No effect of different estrogen receptor ligands on cognition in adult female monkeys

Lacreuse, Agnès; Wilson, Mark; Herndon, James G.

doi:10.1016/j.physbeh.2008.11.018

Cited by 14 publications

(10 citation statements)

References 65 publications

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“…Beginning on day 9 of the luteal phase (mid-late) macaques (n=14) monkeys were randomly assigned to four treatment groups: Control (no treatment, n=4), Antide to induce early onset of luteal regression as previously reported [24] (GnRH antagonist, 3mg/kg/day; n=4), Antide + progestin replacement with R5020 (synthetic progestin, 2.5 mg/day [24], PerkinElmer Inc, n=3), or Antide + estrogen replacement with two specific estrogen receptor (ER) agonists (ER1, propyl-pyrazole-triol, PPT; ER2, diarylpropionitrile, DPN; both 0.15 mg/kg/day, Tocris Bioscience [30], n=3). The CL was collected from anesthetized females on day 12 of the luteal phase, after 3 days of treatment.…”

Section: Collection Following Induced Luteal Regressionmentioning

confidence: 64%

Dynamics of Immune Cell Types Within the Macaque Corpus Luteum During the Menstrual Cycle: Role of Progesterone1

Bishop

Molskness

et al. 2015

Biology of Reproduction

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The goal of the current study was to characterize the immune cell types within the primate corpus luteum (CL). Luteal tissue was collected from rhesus females at discrete intervals during the luteal phase of the natural menstrual cycle. Dispersed cells were incubated with fluorescently labeled antibodies specific for the immune cell surface proteins CD11b (neutrophils and monocytes/macrophages), CD14 (monocytes/macrophages), CD16 (natural killer [NK] cells), CD20 (B-lymphocytes), and CD3epsilon (T-lymphocytes) for analysis by flow cytometry. Numbers of CD11b-positive (CD11b(+)) and CD14(+) cells increased significantly 3 to 4 days after serum progesterone (P4) concentrations declined below 0.3 ng/ml. CD16(+) cells were the most abundant immune cell type in CL during the mid and mid-late luteal phases and were 3-fold increased 3 to 4 days after serum P4 decreased to baseline levels. CD3epsilon(+) cells tended to increase 3 to 4 days after P4 decline. To determine whether immune cells were upregulated by the loss of luteotropic (LH) support or through loss of LH-dependent steroid milieu, monkeys were assigned to 4 groups: control (no treatment), the GnRH antagonist Antide, Antide plus synthetic progestin (R5020), or Antide plus the estrogen receptor agonists diarylpropionitrile (DPN)/propyl-pyrazole-triol (PPT) during the mid-late luteal phase. Antide treatment increased the numbers of CD11b(+) and CD14(+) cells, whereas progestin, but not estrogen, replacement suppressed the numbers of CD11b(+), CD14(+), and CD16(+) cells. Neither Antide nor steroid replacement altered numbers of CD3epsilon(+) cells. These data suggest that increased numbers of innate immune cells in primate CL after P4 synthesis declines play a role in onset of structural regression of primate CL.

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Section: Collection Following Induced Luteal Regressionmentioning

confidence: 64%

Dynamics of Immune Cell Types Within the Macaque Corpus Luteum During the Menstrual Cycle: Role of Progesterone1

Bishop

Molskness

et al. 2015

Biology of Reproduction

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“…The delayed recognition span test (DRST) followed Lacreuse et al (). DRST is a test of simple working memory that is sensitive to hippocampal lesions in monkeys (Beason‐Held et al, ).…”

