[no title]

Abstract

I am alsointrigued by theirdecisionto examine the brain stem rather than the forebrain. Vascular stripping of the forebrain does take some little time, but the rate of disappearance of 5-liT from a pre cooled brain in the 3 or 4 minutes needed would not be significant. While Dr. Shaw and his colleagues are cautious (with goodreason) inthediscussion oftheir results, I am unable to accept their implication that a dubious â€oe¿ finding― in the hindbrain tissue may be causally related to limbic lobe function and affective disorder.

Einige biochemische Korrelate einer 48stündigen periodischen Psychose

“…Ähnliche Erhöhung der 5-HIES während der Depression hat R ubin [22] bei zwei Kranken mit rasch wechselnden Phasen festgestellt. Das entspricht auch anderen Arbeiten [7,8,12,23], die bei Depressionen eine Störung von Serotonin und 5-HIES annehmen.…”

Biochemistry of Mental Depression

“…Shaw et al (90) reported low concentrations of 5HT in hindbrain of suicides; Pare et al (64) noted this in the brainstem; and Lloyd et al (48) in certain of the raphe nuclei (the chief sites of synthesis of 5HT in the brain). Bourne et al did not find differences for 5HT, but noted that its chief metabolite 5HIAA was lower in the hindbrains of suicidal patients (10).…”

The Complementary Aspect in the Relation Between Biological and Psychodynamic Psychiatry

“…They can be, but are not necessarily, representative of the situation in the brain. Shaw et al [21] were the first to move the field of investigation to the brain itself. In their recent study they examined brains from depressive patients who had committed suicide.…”