NO synthase 2 ( NOS2 ) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease

Abstract

authors note that in Fig. 2, the ''myosin VI'' labels should be replaced with ''vinculin'' in D and with ''R-Tfn'' in E. The corrected figure and its legend appear below. In addition, the portion of the

Effect of tanshinone on the levels of nitric oxide synthase and acetylcholinesterase in the brain of alzheimer’s disease rat model

“…The inflammatory reaction induced by A in the CNS involves release of damaging factors, such as cytokines, NO and ROS that promote the activation of intracellular pathways, contributing to the progression of AD. [19][20] Our results are in agreement with previous reports. The level of iNOS immunoreactivity and the number of iNOS positive neural cells in the hippocampus of A 1-42 injected rats increased.…”

“…It plays a role in neurotransmission and neuromodulation. 8 However, overproduction of NO appears to be deleterious since it is associated with seizures and brain damage. On the other hand, the expression of NOS during development appears to be important for the final stages of neuronal differentiation.…”

Transduced PEP-1-AMPK inhibits the LPS-induced expression of COX-2 and iNOS in Raw264.7 cells

“…Inducible nitric oxide synthase (iNOS) mediate many physiological events, as it is one of only three enzymes that generates NO. Furthermore, overproduction of iNOS is associated with various human diseases including inflammatory and neuronal disorders (1)(2)(3)(4)(5)(6)(7)(8). Prostaglandins (PGs) are potent proinflammatory mediators, synthesized through arachidonic acid metabolism by cyclooxygenase (COXs), that play an important role in modulating a number of pathophysiological conditions, including inflammatory and allergic immune responses (9).…”

Inhibition of LPS-induced nitric oxide production by transduced Tat-arginine deiminase fusion protein in Raw 264.7 cells

“…Inducible nitric oxide synthase (iNOS) is one of three enzymes generating NO, which mediates many physiological events. It is well known that the overproduction of iNOS is associated with various human diseases including inflammatory and neuronal disorders (13)(14)(15)(16)(17)(18)(19)(20). Lipopolysaccharide (LPS) is the main component of endotoxin and is formed by a phosphoglycolipid that is covalently linked to a hydrophilic heteropolysaccharide (21).…”