2008
DOI: 10.1590/s0100-879x2008005000030
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Abstract: The objective of the present study was to identify metabolic, cardiovascular and autonomic changes induced by fructose overload administered in the drinking water of rats for 8 weeks. Female Wistar rats (200-220 g) were divided into 2 groups: control (N = 8) and fructose-fed rats (N = 5; 100 mg/L fructose in drinking water for 8 weeks). The autonomic control of heart rate was evaluated by pharmacological blockade using atropine (3 mg/kg) and propranolol (4 mg/kg). The animals were submitted to an intravenous i… Show more

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Cited by 57 publications
(83 citation statements)
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“…Although high fructose consumption promoted an increase in glycemia compared with control rats, these values were still in the normality range. Other studies, even with longer periods of high-fructose diet, did not find sharp alterations in glycemia (1,6). In fact, this model characterizes an increase in insulin resistance and not hyperglycemia (1,6).…”
Section: Discussionmentioning
confidence: 80%
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“…Although high fructose consumption promoted an increase in glycemia compared with control rats, these values were still in the normality range. Other studies, even with longer periods of high-fructose diet, did not find sharp alterations in glycemia (1,6). In fact, this model characterizes an increase in insulin resistance and not hyperglycemia (1,6).…”
Section: Discussionmentioning
confidence: 80%
“…High levels of fructose consumption promoted impairment in metabolic parameters and cardiac autonomic control by reduction of vagal tone and an increase in sympathetic modulation with additional insulin resistance after 8 wk of fructose overload in female rats (6). In mice, fructose overload promoted activation in renin-angiotensin system (11).…”
Section: Discussionmentioning
confidence: 98%
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