No effect of topical tretinoin on lentigo maligna

Rivers, J. K.

doi:10.1001/archderm.127.1.129b

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Cited by 9 publications

(9 citation statements)

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“…Non-surgical treatment options are used in 50% of U.K. patients over the age of 70, these include radiotherapy, retinoids,8 5-FU and azelaic acid. Cryotherapy, once popular, has fallen from favour because of reports of invasive melanoma occurring after cryotherapy ablation 9.…”

Section: Introductionmentioning

confidence: 99%

Observational Study of Topical Imiquimod Immunotherapy in the Treatment of Difficult Lentigo Maligna

Craythorne

Lawrence

2008

Clinical medicine. Oncology

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Section: Introductionmentioning

confidence: 99%

Observational Study of Topical Imiquimod Immunotherapy in the Treatment of Difficult Lentigo Maligna

Craythorne

Lawrence

2008

Clinical medicine. Oncology

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“…5‐Fluorouracil cream has been reported in the treatment of LM, 38 but this showed a 100% recurrence rate and should not be used. Topical tretinoin also did not prove to be effective 39 …”

Section: Discussionmentioning

confidence: 94%

Survey of U.K. current practice in the treatment of lentigo maligna

Newton-Bishop

2001

British Journal of Dermatology

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This survey highlights that a significant proportion of U.K. dermatologists is managing small numbers of LMs each year. On the basis of this current practice and the data in the literature on the recurrence rates for the different modalities, we propose an algorithm for treatment options. The survey, however, showed no consensus between dermatologists regarding surgical margins for excision, which is reflected in the literature; further studies to establish this are required.

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“…As such, topical retinoids may enhance the imiquimod effect, especially in those who fail to mount an inflammatory response to imiquimod alone. Tazarotene most likely increased bioavailability via decreased stratum corneum cohesion but it is possible that the retinoids exert a direct effect as well 23 . We are currently conducting a clinical trial comparing imiquimod alone versus imiquimod plus topical tazarotene for LM to see if there is an additive benefit to combined therapy.…”

Section: Discussionmentioning

confidence: 99%