No evidence of an association between MMR vaccine and gait disturbance

Miller, Elizabeth; Andrews, Nicholas; Grant, Aileen; Stowe, Julia; Taylor, Brent

doi:10.1136/adc.2003.048165

Cited by 23 publications

(8 citation statements)

References 7 publications

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“…Previous passive surveillance suggested a temporal relationship between MMR and increased ataxia, 37 whereas a more recent self-controlled case series analysis found no association between gait disturbances and MMR. 38 Overall, the Institute of Medicine concluded that the evidence was "insufficient or absent to assess an association between MMR vaccine and ataxia." 14 Although it is theoretically possible that both vaccines offer protection against ataxia, we instead favor the interpretation that this observation is more likely due to chance, outcome misclassification, or other unmeasured confounding.…”

Section: Discussionmentioning

confidence: 99%

Safety of Measles-Containing Vaccines in 1-Year-Old Children

et al. 2015

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BACKGROUND AND OBJECTIVES: All measles-containing vaccines are associated with several types of adverse events, including seizure, fever, and immune thrombocytopenia purpura (ITP). Because the measles-mumps-rubellavaricella (MMRV) vaccine compared with the separate measles-mumps-rubella (MMR) and varicella (MMR + V) vaccine increases a toddler's risk for febrile seizures, we investigated whether MMRV is riskier than MMR + V and whether either vaccine elevates the risk for additional safety outcomes.

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Section: Discussionmentioning

confidence: 99%

Safety of Measles-Containing Vaccines in 1-Year-Old Children

et al. 2015

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“…They also confirm the need to replicate single reports which have suggested a problem when a new therapy is introduced, with robust systems like our active surveillance system, which has been developed to assess possible adverse events following vaccination and has proved capable of providing a rapid, reliable response to possible vaccine scares 3–6 8 9…”

Section: Discussionmentioning

confidence: 54%

No increased risk of relapse after meningococcal C conjugate vaccine in nephrotic syndrome

Taylor

Andrews

Stowe

et al. 2007

Archives of Disease in Childhood

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Objectives: To investigate whether meningococcal C conjugate vaccine (MCCV) caused relapse in children with steroid-responsive nephrotic syndrome. Design: A population-based study was conducted using an active surveillance system, developed to assess adverse events following vaccination, which linked hospital record information on relapses of nephrotic syndrome to community child health population MCCV data. An ecological study looking at hospital admissions for nephrotic syndrome in different age cohorts of children before and after the MCCV introductory campaign was also carried out. Settings: South East England, and England and Wales. Patients: 52 children having 162 relapses of nephrotic syndrome. Also, all hospital admissions of children aged 2-18 years with steroid-responsive nephrotic syndrome in England and Wales between 1995 and 2003, relating admissions to when MCCV was introduced in specific age cohorts. Main outcome measures and analysis method: Self-controlled case series analysis looking for increased risk of relapse following MCCV and changes in admission rates for nephrotic syndrome (incidence ratio) following the introduction of MCCV to different age cohorts of children. Results: There was no increased risk of relapse following MCCV in the self-control case series, where a relative incidence of 0.95 (95% confidence interval (CI) 0.61-1.47) was found in the 6-month postvaccination period, or in the ecological study, which gave an incidence rate ratio of 1.05 (95% CI 0.95 to 1.15) for the quarter when MCCV was introduced and the following two quarters. Conclusions: We found no association between MCCV and nephrotic syndrome, which is therefore not a contraindication to meningococcal vaccination.T here have been a few anecdotal reports implicating immunisation as a trigger for relapse of nephrotic syndrome in childhood.1 In 2003, a specific increased risk for relapse was suggested after administration of meningococcal C conjugate vaccine (MCCV), based on a study of children with steroid-sensitive nephrotic syndrome attending a tertiary children's hospital.2 A relative incidence of 1.84 (95% confidence interval (CI) 1.27 to 2.65) was reported for relapses in the 6-month post-vaccination period compared with 12 months pre-vaccination. While this study raised the possibility of an increased risk, it could not test the hypothesis because the assessed population contained the nine cases whose original relapses, apparently following MCCV administration, were the basis of the possible association. We have now independently tested the hypothesis.Confirmation or refutation of an effect seemed particularly important, as following the Lancet publication, 2 the UK Committee on Safety of Medicines stated: ''In children with steroid-responsive nephrotic syndrome, Meningococcal C vaccination has been shown to be associated with a relapse of the condition within 6 months post-immunisation. The benefit of vaccination should be carefully weighed against the risk of relapse of nephrotic syndrome in any patient with a...

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“…All MMR vaccinations were followed up for 60 days which allowed comparing vaccinated with non-vaccinated children. According to Miller et al: "this study provides no evidence that MMR vaccine causes acute ataxia or other gait disturbance and suggests that the cases originally described by Plesner were chance occurrences, reflecting background incidence" [113].…”

Section: Health Authorities Might Not Take Note Of This Adverse Reactmentioning

confidence: 77%

Wrong About Vaccine Safety: A Review of Andrew Wakefield’s “Callous Disregard”

Harrison¹

2013

TOVACJ

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On February 28, 1998, Dr. Andrew Wakefield published an article in the Lancet on 12 children "with a history of pervasive developmental disorder and intestinal symptoms. Onset of behavioral symptoms was associated, by the parents, with measles, mumps, and rubella vaccination in eight of the 12 children." Though not claiming the MMR vaccine caused the symptoms, adding what parents thought certainly raised the possibility. Statements and articles by Wakefield suggested he believed such a link probable. Vaccination rates plummeted in the UK and outbreaks of vaccine preventable diseases followed. Investigative journalist Brian Deer uncovered dishonest and unethical medical practices by Wakefield, resulting in Wakefield losing his medical license. Rather than appeal the decision, Wakefield wrote a book, "Callous Disregard: Autism and Vaccines-The Truth Behind a Tragedy," wherein he claims loss of his license was a political attempt to silence his criticism of vaccine safety. This paper examines the validity of Wakefield's claims. A careful review of publicly available information makes it clear that Wakefield's claims regarding vaccine safety are wrong. It is hoped that this review will be used by doctors and public health personnel to encourage parents hesitating to have their children vaccinated to question anti-vaccination claims in general, given that many proponents often refer to Wakefield as an authority and display in their own writings and pronouncements similar erroneous claims.

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No evidence of an association between MMR vaccine and gait disturbance

Cited by 23 publications

References 7 publications

Safety of Measles-Containing Vaccines in 1-Year-Old Children

Safety of Measles-Containing Vaccines in 1-Year-Old Children

No increased risk of relapse after meningococcal C conjugate vaccine in nephrotic syndrome

Wrong About Vaccine Safety: A Review of Andrew Wakefield’s “Callous Disregard”

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