No Indication of Postnatal Selection at the HL‐A Loci*

Bender, Klaus; Mayerová, A; Klotzbücher, B.; Burckhardt, K.; Hiller, Ch.

doi:10.1111/j.1399-0039.1976.tb01040.x

Cited by 20 publications

(4 citation statements)

References 7 publications

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“…The younger blood donor group differed significantly from Alzheimer patients and their controls of the same age in the frequency of HLA-Cwl type. This is not in accordance with the observations of Bender et al (1976) and Hansen e t al. (1977) and leads us t o suggest that, obviously, tissue typing of patients with Alzheimer's disease is relevant only when the control group is of the same age.…”

Section: Discussioncontrasting

confidence: 98%

HLA Antigens in Alzheimer's Disease

et al. 1980

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The histocompatibility antigens of the A, B, and C loci were typed for 32 patients with Alzheimer's disease and 35 controls of the same age. The results were also compared to the distribution of HLA antigens in a series of 900 healthy blood donors. No statistically significant differences were found between the Alzheimer patients and the controls. HLA–Cw1 was found significantly less frequently in the group comprising the patients with Alzheimer's disease and their controls together, than in the younger blood donor group. This leads us to suggest that an age‐matched control group may be needed, at least when the patients are elderly.

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Section: Discussioncontrasting

confidence: 98%

HLA Antigens in Alzheimer's Disease

et al. 1980

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“…We are not able to confirm this: 62.6% of the 382 children had four recognizable HLA antigens, compared with 54.2% among the older persons. This difference is not significant and our results are again in agreement with those of Albert et al (1974) and Bender et al (1976) who did not find more haplotype heterozygotes among old persons.…”

Section: Discussionsupporting

confidence: 94%

“…The only noticeable difference was a slight increase in the frequency of HLA-A1 among the two groups of older persons, compared with that of children. Therefore, our results are in agreement with those of Bender et al (1976). Gerkins et al (1974) also found a higher frequency of HLA-A1 in older than in younger persons.…”

Section: Discussionsupporting

confidence: 93%

An Examination of HLA Frequencies in Three Age Groups

Hansen¹,

Spärck²,

Larsen³

1977

Tissue Antigens

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The question as to whether the distribution of HLA antigens differs between old and young persons has been studied only in a few population groups. There are observations showing an increase of heterozygosity of the HLA system (Bender et al. 1973, Gerkins et al. 1974) which indicate an advantage of heterozygosity for survival, but other studies fail to confirm this finding (Albert et al. 1974, Mucurová et al. 1975, Bender et al. 1976). Since the present authors, in a study of HLA gene frequencies on five small Danish islands (Hansen et al. 1974) had found a tendency to a changed frequency of certain HLA types among the oldest persons, it was decided to examine this question by typing larger numbers of persons of different age groups.

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“…Associations of H L A with disease, as well as indications of a role of the major histocompatibility complex in longevity in mice (Doherty & Zinkernagel 1975, Smith & Walford 1977, suggest some relation of HLA to longevity in humans. There have been reports of possible relationships between age and specific antigens (Macurova et al 1975, Greenberg & Yunis 1978 as well as degree of heterozygosity at the B locus or the number of distinct alleles at the A and B loci (Gerkins et al 1974, Macurova et al 1975, Converse & Williams 1978, Yasuda et al 1980, Hodge & Walford 1980, although different results have been obtained in other studies (Bender et al 1976, Hansen et al 1977, Yarnell et al 1979. We report herein o n a study of such associations in a sample from the population-based Frarningham Study.…”

mentioning

confidence: 63%

Lack of association between HLA and age in an aging population

et al. 1982

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In a sample of 228 Framingham Study participants aged 58 to 86 who were typed for HLA, neither frequencics of individual antigens nor heterozygosity at the A or B loci appeared to be related to age. Previously found associations could be chance occurrences, o r HLA-related effects on longevity in thc general population might be small. It is also possible that such effects occur at younger ages than those included in our study or that HLA is related to the aging process in a way that is detectable only at very advanced agcs.

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No Indication of Postnatal Selection at the HL‐A Loci*

Cited by 20 publications

References 7 publications

HLA Antigens in Alzheimer's Disease

HLA Antigens in Alzheimer's Disease

An Examination of HLA Frequencies in Three Age Groups

Lack of association between HLA and age in an aging population

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