No Effect on Tumorigenesis in MG63 Cells Induced by Co-Cultured Mesenchymal Stem Cells

Abstract

Osteosarcoma is a kind of bone tumor with an extremely high malignant degree and often occurs in adolescents. Mesenchymal stem cells are believed to play an important role in the microenvironment of osteosarcoma, but whether they promote or inhibit the development of osteosarcoma is controversial. In this study, the coexpression of mesenchymal stem cells (MSCs) with osteosarcoma cell MG63 was used to explore the effect of MSCs on MG63. We found that co-culture of MSCs with MG63 did not affect the proliferation, invasion, and migration of MG63 cells, nor did it significantly affect the epithelial- and glial-mesenchymal transformation of MG63 cells. Therefore, in this study, we obtained a new concept that MSCs neither promote nor inhibit the occurrence and development of osteosarcoma.

Unraveling breast cancer prognosis: a novel model based on coagulation-related genes

“…The tumor microenvironment (TME), serving as both a driving force and a regulatory factor in cancer development, facilitates tumor proliferation, migration, and treatment resistance ( Gao et al, 2022 ; Shahzad et al, 2022 ; Xing et al, 2022 ). New evidence suggests that there is a close association between the coagulation process and the tumor microenvironment ( Xu et al, 2022 ; Wei et al, 2023 ).…”