Lack of association between HLA and age in an aging population

Abstract

In a sample of 228 Framingham Study participants aged 58 to 86 who were typed for HLA, neither frequencics of individual antigens nor heterozygosity at the A or B loci appeared to be related to age. Previously found associations could be chance occurrences, o r HLA-related effects on longevity in thc general population might be small. It is also possible that such effects occur at younger ages than those included in our study or that HLA is related to the aging process in a way that is detectable only at very advanced agcs.

HLA‐A, B and DR in Caucasians with transitional cell carcinoma of the bladder

“…Caucasian controls were either healthy residents of Texas (N = 100) or North America (N = 1029 for HLA-A, B; N = 1145 for DR), the latter of which were reported in the Eighth International Histocompatibility Workshop (Baur & Danilovs 1980). Control groups were not agematched with patients since neither frequency (Hansen et al 1977, Blackwelder et al 1982 nor heterozygosity (Blackwelder et al 1982) of HLA antigens was found to vary with age. Local controls and patients were typed for HLA-A, B or DR antigens as described previously (Chauvenet et al 198l), using the Amos Modified Method (Amos et al 1969).…”