Nocturnal hypertension in mice consuming a high fructose diet

Farah, Vera; Elased, Khalid M.; Chen, Yanfang; Key, Mary; Cunha, Tatiana Sousa; Irigoyen, Maria Cláudia; Morris, Mariana

doi:10.1016/j.autneu.2006.05.006

Cited by 106 publications

(161 citation statements)

References 58 publications

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“…Contrary to other studies in males (3,5,11,12), our data showed that fructose-fed female rats presented increased body weight gain, which can be explained by the form in which fructose was provided (water vs chow) and by gender differences (5,11,13).…”

contrasting

confidence: 99%

“…Previous studies reported an increase in AP in fructose-fed males by indirect systolic AP measurement by the tail-cuff method and direct AP evaluation by telemetry (5,9). However, AP evaluated indirectly (tail-cuff method) did not change in female rats after fructose treatment in chow (11).…”

mentioning

confidence: 93%

“…Consumption of large quantities of fructose by humans and animals leads to insulin resistance, lipid abnormalities, obesity, hypertension and renal dysfunction (1)(2)(3)(4)(5). The cluster of these metabolic alterations, which are related to increased cardiovascular risk, is known as metabolic syndrome, and has reached epidemic levels in the world (1).…”

mentioning

confidence: 99%

“…An association between hyperinsulinemia and hypertension in humans and animals has been demonstrated (4,7). However, the role of the autonomic nervous system in metabolic and cardiovascular dysfunctions induced by high fructose diet is not well understood, mainly regarding Vagal dysfunction in fructose-fed female rats www.bjournal.com.br the female gender (5,6,8).…”

mentioning

confidence: 99%

“…Previous studies demonstrated that a high fructose intake in experimental animals leads not only to metabolic alterations, but also to cardiovascular, renal and autonomic dysfunction that are frequently accompanied by activation of sympathetic and renin-angiotensin systems (2)(3)(4)(5)(6)). An association between hyperinsulinemia and hypertension in humans and animals has been demonstrated (4,7).…”

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confidence: 99%

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Parasympathetic dysfunction is associated with insulin resistance in fructose-fed female rats

Brito

Ponciano

Figueroa

et al. 2008

Braz J Med Biol Res

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The objective of the present study was to identify metabolic, cardiovascular and autonomic changes induced by fructose overload administered in the drinking water of rats for 8 weeks. Female Wistar rats (200-220 g) were divided into 2 groups: control (N = 8) and fructose-fed rats (N = 5; 100 mg/L fructose in drinking water for 8 weeks). The autonomic control of heart rate was evaluated by pharmacological blockade using atropine (3 mg/kg) and propranolol (4 mg/kg). The animals were submitted to an intravenous insulin tolerance test (ITT) and to blood glucose measurement. The fructose overload induced a significant increase in body weight (~10%) and in fasting glycemia (~28%). The rate constant of glucose disappearance (KITT) during ITT was lower in fructose-fed rats (3.25 ± 0.7%/min) compared with controls (4.95 ± 0.3%/min, P < 0.05) indicating insulin resistance. The fructose-fed group presented increased arterial pressure compared to controls (122 ± 3 vs 108 ± 1 mmHg, P < 0.05) and a reduction in vagal tonus (31 ± 9 vs 55 ± 5 bpm in controls, P < 0.05). No changes in sympathetic tonus were observed. A positive correlation, tested by the Pearson correlation, was demonstrable between cardiac vagal tonus and KITT (r = 0.8, P = 0.02). These data provided new information regarding the role of parasympathetic dysfunction associated with insulin resistance in the development of early metabolic and cardiovascular alterations induced by a high fructose diet.

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confidence: 99%

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Parasympathetic dysfunction is associated with insulin resistance in fructose-fed female rats

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Figueroa

et al. 2008

Braz J Med Biol Res

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Neurochemical Effects of Western Diet Consumption on Human Brain

Farooqui

2015

Diet and Exercise in Cognitive Function and Neurological Diseases

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Modulation of renin angiotensin system components by high glucose levels in the culture of collecting duct cells

Leite

Aragão

Nogueira

et al. 2019

Journal Cellular Physiology

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Diabetes mellitus and its complications have become a major health concern in Western countries. Increased activity of the intrarenal renin-angiotensin system (RAS) contributes to diabetic nephropathy (DN). We previously reported that in mesangial cells, the high glucose concentration (HG) leads to upregulation of angiotensin-converting enzyme (ACE) messenger RNA, suggesting that ACE was modulated by angiotensin II (Ang II) release. However, this relation in the collecting duct has not yet been studied. We, therefore, aimed to evaluate RAS modulation in inner medullary collecting duct cells (IMCD) exposed to HG. The IMCD were divided into normal glucose (5 mM D-glucose, NG), high glucose (30 mM, HG), and mannitol (30 mM, M) groups. The cells were cultured 48 hr in their respective media. The intracellular and extracellular ACE activity was measured using hippuryl-His-Leu as substrate via a fluorimetric assay and expression was analyzed using western blot analysis. ACE activity, intracellular (27%) and extracellular (22%), was significantly lower in the HG group than in NG and M. ACE2 activity and Ang 1-7 levels were higher in the intracellular compartment. Our data suggest that the HG cannot modify ACE synthesis in IMCD cells but can modulate its activity. The decrease in ACE activity may result in decreased levels of Ang II to protect the IMCD against proliferative and inflammatory deleterious effects of this peptide. Conversely, the increase of ACE2 generating high levels of Ang 1-7, a vasodilator peptide, suggesting that this peptide can induce glucose uptake and protect cells against oxidative stress, which can elicit insulin resistance. K E Y W O R D Scollecting duct, diabetes, high glucose, mIMCD-3, renin-angiotensin system

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Nocturnal hypertension in mice consuming a high fructose diet

Cited by 106 publications

References 58 publications

Parasympathetic dysfunction is associated with insulin resistance in fructose-fed female rats

Parasympathetic dysfunction is associated with insulin resistance in fructose-fed female rats

Neurochemical Effects of Western Diet Consumption on Human Brain

Modulation of renin angiotensin system components by high glucose levels in the culture of collecting duct cells

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