Nobel Prize for the Elucidation of Ribosome Structure and Insight into the Translation Mechanism

Nierhaus, Knud H.

doi:10.1002/anie.200905795

Cited by 7 publications

(2 citation statements)

References 24 publications

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“…Differential genes upregulated by E. avium were enriched in the ribosomal and oxidative phosphorylation metabolic pathways. The ribosome is the site of protein synthesis and can read the genetic information contained in the mRNA and convert it into the sequence information of amino acids to synthesize protein [31,32].…”

Section: Discussionmentioning

confidence: 99%

Escherichia coli metabolites promote Enterococcus avium growth by accelerating aerobic metabolic processes

Liu

Hou

Chang

et al. 2022

Preprint

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Background & AimsCooperation between species in the same ecosystem is the core function of microbial communities. We found that in cocultures of Escherichia coli and Enterococcus avium isolated from the gut, the former promoted the growth of the latter. Hence, we investigated the mechanisms by which Escherichia coli promoted the growth of Enterococcus avium.MethodEnterococcus avium was cultured in growth medium supplemented with E. coli metabolites. The physical and chemical properties of the growth-promoting substances were determined by high-performance liquid chromatography. Transcriptomics and metabolomics analyses were performed to determine the possible mechanisms underlying the accelerated growth of Enterococcus avium.ResultsHigher concentrations of Escherichia coli metabolites accelerated the growth of Enterococcus avium in the logarithmic phase but not in the plateau phase. A group of small molecules with high polarity and thermal stability were found to promote the growth of Enterococcus avium. The Escherichia coli metabolites upregulated ribosome expression and oxidative phosphorylation and accelerated several aerobic metabolic processes in Enterococcus avium.ConclusionSome metabolites secreted by Escherichia coli may accelerate aerobic metabolism in Enterococcus avium, thereby increasing its growth rate. This study provides a meaningful insight for understanding the symbiosis between intestinal bacteria and its possible mechanisms.

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Section: Discussionmentioning

confidence: 99%

Escherichia coli metabolites promote Enterococcus avium growth by accelerating aerobic metabolic processes

Liu

Hou

Chang

et al. 2022

Preprint

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“…This explains why its history paralleled the highlights of biological research and has regularly been distinguished by the Nobel Committee. Thus, in 2009 Venki Ramashrisknan, Thomas Steitz, and Ada Yonath shared the Chemistry Nobel Prize for their contribution to the determination of the crystal structure of the ribosome, the macromolecular machine that fabricates proteins (see comments by Carter, 2009;Nierhaus, 2009). Because of this tribute, this essay will highlight data on ribosomes and partners of the protein synthesis machinery that contributed to the development of modern crystallography.…”

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confidence: 99%

Biocrystallography: Past, present, future

Giegé

Sauter

2010

HFSP Journal

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2011: 50 Jahre Entdeckung des genetischen Codes

Erdmann

Barciszewski

2011

Angewandte Chemie

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Professor Alexander Rich gewidmet Genetischer Code · Molekularbiologie · Wissenschaftsgeschichte EinführungIn diesem Jahr feiern wir den 50. Jahrestag der Entdeckung des genetischen Codes, welcher sich als universell für alle Lebewesen auf der Erde herausgestellt hat. 1961 entwarfen Marshall Warren Nirenberg und Johann Heinrich Matthaei ein In-vitro-Translationssystem bestehend aus gereinigten bakteriellen Ribosomen und einer Fraktion niedermolekularer RNA und demonstrierten damit, dass Polyuridylsäure für Polyphenylalanin kodiert. Dies war der Beginn der Erschließung des genetischen Codes. In diesem Essay fassen wir folgende Aspekte zusammen: 1) Ergebnisse, die zur Entdeckung des genetischen Codes geführt haben; 2) Schlüsselexperimente bei der Entdeckung des genetischen Codes; 3) Entwicklungen nach der Entdeckung des genetischen Codes; 4) Schlussfolgerungen, einschließlich der Auswirkungen der Entdeckung des genetischen Codes auf die gegenwärtige Molekularbiologie und Medizin.

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Nobel Prize for the Elucidation of Ribosome Structure and Insight into the Translation Mechanism

Cited by 7 publications

References 24 publications

Escherichia coli metabolites promote Enterococcus avium growth by accelerating aerobic metabolic processes

Escherichia coli metabolites promote Enterococcus avium growth by accelerating aerobic metabolic processes

Biocrystallography: Past, present, future

2011: 50 Jahre Entdeckung des genetischen Codes

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