2007
DOI: 10.1111/j.1524-4725.2007.34031.x
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Treatment of Lentigo Maligna with Imiquimod before Staged Excision

Abstract: Imiquimod appears to be an effective adjunctive treatment for LM but does not qualify as a replacement therapy for surgery.

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Cited by 49 publications
(44 citation statements)
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“…Imiquimod has been widely used off-label in cases of lentigo maligna (LM) and cutaneous metastatic melanoma (Naylor et al , 2003;Cotter et al , 2008;Buettiker et al , 2008;Powell et al , 2009). Additionally, others and we have demonstrated the ability of imiquimod to enhance vaccine-associated protection against melanoma in mice (Ma et al , 2010;Craft et al , 2005;Prins et al , 2006).…”
Section: Discussionmentioning
confidence: 99%
“…Imiquimod has been widely used off-label in cases of lentigo maligna (LM) and cutaneous metastatic melanoma (Naylor et al , 2003;Cotter et al , 2008;Buettiker et al , 2008;Powell et al , 2009). Additionally, others and we have demonstrated the ability of imiquimod to enhance vaccine-associated protection against melanoma in mice (Ma et al , 2010;Craft et al , 2005;Prins et al , 2006).…”
Section: Discussionmentioning
confidence: 99%
“…There are now several reports that have supported the use of Imiquimod in amelanotic lentigo maligna [24], periocular lentigo maligna [25], facial lentigo maligna [26], and even large lentigo malignas prior to staged excision [27]. However given the reports of Imiquimod causing aggressive SCC, or, in our case, an invasive melanoma arising at the site of topical Imiquimod use, we would like to stress the importance of follow-up after Imiquimod use.…”
Section: Discussionmentioning
confidence: 99%
“…Imiquimod has also been used in the treatment of melanoma in situ and metastatic melanoma in patients with confounding morbidities who are not considered candidates for surgery, with extensive disease or disease in areas that are not amenable to surgery1,2,3,4,5.…”
Section: Introductionmentioning
confidence: 99%