No regional difference in cisatracurium dose–response and time-course-of-action between patients in China and Bosnia

Dahaba, Ashraf A.; Suljevic, Ismet; Bornemann, Helmar; Wu, Xiaohong; Metzler, H.

doi:10.1093/bja/aeq369

Cited by 3 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Geographic location and race are known to influence the potency and duration of drug action. Dahaba et al [ 13 ] found a significant difference in rocuronium potency and duration of action among patients in three countries; however, they also showed that there was no difference between Chinese and Caucasians in the comparative dose-response and time-course of cisatracurium activity [ 14 ]. The differences between the EDs in our study and those from existing studies [ 11 12 ] could be based on whether nitrous oxide was used.…”

Section: Discussionmentioning

confidence: 99%

Effective doses of cisatracurium in the adult and the elderly

Kim

Lee

et al. 2016

Korean J Anesthesiol

View full text Add to dashboard Cite

BackgroundThere are few information about the differences of the effective dose (ED) of cisatracurium between the adult and the elderly. We investigated the ED and the onset time of cisatracurium in the adults and the elderly.MethodsWe studied two hundred patients of the adults aged 20 through 64 years and the elderly aged ≥ 65 years, with American Society of Anesthesiologists physical status I or II. Each 100 patients with 20 patients of each dose group, randomly selected from 30, 40, 50, 60 or 70 µg/kg of cisatracurium, were randomly allocated to the adults and the elderly groups. We recorded the 0.1 Hz single twitch responses of the adductor pollicis and the onset times to maximal blockade. The magnitude of muscle relaxation was recorded by using an acceleromyography. The effect of cisatracurium on single twitch was calculated as percent reduction. After converting each drug dose into logarithm and percent reduction of the muscle reduction into probit, the EDs representing the muscle relaxation effects of 5%, 25%, 50%, 75% and 95% were estimated using the linear regression analysis.ResultsNo significant differences were found in age, weight, height, or body mass index within or between the groups. The ED50 and ED95 of the adult group were 35.39 and 59.58 µg/kg. The ED50 and ED95 of the elderly group were 34.89 and 55.50 µg/kg, respectively. The onset times were 375.4 ± 76.9 seconds in the adult group and 369.1 ± 70.0 seconds in the elderly group.ConclusionsThe ED and the onset time were not significantly different between the adult and the elderly.

show abstract

Section: Discussionmentioning

confidence: 99%

Effective doses of cisatracurium in the adult and the elderly

Kim

Lee

et al. 2016

Korean J Anesthesiol

View full text Add to dashboard Cite

show abstract

“…We had to change the infusion dose nearly every 15 min to maintain a constant degree of NMB. If other neuromuscular blocking agents such as rocuronium, atracurium, 7 or cisatracurium 25 were used, the degree of fluctuation might have been different.…”

Section: Discussionmentioning

confidence: 99%

Comparison of motor-evoked potentials monitoring in response to transcranial electrical stimulation in subjects undergoing neurosurgery with partial vs no neuromuscular block

Kim

Lee

et al. 2013

British Journal of Anaesthesia

View full text Add to dashboard Cite

show abstract

“…No differences were found between the white race and the yellow race in the effect of cisatracurium in the doseresponse and time-course-of-action relationships. 32 The autosomal-recessive deficiency of plasma cholinesterase, the enzyme necessary for the degradation of succinylcholine and mivacurium occurs most commonly in the population of white Europeans, while being virtually non-existent in sub-Saharan populations and in the yellow race. 6,33 The deficiency may lead to prolonged apnea after the administration of the agents mentioned above.…”

Section: Neuromuscular Blocking Agentsmentioning

confidence: 99%

The significance of race-related differences in anaesthesiological setting

et al. 2022

View full text Add to dashboard Cite

IntroductionThe human species shows a great variability. The differences involve culture, customs, appearance but they also come to include some biological or physiological aspects which have a potential bearing on the course of diseases and the effects of treatment. Over the recent years, the increasing globalisation and improved travel opportunities have resulted in a growing mass mobility. The arrival of people representing other ethnicities may pose a challenge to doctors traditionally offering treatment to individuals within ethnically homogenous societies.AimThe paper aims to present a comprehensive summary of state-of-the-art knowledge on race-related differences which may be of great importance for patient management in anaesthesiological setting.Material and methodsThis paper is based on the available literature.Results and discussionA literature review reveals a number of anatomical, pharmacokinetic and pharmacodynamic differences between the races. Moreover, particular ethnic groups show dissimilarities in the prevalence of some diseases requiring modifications in anaesthesiological management.ConclusionsPrior to the commencement of treatment, patient’s ethnicity and the consequent differences in terms of physiology should be recognised and considered in the treatment to ensure it is conducted appropriately and safely.

show abstract

No regional difference in cisatracurium dose–response and time-course-of-action between patients in China and Bosnia

Abstract: Cisatracurium dose-response relationship and time-course-of-action were not influenced by geographic location. Thus, cisatracurium would not require dose adjustments between patients living in the two geographic locations.

Cited by 3 publications

References 26 publications

Effective doses of cisatracurium in the adult and the elderly

Effective doses of cisatracurium in the adult and the elderly

Comparison of motor-evoked potentials monitoring in response to transcranial electrical stimulation in subjects undergoing neurosurgery with partial vs no neuromuscular block

The significance of race-related differences in anaesthesiological setting

Contact Info

Product

Resources

About