanoh, Akiko; Asada, Kana; Kawaguchi, Kengo; Arita, Aki; Murase, Yoko; Konishi, Noriyuki; Hoshino, Tetsuro; Hayashi, Mitsuo; Shiomi, Toshiaki

doi:10.1038/s41598-022-25842-7

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…Following episodes of apnoea and hypopnoea, nocturnal hypoxemia is initially associated with impaired respiratory flow; when recovery capacity is exceeded on resumption of pulmonary ventilation, continuous hypoxia occurs due to carbon dioxide retention (25). In addition, at the end of apnea hypopnea episodes, due to increased respiratory effort, microtremors appear, which may produce a transition from sleep to wakefulness, with stage N1 increase and stage N3 and rapid eye movement (REM) decrease (26).…”

Section: Osas Pathogenesismentioning

confidence: 99%

Sleep apnea syndrome associated with gonadal hormone imbalance (Review)

Cojocaru,

Pohaci‑Antonesei

et al. 2023

Biomed Rep

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Patients with obstructive sleep apnea exhibit an increased risk of developing gonadal disorders. Because a notable number of people worldwide have sleep respiratory and reproductive disorders, it is essential to recognize the association between local upper airway dysfunction and its gonadal effects. Repeated breathing pauses cause sleep fragmentation, disorganization of sleep cycles and stages, sympathetic activation, intermittent hypoxemia and systemic inflammation. Nocturnal intermittent hypoxemia has a direct central effect on neurotransmitters, with disturbances in the normal production of hypothalamic-pituitary hormones. Awakenings and micro-awakenings at the end of apneic episodes produce a central stress responsible for hormonal changes and subsequent endocrine imbalances. The aim of the present study was to investigate the impact of obstructive sleep apnea syndrome (OSAS) on gonadal hormonal homeostasis and its consequences. Recognizing and understanding how local upper airway dysfunction causes gonadal imbalance may facilitate better care for patients with OSAS. Although there may be a direct relationship between sleep-disordered breathing and gonadal function mediated by hormones via the hypothalamicpituitary-gonadal axis, to date, current therapies have not been effective.

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Section: Osas Pathogenesismentioning

confidence: 99%

Sleep apnea syndrome associated with gonadal hormone imbalance (Review)

Cojocaru,

Pohaci‑Antonesei

et al. 2023

Biomed Rep

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The clinical influence of nasal surgery on PAP compliance and optimal application among OSA subjects uncomfortable with PAP device wear

Cha

Sun

et al. 2023

Sci Rep

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This study aimed to evaluate the alteration of PAP compliance after nasal surgery and to determine the optimal indications of nasal surgery in obstructive sleep apnea (OSA) subjects. Among OSA subjects using PAP devices, 29 subjects who underwent septoturbinoplasty due to nasal obstruction were included and their pre- and postoperative medical and PAP records were reviewed retrospectively. Postoperative autoPAP usage data was further assessed by grouping the compliance (the percentage of days with usage ≥ 4 h) data (group 1: the good compliance group; group 2: the poor compliance group). The data showed that 56% of subjects in group 1 complained of nasal obstruction as the only barrier to using a PAP device and about 89% reported experiencing the efficacy of PAP usage. Both the mean and peak average PAP pressures were significantly reduced in group 1 following nasal surgery. Group 2 had multiple subjective problems that interfered with wearing a PAP device and reported a lack of experiencing the efficacy of PAP usage. Preoperative nasal cavity volume values were smaller and absolute blood eosinophil counts were significantly lower in group 1. The current data demonstrate that nasal surgery might increase the compliance of PAP device wear in OSA subjects who complained of only nasal obstruction as a barrier to wearing PAP and who had small nasal cavity volumes combined with allergic inflammation.

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Nocturnal hypoxemia is related to morning negative affectivity in untreated patients with severe obstructive sleep apnea

Cited by 2 publications

References 41 publications

Sleep apnea syndrome associated with gonadal hormone imbalance (Review)

Sleep apnea syndrome associated with gonadal hormone imbalance (Review)

The clinical influence of nasal surgery on PAP compliance and optimal application among OSA subjects uncomfortable with PAP device wear

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