The aim of this study was in evaluation of twenty-four-hours blood pressure profile parameters in patients with hypertonic encephalopathy and chronic heart failure. 113 patients with hypertonic encephalopathy (39 males, 74 females, mean age 53±13.2 years) were investigated. Chronic heart failure was confirmed in 101 patients (89.4%). There aren’t any essential discrepancies between patients with different stages of hypertonic encephalopathy . Chronic heart failure was associated with elevation of pulse blood pressure more than 53 mm Hg and increase of «non-dipper» and «night-peaker» patients. The same changes of blood pressure profile were related with heart failure progression and intensity of neurological disturbances.