No major month to month variation in free testosterone levels in aging males. Minor impact on the biological diagnosis of ‘andropause’

Tancredi, Annalisa; Reginster, Jean‐Yves; Luyckx, Françoise; Legros, Jean-Jacques

doi:10.1016/j.psyneuen.2005.02.002

Cited by 33 publications

(19 citation statements)

References 33 publications

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“…However, the symptoms assessed by ADAM questionnaire are unspecific to hypogonadism and can be multifactorial origin [21]. In addition to the variation of testosterone levels and the sensitivity of AR, chronic illness, stress, poor nutrition, and medication may produce andropausal‐like symptoms and thus confound the diagnosis of late‐onset hypogonadism or andropause [27,30]. Our findings also support this view.…”

Section: Discussionsupporting

confidence: 69%

The Impact of Androgen Receptor CAG Repeat Polymorphism on Andropausal Symptoms in Different Serum Testosterone Levels

Liu

Lee

Wang

et al. 2012

The Journal of Sexual Medicine

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Section: Discussionsupporting

confidence: 69%

The Impact of Androgen Receptor CAG Repeat Polymorphism on Andropausal Symptoms in Different Serum Testosterone Levels

Liu

Lee

Wang

et al. 2012

The Journal of Sexual Medicine

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“…Other studies examining the seasonal variation in T levels have yielded inconsistent results. Tancredi et al (27) reported no major seasonal variation in calculated free T levels among a large sample (nZ5028) of community-dwelling men aged 50-70 years attending a clinic-based andropause assessment. Using data from the Tromsø study, Svartberg et al (28) reported a bimodal seasonal variation in total T levels with a prominent peak in October and November and a nadir in June.…”

Section: Discussionmentioning

confidence: 98%

Association of hypogonadism with vitamin D status: the European Male Ageing Study

Lee

Tajar

Pye

et al. 2012

European Journal of Endocrinology

172

144

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Objective: Interrelationships between hormones of the hypothalamic-pituitary-testicular (HPT) axis, hypogonadism, vitamin D and seasonality remain poorly defined. We investigated whether HPT axis hormones and hypogonadism are associated with serum levels of 25-hydroxyvitamin D (25(OH)D) in men. Design and methods: Cross-sectional survey of 3369 community-dwelling men aged 40-79 years in eight European centres. Testosterone (T), oestradiol (E 2 ) and dihydrotestosterone were measured by gas chromatography-mass spectrometry; LH, FSH, sex hormone binding globulin (SHBG), 25(OH)D and parathyroid hormone by immunoassay. Free T was calculated from total T, SHBG and albumin. Gonadal status was categorised as eugonadal (normal T/LH), secondary (low T, low/normal LH), primary (low T, elevated LH) and compensated (normal T, elevated LH) hypogonadism. Associations of HPT axis hormones with 25(OH)D were examined using linear regression and hypogonadism with vitamin D using multinomial logistic regression. Results: In univariate analyses, free T levels were lower (PZ0.02) and E 2 and LH levels were higher (P!0.05) in men with vitamin D deficiency (25(OH)D !50 nmol/l). 25(OH)D was positively associated with total and free T and negatively with E 2 and LH in age-and centre-adjusted linear regressions. After adjusting for health and lifestyle factors, no significant associations were observed between 25(OH)D and individual hormones of the HPT axis. However, vitamin D deficiency was significantly associated with compensated (relative risk ratio (RRR)Z1.52, PZ0.03) and secondary hypogonadism (RRRZ1.16, PZ0.05). Seasonal variation was only observed for 25(OH)D (P!0.001). Conclusions: Secondary and compensated hypogonadism were associated with vitamin D deficiency and the clinical significance of this relationship warrants further investigation.

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“…More than 30% of men over 70 years have FT concentrations in the hypogonadal range (<4.9 ng/dL). 3–5 …”

Section: Introductionmentioning

confidence: 99%

Longitudinal Changes Over 10 Years in Free Testosterone Among HIV-Infected and HIV-Uninfected Men

Slama

Jacobson

Li³

et al. 2016

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Background Aging in males is associated with lower testosterone levels and a decrease in diurnal variation of testosterone secretion. Cross-sectional studies have shown lower than expected testosterone levels among HIV-infected men, but whether age-related changes in serum testosterone differ by HIV serostatus is not known. Methods HIV-infected men from the Multicenter AIDS Cohort Study (MACS), age ≥ 45 years at highly active antiretroviral therapy initiation, who had ≥ 2 samples from the subsequent 10 years, were matched to HIV-uninfected men by age, race, MACS site, and calendar time of samples. Linear mixed effects regression models were used to determine whether free testosterone (FT) and its rate of change differed by HIV serostatus. Results 182 HIV-infected and 267 HIV-uninfected men were included: median age 48.8 years (Interquartile range (IQR); 45.8, 53.4), median numbers of FT measurements per participant 4 (IQR; 3, 5), 65% were drawn in the AM. Mean adjusted FT levels were lower among HIV-infected than HIV-uninfected men in AM samples (−6.1 ng/dL (95% CI: −9.8, −2.4), p=0.001), but not in PM samples (−1.7 ng/dL (−6.0, 2.6), p=0.441). The rate of FT decline with age did not differ by HIV serostatus: 9.2 ng/dL (95% CI: −13.4, −5.0) per 10 years for HIV- infected vs. 7.9 ng/dL (95% CI: −10.2, −5.5) for HIV-uninfected men, p = 0.578. Conclusion FT decreased similarly with increasing age regardless of HIV serostatus. The lower AM, but not PM, FT levels among HIV-infected men compared to HIV-uninfected men suggests a loss of diurnal variation in FT among HIV-infected men.

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No major month to month variation in free testosterone levels in aging males. Minor impact on the biological diagnosis of ‘andropause’

Cited by 33 publications

References 33 publications

The Impact of Androgen Receptor CAG Repeat Polymorphism on Andropausal Symptoms in Different Serum Testosterone Levels

The Impact of Androgen Receptor CAG Repeat Polymorphism on Andropausal Symptoms in Different Serum Testosterone Levels

Association of hypogonadism with vitamin D status: the European Male Ageing Study

Longitudinal Changes Over 10 Years in Free Testosterone Among HIV-Infected and HIV-Uninfected Men

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