No intrauterine vertical transmission in pregnancy with COVID-19: A case report

Lv, Yantian; Gu, Binbin; Chen, Ying; Hu, Si-Ming; Ruan, Ting; Xu, Guo; Ding, Jian; Xu, Xiao; Shen, Xinghua

doi:10.1016/j.jiac.2020.07.015

Cited by 16 publications

(16 citation statements)

References 10 publications

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“…Of the 70 studies included, 34 were carried out in China [ 5 , 9 , 25 , 26 , 27 , 28 , 30 , 31 , 32 , 42 , 43 , 44 , 45 , 46 , 47 , 53 , 54 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 73 , 78 ], 10 in the United States [ 21 , 22 , 23 , 37 , 48 , 49 , 52 , 75 , 79 , 85 ], eight in Italy [ 24 , 33 , 51 , 55 , 81 , 82 , 83 , 84 ], three in Iran [ 36 ,…”

Section: Resultsmentioning

confidence: 99%

“…A total of 959 newborns were asymptomatic at birth and had negative results for SARS-CoV-2. The distribution of oropharyngeal swab collection time for RT-PCR among studies in which newborns were negative are as follows: At birth ( n = 51) [ 21 , 24 , 31 , 32 , 33 , 34 , 35 , 36 , 38 , 44 , 47 , 48 , 49 , 51 , 54 , 56 , 58 , 61 , 70 , 71 , 73 , 77 , 78 , 80 ], 72 h after birth ( n = 1) [ 70 ], fifth day ( n = 1) [ 69 ], seventh and ninth days ( n = 1) [ 70 ], and fourth to fourteenth days ( n = 1) [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

“…In addition to oropharyngeal swabs, other samples for testing included placental tissue [ 7 , 26 , 27 , 29 , 30 , 32 , 38 , 44 , 47 , 53 , 58 , 59 , 62 , 78 ], fetal membrane [ 27 ], umbilical cord blood [ 5 , 7 , 20 , 29 , 32 , 38 , 44 , 45 , 53 , 58 , 59 , 65 , 78 ], breast milk [ 25 , 29 , 31 , 32 , 35 , 38 , 44 , 45 , 47 , 53 , 57 , 58 , 80 ], amniotic fluid [ 7 , 20 , 25 , 29 , 44 , 45 , 53 , 59 , 62 , 65 , ...…”

Section: Resultsmentioning

confidence: 99%

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Maternal Coronavirus Infections and Neonates Born to Mothers with SARS-CoV-2: A Systematic Review

et al. 2020

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The coronavirus disease 2019 (COVID-19) pandemic is continuously affecting the lives of all people. Understanding the impact of COVID-19 on pregnancy in terms of morbidity, mortality, and perinatal maternal and fetal outcomes is essential to propose strategies for prevention and infection control. Here, we conducted a systematic review to investigate pregnant women infected with COVID-19 in terms of signs and symptoms, type of delivery, comorbidities, maternal and neonatal outcomes, and the possibility of vertical transmission. A search on Embase and PubMed databases was performed on 31 October 2020. Observational studies and case reports on pregnant women infected with COVID-19 were included without language restrictions. The 70 selected studies included a total of 1457 pregnant women diagnosed with COVID-19 in the first, second, and third trimesters of pregnancy. The most common signs and symptoms were fever, cough, and nausea. The most frequent comorbidities were obesity, hypertensive disorders, and gestational diabetes. Among maternal and fetal outcomes, premature birth (n = 64), maternal death (n = 15), intrauterine fetal death or neonatal death (n = 16), cases of intrauterine fetal distress (n = 28), miscarriage (n = 7), decreased fetal movements (n = 19), and severe neonatal asphyxia (n = 5) were the most frequent. Thirty-nine newborns tested positive for SARS-CoV-2. Additionally, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was detected in the placenta (n = 13) and breast milk (n = 6). This review indicates that COVID-19 during pregnancy can result in maternal, fetal, and neonatal complications. In addition, SARS-CoV-2 viral exposure of neonates during pregnancy and delivery cannot be ruled out. Thus, we highlight the need for long-term follow-up of newborns from mothers diagnosed with COVID-19 to establish the full implications of SARS-CoV-2 infection in these children.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Maternal Coronavirus Infections and Neonates Born to Mothers with SARS-CoV-2: A Systematic Review

et al. 2020

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“…This suggested that infants born under 34 weeks may have increased fetal exposure due to lack of surfactants. In the second study, no vertical transmission was detected in the third trimester 9 . The other, in a study conducted in Pope Giovanni 13 Hospital, Bergamo, Italy, one of the babies born from SARS‐CoV‐2 RT–PCR positive mothers was delivered by one normal and the other by cesarean delivery.…”

