No Geographic Correlation between Lyme Disease and Death Due to 4 Neurodegenerative Disorders, United States, 2001–2010

Forrester, Joseph D.; Kugeler, Kiersten J.; Perea, Anna; Pastula, Daniel M.; Mead, Paul S.

doi:10.3201/eid2111.150778

Cited by 28 publications

(9 citation statements)

References 21 publications

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“…[3], [11], [12], hampered by selection bias [11] or with no adequate comparison cohort [11], [14]. Despite the long-term follow-up in our large cohort of LNB patients, we were not able to demonstrate any increased risk of dementia, Alzheimer's disease, Parkinson's disease and motor neuron disease, which is consistent with a geoepidemiology study from the US in which there was no association between the geographical distribution of Lyme disease and the geographical distribution of these neurological disorders [16]. In fact, LNB patients might be subject to detection bias inferred by the diagnostic work-up during and after diagnosis thus increasing the likelihood of diagnosing subclinical dementia, Alzheimer's disease, Parkinson's disease and motor neuron disease [17].…”

Section: Discussion Of Our Own Results and Comparison With Other Studiessupporting

confidence: 49%

Risk of Neurological Disorders in Patients With European Lyme Neuroborreliosis: A Nationwide, Population-Based Cohort Study

Haahr

Tetens

Dessau

et al. 2019

Clinical Infectious Diseases

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Background Lyme neuroborreliosis (LNB), caused by the tick-borne spirochetes of the Borrelia burgdorferi sensu lato species complex, has been suggested to be associated with a range of neurological disorders. In a nationwide, population-based cohort study, we examined the associations between LNB and dementia, Alzheimer’s disease, Parkinson’s disease, motor neuron disease, epilepsy, and Guillain-Barré syndrome. Methods We used national registers to identify all Danish residents diagnosed during 1986–2016 with LNB (n = 2067), created a gender- and age-matched comparison cohort from the general population (n = 20 670), and calculated risk estimates and hazard ratios. Results We observed no long-term increased risks of dementia, Alzheimer’s disease, Parkinson’s disease, motor neuron diseases, or epilepsy. However, within the first year, 8 (0.4%) of the LNB patients developed epilepsy, compared with 20 (0.1%) of the comparison cohort (difference, 0.3%; 95% confidence interval, .02–.6%). In the LNB group, 11 (0.5%) patients were diagnosed with Guillain-Barré syndrome within the first year after LNB diagnosis, compared with 0 (0.0%) in the comparison cohort. After the first year, the risk of Guillain-Barré was not increased. Conclusions LNB patients did not have increased long-term risks of dementia, Alzheimer’s disease, Parkinson’s disease, motor neuron diseases, epilepsy, or Guillain-Barré. Although the absolute risk is low, LNB patients might have an increased short-term risk of epilepsy and Guillain-Barré syndrome.

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Section: Discussion Of Our Own Results and Comparison With Other Studiessupporting

confidence: 49%

Risk of Neurological Disorders in Patients With European Lyme Neuroborreliosis: A Nationwide, Population-Based Cohort Study

Haahr

Tetens

Dessau

et al. 2019

Clinical Infectious Diseases

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“…In fact, the prevalence rate of 4.1% in patients with ALS is similar to the seroprevalence in the normal population of The Netherlands [15]. This is the first casecontrol study to examine the hypothesized link between B. burgdorferi antibodies and ALS, but previous studies with different designs found, as in the present study, a lack of association between Lyme-related antibodies and ALS [1][2][3]16]. In this study we took advantage of the availability of a large set of healthy controls from an ongoing population-based study aimed at identifying environmental, lifestyle and genetic risk factors for ALS.…”

Section: Discussionsupporting

confidence: 74%

No association between Borrelia burgdorferi antibodies and amyotrophic lateral sclerosis in a case–control study

Visser¹,

Lunel

Veldink³

et al. 2016

Euro J of Neurology

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“…Another study found no geographical correlation between LD and death due to Alzheimer’s disease [ 147 ]. A similar debate occurred over 100 years ago regarding the cause of general paresis which was proven when Noguchi and Moore demonstrated Treponema pallidum in brain autopsies of general paresis patients [ 148 ]. The many similarities between syphilis and LB are noted, brain autopsy studies with direct detection methods are the best approach to research this issue is with autopsy studies with direct detection methods which have demonstrated an association between LB and dementia [ 22 , 149 , 150 , 151 ].…”

Section: Resultsmentioning

confidence: 94%

Neuropsychiatric Lyme Borreliosis: An Overview with a Focus on a Specialty Psychiatrist’s Clinical Practice

Bransfield

2018

Healthcare

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There is increasing evidence and recognition that Lyme borreliosis (LB) causes mental symptoms. This article draws from databases, search engines and clinical experience to review current information on LB. LB causes immune and metabolic effects that result in a gradually developing spectrum of neuropsychiatric symptoms, usually presenting with significant comorbidity which may include developmental disorders, autism spectrum disorders, schizoaffective disorders, bipolar disorder, depression, anxiety disorders (panic disorder, social anxiety disorder, generalized anxiety disorder, posttraumatic stress disorder, intrusive symptoms), eating disorders, decreased libido, sleep disorders, addiction, opioid addiction, cognitive impairments, dementia, seizure disorders, suicide, violence, anhedonia, depersonalization, dissociative episodes, derealization and other impairments. Screening assessment followed by a thorough history, comprehensive psychiatric clinical exam, review of systems, mental status exam, neurological exam and physical exam relevant to the patient’s complaints and findings with clinical judgment, pattern recognition and knowledgeable interpretation of laboratory findings facilitates diagnosis. Psychotropics and antibiotics may help improve functioning and prevent further disease progression. Awareness of the association between LB and neuropsychiatric impairments and studies of their prevalence in neuropsychiatric conditions can improve understanding of the causes of mental illness and violence and result in more effective prevention, diagnosis and treatment.

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No Geographic Correlation between Lyme Disease and Death Due to 4 Neurodegenerative Disorders, United States, 2001–2010

Abstract: Death rates for these disorders were not associated with incidence of confirmed Lyme disease cases.

Cited by 28 publications

References 21 publications

Risk of Neurological Disorders in Patients With European Lyme Neuroborreliosis: A Nationwide, Population-Based Cohort Study

Risk of Neurological Disorders in Patients With European Lyme Neuroborreliosis: A Nationwide, Population-Based Cohort Study

No association between Borrelia burgdorferi antibodies and amyotrophic lateral sclerosis in a case–control study

Neuropsychiatric Lyme Borreliosis: An Overview with a Focus on a Specialty Psychiatrist’s Clinical Practice

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