Section: Methodsmentioning

confidence: 99%

“…We tested 2.5‐ to 3‐year‐old children who would be expected to be in the transitional zone for success on the door task. Children were tested on the door task and four other tasks, a test of spatial working memory (three boxes stationary, Diamond et al, ), a test of nonspatial working memory (three boxes scrambled, Diamond et al, ), a test of inhibitory control (three pegs task, Balamore & Wozniak, ; Diamond et al, ), and a test of working memory that simply entailed maintaining information over a delay (delayed recognition memory span test, Lacreuse, Wilson, & Herndon, ), in order to determine if children's abilities in any of these domains could be associated with performance on the Berthier et al door task. These tests, with the exception of the working memory test that entailed simple maintenance of information, have been associated with the function of prefrontal cortex (Diamond et al, ; Petrides, ).…”

Section: Introductionmentioning

confidence: 99%

Working memory and inhibitory control in visually guided manual search in toddlers

Jenkins

Berthier

2014

Developmental Psychobiology

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Toddlers undergo a transition at about 2.5-3 years-of-age that dramatically improves their ability to search for hidden objects. The development of these skills seems to depend on the development of executive functions. We used a correlational design to investigate which components of executive function might be involved in this improved search. Three tests of working memory did not correlate with search performance, but a test of inhibitory/cognitive control was associated with performance increases. Improvement seemed to be the result of control of visual attention and responding in the face of misleading visual events and not the result of improvements in working memory.

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“…In this case, the difference in the strain of rats used in the two studies (Long Evans versus Sprague Dawley, respectively) may have contributed to the discrepancies, as other conditions were similar. In general, species, age, and duration of treatment may also be important factors, as chronic treatment of either ERα or ERα agonists enhances cognition in young rats (Hammond et al, 2009), impair cognition in middle-aged rats (Neese et al, 2010), and has no cognitive effects in adult monkeys (Lacreuse et al, 2009). These studies underscore the complexity of factors involved in using SERMs and warrant further investigation of potential parameters that impact cognitive outcome.…”

Section: Hormone Receptors and The Cognitive Effects Of Hormonesmentioning

confidence: 99%

An update on the cognitive impact of clinically-used hormone therapies in the female rat: Models, mazes, and mechanisms

et al. 2013

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In women, ovarian hormone loss associated with menopause has been associated with cognitive decline. Hormone therapy (HT) may ameliorate some of these changes. Understanding the cognitive impact of female steroids, including estrogens, progestogens, and androgens, is key to discovering treatments that promote brain health in women. The preclinical literature has presented elegant and methodical experiments allowing a better understanding of parameters driving the cognitive consequences of ovarian hormone loss and HT. Animal models have been a valuable tool in this regard, and will be vital to future discoveries. Here, we provide an update on the literature evaluating the impact of female steroid hormones on cognition, and the putative mechanisms mediating these effects. We focus on preclinical work that was done with an eye toward clinical realities. Parameters that govern the cognitive efficacy of HT, from what we know thus far, include but are not limited to: type, dose, duration, and route of HT, age at HT initiation, timing of HT relative to ovarian hormone loss, memory type examined, menopause history, and hormone receptor status. Researchers have identified intricate relationships between some of these factors by studying their individual effects on cognition. As of late, there is increased focus on studying interactions between these variables as well as multiple hormone types when administered concomitantly. This is key to translating preclinical data to the clinic, wherein women typically have concurrent exposure to endogenous ovarian hormones as well as exogenous combination HTs, which include both estrogens and progestins. Gains in understanding the parameters of HT effects on cognition provide exciting novel avenues that can inform clinical treatments, eventually expanding the window of opportunity to optimally enhance cognition and brain health in aging women.

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No effect of different estrogen receptor ligands on cognition in adult female monkeys

Cited by 14 publications

References 65 publications

Dynamics of Immune Cell Types Within the Macaque Corpus Luteum During the Menstrual Cycle: Role of Progesterone1

Dynamics of Immune Cell Types Within the Macaque Corpus Luteum During the Menstrual Cycle: Role of Progesterone1

Working memory and inhibitory control in visually guided manual search in toddlers

An update on the cognitive impact of clinically-used hormone therapies in the female rat: Models, mazes, and mechanisms

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