Section: Discussionmentioning

confidence: 85%

“…In the second study, no vertical transmission was detected in the third trimester. 9 The other, in a study conducted in Pope Giovanni 13 Hospital, Bergamo, Italy, one of the babies born from SARS-CoV-2 RT-PCR positive mothers was delivered by one normal and the other by cesarean delivery. It was reported that swabs taken from newborns were negative, but nasopharyngeal swab results obtained after 7 days from both babies were positive.…”

Section: Discussionmentioning

confidence: 99%

COVID‐19 in third trimester may not be as scary as you think, it can be innocent: Evaluating vertical transmission from a COVID‐19 positive asymptomatic pregnant woman with early membrane rupture

Palalıoğlu

Mahammadaliyeva

Erbıyık

et al. 2020

J of Obstet and Gynaecol

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In the literature, many cases of coronavirus disease 2019 (COVID-19) positive pregnancies have been observed, mostly with mild findings, but there is limited evidence about perinatal transition and early COVID-19 positive newborns. In this case, severe acute respiratory syndrome coronavirus 2 reverse transcription-polymerase chain reaction results were studied from samples obtained from the placenta, amniotic fluid, cord blood and postoperative breast milkthat were obtained while avoiding contamination and preserved appropriatelyof a cesarean section performed under anesthesia on a woman with previous cesarean section and gestational diabetes mellitus history. This patient who presented to our emergency gynecology clinic with membrane rupture was infected with severe acute respiratory syndrome coronavirus 2 two weeks before delivery but was not treated as the disease was asymptomatic. In addition, literature data in line with this topic were evaluated to demonstrate that there was generally no perinatal transmission over 34 weeks of gestation.

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Probable viremia and positive placental swabs for SARS‐CoV‐2 in a preterm pregnant woman with mild COVID‐19

Akdemir

Hacıseyitoğlu

Çelebi

et al. 2021

Journal of Medical Virology

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This study aimed to report a case of mild novel coronavirus disease (COVID‐19) in a pregnant woman with probable viremia, as reverse transcription‐polymerase chain reaction (RT‐PCR) testing of endometrial and placental swabs for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) was positive. A 26‐year‐old multigravida at 35 weeks 2 days of gestation, who had extensive thigh and abdominal cellulitis, tested SARS‐CoV‐2 positive by RT‐PCR performed on samples from the endometrium and maternal side of the placenta. However, other samples (amniotic fluid, fetal side of the placenta, umbilical cord, maternal vagina, and neonatal nasopharynx) tested negative for SARS‐CoV‐2. This is one of the rare reports of probable SARS‐CoV‐2 viremia with the presence of SARS‐CoV‐2 in the endometrium and placenta, but not leading to vertical transmission and neonatal infection. Because knowledge about transplacental transmission and results is very limited, we conclude that more RT‐PCR tests on placental and cord blood samples are needed in order to safely make definite conclusions.

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No intrauterine vertical transmission in pregnancy with COVID-19: A case report

Cited by 16 publications

References 10 publications

Maternal Coronavirus Infections and Neonates Born to Mothers with SARS-CoV-2: A Systematic Review

Maternal Coronavirus Infections and Neonates Born to Mothers with SARS-CoV-2: A Systematic Review

COVID‐19 in third trimester may not be as scary as you think, it can be innocent: Evaluating vertical transmission from a COVID‐19 positive asymptomatic pregnant woman with early membrane rupture

Probable viremia and positive placental swabs for SARS‐CoV‐2 in a preterm pregnant woman with mild COVID‐19

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