Nociceptive pathways: anatomy and physiology of nociceptive ascending pathways

Wd, Willis

doi:10.1098/rstb.1985.0025

Cited by 66 publications

(18 citation statements)

References 92 publications

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“…The thalamus is a key nociceptive relay, and electrophysiological studies have revealed that neurons in the CM/PF complex respond to nociceptive stimuli (Dong et al, 1978;Willis, 1985). The presence of D2-like receptors in the CM/PF complex offers a mechanism for the reported involvement of dopaminergic systems in the subjective components of pain (Chudler and Dong, 1995;Kamei and Saitoh, 1996).…”

Section: Functional Implicationsmentioning

confidence: 99%

Distribution of Dopamine D2-Like Receptors in the Human Thalamus: Autoradiographic and PET Studies

Rieck

Ansari

Whetsell

et al. 2003

Neuropsychopharmacol

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The distribution of dopamine (DA) D 2 -like receptors in the human thalamus was studied using in vitro autoradiographic techniques and in vivo positron emission tomography in normal control subjects. [ 125 I]Epidepride, which binds with high affinity to DA D 2 and D 3 receptors, was used in autoradiographic studies to determine the distribution and density of D 2 -like receptors, and the epidepride analogue [ 18 F]fallypride positron was used for positron emission tomography studies to delineate D 2 -like receptors in vivo. Both approaches revealed a heterogeneous distribution of thalamic D 2/3 receptors, with relatively high densities in the intralaminar and midline thalamic nuclei, including the paraventricular, parataenial, paracentral, centrolateral, and centromedian/parafascicular nuclei. Moderate densities of D 2/3 sites were seen in the mediodorsal and anterior nuclei, while other thalamic nuclei expressed lower levels of D 2 -like receptors. Most thalamic nuclei that express high densities of D 2 -like receptors project to forebrain DA terminal fields, suggesting that both the thalamic neurons expressing D 2 -like receptors and the projection targets of these neurons are regulated by DA. Because the midline/intralaminar nuclei receive prominent projections from both the ascending reticular activating core and the hypothalamus, these thalamic nuclei may integrate activity conveying both interoceptive and exteroceptive information to telencephalic DA systems involved in reward and cognition.

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Section: Functional Implicationsmentioning

confidence: 99%

Distribution of Dopamine D2-Like Receptors in the Human Thalamus: Autoradiographic and PET Studies

Rieck

Ansari

Whetsell

et al. 2003

Neuropsychopharmacol

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“…It is the major ascending pathway relaying specific information as to the intensity, location, duration, rate, and quality of the noxious stimuli (Willis 1985;Zhang and Giesler 2005). Both Aô and C fibers mainly project in the superficial dorsal horn at lamina I (marginal zone) and lamina II (substantia gelatinosa) (Dubuisson 1989 Besides STT, there are SRT and SMT, which are also involved in pain transmission (Mense 2004).…”

Section: Ll Microglia/macrogliamentioning

confidence: 99%

Axotomy-induced up-regulation of tumor necrosis factor-alpha in the dorsal root ganglia

Miao¹,

Madec²,

Gong³

et al. 2008

Neurological Research

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“…In addition, it is currently believed that the lateral pain system is more involved in sensory-discriminative aspects of pain processing, subserving the ability to analyze location, intensity and duration of the stimulus, whereas the medial system is more responsible for processing the affective-motivational component, giving rise to the unpleasant character of pain perception [3][4][5] . The cognition axis is probably associated with higher brain centers, accounting for attention, anticipation and memory of past experiences.…”

Section: Introductionmentioning

confidence: 99%

Roles of the hippocampal formation in pain information processing

2009

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Abstract:Pain is a complex experience consisting of sensory-discriminative, affective-motivational, and cognitive-evaluative dimensions. Now it has been gradually known that noxious information is processed by a widely-distributed, hierarchicallyinterconnected neural network, referred to as neuromatrix, in the brain. Thus, identifying the multiple neural networks subserving these functional aspects and harnessing this knowledge to manipulate the pain response in new and beneficial ways are challenging tasks. Albeit with elaborate research efforts on the cortical responses to painful stimuli or clinical pain, involvement of the hippocampal formation (HF) in pain is still a matter of controversy. Here, we integrate previous animal and human studies from the viewpoint of HF and pain, sequentially representing anatomical, behavioral, electrophysiological, molecular/ biochemical and functional imaging evidence supporting the role of HF in pain processing. At last, we further expound on the relationship between pain and memory and present some unresolved issues.

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Nociceptive pathways: anatomy and physiology of nociceptive ascending pathways

Cited by 66 publications

References 92 publications

Distribution of Dopamine D2-Like Receptors in the Human Thalamus: Autoradiographic and PET Studies

Distribution of Dopamine D2-Like Receptors in the Human Thalamus: Autoradiographic and PET Studies

Axotomy-induced up-regulation of tumor necrosis factor-alpha in the dorsal root ganglia

Roles of the hippocampal formation in pain information processing

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