NO inhibitors function as potential anti-neuroinflammatory agents for AD from the flowers of Inula japonica

Liu, Feng; Dong, Bangjian; Yang, Xueyuan; Yang, Yuling; Zhang, Jie; Jin, Da Qing; Ohizumi, Yasushi; Lee, Dong‐Ho; Xu, Jing; Guo, Yuanqiang

doi:10.1016/j.bioorg.2018.01.009

Cited by 35 publications

(12 citation statements)

References 39 publications

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“…In fact, excessive amount of NO accumulates in the central nervous system (CNS) as a result of inflammatory response over damaged microglia cells, which in turns exacerbates neuroinflammation and aggravates neurodegenerative diseases [89]. Liu et al [90] isolated various compounds from Inula japonica , in an attempt to find potentially useful compounds with NO inhibitory effects for the treatment of neuroinflammation. Inujaponin F ( 16 ) (Figure 3) and 1-oxo-4αH-eudesma-5(6),11(13)-dien-12,8β-olide ( 17 ) (Figure 3) presented higher NO inhibitory activity in LPS-induced murine microglial BV-2 cells with IC 50 values of 1.3 ± 0.1 μM and 1.5 ± 0.2 μM, respectively, higher activity than the one reported by the positive control 2-methyl-2-thiopseudourea sulphate (SMT) that presented an IC 50 value of 2.9 ± 0.5 μM [90].…”

Section: Secondary Metabolites From Inula Species Against Oxidativmentioning

confidence: 99%

“…Liu et al [90] isolated various compounds from Inula japonica , in an attempt to find potentially useful compounds with NO inhibitory effects for the treatment of neuroinflammation. Inujaponin F ( 16 ) (Figure 3) and 1-oxo-4αH-eudesma-5(6),11(13)-dien-12,8β-olide ( 17 ) (Figure 3) presented higher NO inhibitory activity in LPS-induced murine microglial BV-2 cells with IC 50 values of 1.3 ± 0.1 μM and 1.5 ± 0.2 μM, respectively, higher activity than the one reported by the positive control 2-methyl-2-thiopseudourea sulphate (SMT) that presented an IC 50 value of 2.9 ± 0.5 μM [90]. This anti-neuroinflammatory effect of compounds 16 and 17 , according to the molecular docking studies, could be due to their ability to interact with residues of the active cavities of iNOS protein, blocking it [90].…”

Section: Secondary Metabolites From Inula Species Against Oxidativmentioning

confidence: 99%

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Inula L. Secondary Metabolites against Oxidative Stress-Related Human Diseases

Tavares

Seca

2019

Antioxidants

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An imbalance in the production of reactive oxygen species in the body can cause an increase of oxidative stress that leads to oxidative damage to cells and tissues, which culminates in the development or aggravation of some chronic diseases, such as inflammation, diabetes mellitus, cancer, cardiovascular disease, and obesity. Secondary metabolites from Inula species can play an important role in the prevention and treatment of the oxidative stress-related diseases mentioned above. The databases Scopus, PubMed, and Web of Science and the combining terms Inula, antioxidant and secondary metabolites were used in the research for this review. More than 120 articles are reviewed, highlighting the most active compounds with special emphasis on the elucidation of their antioxidative-stress mechanism of action, which increases the knowledge about their potential in the fight against inflammation, cancer, neurodegeneration, and diabetes. Alantolactone is the most polyvalent compound, reporting interesting EC50 values for several bioactivities, while 1-O-acetylbritannilactone can be pointed out as a promising lead compound for the development of analogues with interesting properties. The Inula genus is a good bet as source of structurally diverse compounds with antioxidant activity that can act via different mechanisms to fight several oxidative stress-related human diseases, being useful for development of new drugs.

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Section: Secondary Metabolites From Inula Species Against Oxidativmentioning

confidence: 99%

Section: Secondary Metabolites From Inula Species Against Oxidativmentioning

confidence: 99%

Inula L. Secondary Metabolites against Oxidative Stress-Related Human Diseases

Tavares

Seca

2019

Antioxidants

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“…More and more research evidence shows that the development of AD is closely related to neuroinflammation [ 55 ]. In the early stage of AD, Aβ activates microglia by promoting the expression of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), IL-1β and IL-6 and then results in a neuroinflammatory environment to induce astrocyte activation and neuronal damage [ 56 ].…”

Section: Pathological Hypothesis Of Alzheimer’s Diseasementioning

confidence: 99%

Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer’s Disease

Deng

Yan

et al. 2023

Molecules

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Alzheimer’s disease (AD) is an age-related chronic progressive neurodegenerative disease, which is the main cause of dementia in the elderly. Much evidence shows that the onset and late symptoms of AD are caused by multiple factors. Among them, aging is the main factor in the pathogenesis of AD, and the most important risk factor for AD is neuroinflammation. So far, there is no cure for AD, but the relationship between neuroinflammation and AD may provide a new strategy for the treatment of AD. We herein discussed the main etiology hypothesis of AD and the role of neuroinflammation in AD, as well as anti-inflammatory natural products with the potential to prevent and alleviate AD symptoms, including alkaloids, steroids, terpenoids, flavonoids and polyphenols, which are available with great potential for the development of anti-AD drugs.

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“…Plant bioactive compounds like curcumin, resveratrol, and piperine play a significant role in antineuroinflammation and neuroprotection activity; they thereby can prevent various neuroinflammatory diseases including Parkinson's, Alzheimer's, and other brain diseases. [177][178][179][180][181][182][183] However, the delivery of those bioactive compounds is playing a key role in the prevention of the above neuroinflammatory diseases. Novel nanodelivery systems like SLNs, nanoemulsions, and nanoliposomes are successful in the delivery of various plant-based bioactive compounds in the treatment of neuroinflammatory diseases.…”

Section: Antineuroinflammation Effectmentioning

confidence: 99%

Microfluidization trends in the development of nanodelivery systems and applications in chronic disease treatments

Ganesan

Karthivashan

Park

et al. 2018

IJN

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Plant bioactive compounds are known for their extensive health benefits and therefore have been used for generations in traditional and modern medicine to improve the health of humans. Processing and storage instabilities of the plant bioactive compounds, however, limit their bioavailability and bioaccessibility and thus lead researchers in search of novel encapsulation systems with enhanced stability, bioavailability, and bioaccessibility of encapsulated plant bioactive compounds. Recently many varieties of encapsulation methods have been used; among them, microfluidization has emerged as a novel method used for the development of delivery systems including solid lipid nanocarriers, nanoemulsions, liposomes, and so on with enhanced stability and bioavailability of encapsulated plant bioactive compounds. Therefore, the nanodelivery systems developed using microfluidization techniques have received much attention from the medical industry for their ability to facilitate controlled delivery with enhanced health benefits in the treatment of various chronic diseases. Many researchers have focused on plant bioactive compound-based delivery systems using microfluidization to enhance the bioavailability and bioaccessibility of encapsulated bioactive compounds in the treatment of various chronic diseases. This review focuses on various nanodelivery systems developed using microfluidization techniques and applications in various chronic disease treatments.

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NO inhibitors function as potential anti-neuroinflammatory agents for AD from the flowers of Inula japonica

Cited by 35 publications

References 39 publications

Inula L. Secondary Metabolites against Oxidative Stress-Related Human Diseases

Inula L. Secondary Metabolites against Oxidative Stress-Related Human Diseases

Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer’s Disease

Microfluidization trends in the development of nanodelivery systems and applications in chronic disease treatments

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