No Product Design without Process Design (Control)?

Stelzer, Torsten; Ulrich, Joachim

doi:10.1002/ceat.200900478

Cited by 10 publications

(3 citation statements)

References 14 publications

(12 reference statements)

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“…In fact, no product design is possible without process design (control) [33]. Consequently, product and process designs have to be considered together to match the high demands and standards on the desired product qualities [54,55]. This in turn leads to the essential need to possess extensive knowledge of the entire crystallization process.…”

Section: Product Designmentioning

confidence: 99%

Problems, potentials and future of industrial crystallization

Ulrich

Frohberg

2013

Front. Chem. Sci. Eng.

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This review discusses important research developments and arising challenges in the field of industrial crystallization with an emphasis on recent problems. The most relevant areas of research have been identified. These are the prediction of phase diagrams; the prediction of effects of impurities and additives; the design of fluid dynamics; the process control with process analytical technologies (PAT) tools; the polymorph and solvate screening; the stabilization of non-stable phases; and the product design. The potential of industrial crystallization in various areas is outlined and discussed with particular reference to the product quality, process design, and control. On this basis, possible future directions for research and development have been pointed out to highlight the importance of crystallization as an outstanding technique for separation, purification as well as for product design.

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Section: Product Designmentioning

confidence: 99%

Problems, potentials and future of industrial crystallization

Ulrich

Frohberg

2013

Front. Chem. Sci. Eng.

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“…This would lead to the challenge of crystal quality control and reproducibility of cocrystals during mass production due to a more complex mixing pattern in a large scale. As a consequence, a good understanding of the influence of mixing on stoichiometry during cocrystallization in addition to the usual concerns of polymorphism and PSD was necessary for process design, scale-up and product reproducibility …”

Section: Resultsmentioning

confidence: 99%

“…As a consequence, a good understanding of the influence of mixing on stoichiometry during cocrystallization in addition to the usual concerns of polymorphism and PSD was necessary for process design, scale-up and product reproducibility. 37…”

Section: ■ Conclusionmentioning

confidence: 99%

Mixing Effect on Stoichiometric Diversity in Benzoic Acid–Sodium Benzoate Cocrystals

Chen

Yeh

Chen

et al. 2019

Crystal Growth & Design

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The aim of this study was to investigate the mixing effect on the stoichiometric diversity of benzoic acid− sodium benzoate (HBz−NaBz) cocrystals. The crystallization of HBz−NaBz cocrystals in a 500 mL sized glass vessel was monitored under different agitation speeds and feeding rates of HCl aqueous solution. Under good micromixing and macromixing, the HBz crystals, 2:1 and 1:1 cocrystals of HBz−NaBz were crystallized out rapidly, and all crystals were transformed to a mixture of 2:1 and 1:1 cocrystals of HBz− NaBz in a relatively short amount of time. However, the crystallization of 1:1 cocrystals of HBz−NaBz was delayed by poor micro-, meso-, and macromixing simultaneously. The compositions of the products were altered in different mixing conditions even given the identical experiment time. It was feasible to harvest pure 1:1 or pure 2:1 cocrystals of HBz−NaBz by reaction crystallization through the control of the mixing condition, concentration of reactants, and experiment time. The ternary phase diagram was also constructed for the HBz− NaBz−water system.

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Chemical Product Design and Engineering

Costa

Gabriel

Saraiva

et al. 2014

Kirk-Othmer Encyclopedia of Chemical Technology

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Today's chemical industry has goals that range from commodity chemicals to diverse high value added engineered chemical products, such as an exfoliating gel, a disposable nappy or an artificial heart valve. In response to these goals, chemical product engineering has been emerging within chemical engineering. In this chapter, chemical product engineering is described as a body of knowledge structured in terms of three main pillars: the chemical product pyramid; chemical product design and process design integration; and multifaceted multiscale approach. According to this conceptual model, these pillars support chemical product design as the central objective and operational facet of chemical product engineering. A six step template for chemical product design is also presented here. This template starts with the identification of the customer needs a successful product must be able to satisfy, followed by the translation of these needs into objective, quantitative terms. It then proceeds to the generation and selection of alternative product ideas, culminating with the full specification of the product functionality and characteristics. As chemical product engineering increases in importance, it needs systematization and heuristics, just as the well‐established traditional process engineering field has. Chemical products are immensely varied and the conceptual model and template discussed here do not offer a panacea; but they provide a framework within which thinking and practice are possible.

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No Product Design without Process Design (Control)?

Cited by 10 publications

References 14 publications

Problems, potentials and future of industrial crystallization

Problems, potentials and future of industrial crystallization

Mixing Effect on Stoichiometric Diversity in Benzoic Acid–Sodium Benzoate Cocrystals

Chemical Product Design and Engineering

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