“…Nobiletin helps to lower cholesterol levels (Whitman et al, 2005) and some studies indicate that it may improve impaired memory loss (Onozuka et al, 2008) and treat acne (Sato et al, 2007). Nobiletin has been shown to exhibit antitumor activities as indicated by the attenuation of pro-MMP-7 protein and its mRNA expression in HT-29 cells (Kawabata et al, 2005), down-regulation of leptin levels in mice with azoxymethane-and dextran sulfate sodium-induced colon carcinogenesis (Miyamoto et al, 2008), and the suppression of invasion and migration in human gastric adenocarcinoma AGS cells (Lee et al, 2011). Since CXCR4 plays an important role in tumor growth and metastasis, we postulated that nobiletin may modulate the expression of CXCR4 and MMP-9 and suppress tumor cell invasion.…”