Dynamics of Immune Cell Types Within the Macaque Corpus Luteum During the Menstrual Cycle: Role of Progesterone1

Bishop, Cecily V.; Xu, Fan; Molskness, Theodore A.; Stouffer, Richard L.; Hennebold, Jon D.

doi:10.1095/biolreprod.115.132753

Cited by 14 publications

(23 citation statements)

References 68 publications

(90 reference statements)

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“…Since PGF-2treatment of cycling female pigs was shown to increase of macrophage infiltration into the CL [3], one possible explanation for these findings is that macrophages play a role in the acquisition of LS. Macrophages infiltrate the porcine CL throughout the estrous cycle [4] in confirmation of similar observations in other species [5][6][7][8][9][10][11][12]. Specifically in the pig, intra-luteal macrophage numbers increased ~4-fold between days 4-6 and days 7-12 of the estrous cycle [4], which coincides temporally with the development of LS during the normal estrous cycle [13].…”

Section: Introductionsupporting

confidence: 79%

Prostaglandin synthesis by the porcine corpus luteum: effect of tumor necrosis factor-α

Chang

Frandsen

Gadsby

2017

Domestic Animal Endocrinology

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The porcine corpus luteum (CL) displays delayed sensitivity to PGF-2α (luteolytic sensitivity, [LS]) until days 12 to 13 of cycle. The control of LS is unknown, but it is temporally associated with macrophage (which secrete tumor necrosis factor-α; TNF-α) infiltration into the CL. Other studies showed that TNF-α induces LS in vitro and that prostaglandins (PGs) may be involved in this mechanism. In experiment 1, PGF-2α and PGE secretion by luteal cells (LCs) was measured on days 4 to 14 of the estrous cycle, and the expression of PTGFS/AKR1B1 and PTGES/mPGES-1, determined by Western blot, before (day 7) vs after (day 13) the onset of LS. Results showed that the PGF-2α:PGE ratio increased significantly (P < 0.05) from day 4 to 13-14, and PTGFS/AKR1B1 and PTGES/mPGES-1 were significantly increased (P < 0.05) on day 13 (vs day 7). In experiment 2, LCs were collected from porcine CL at early (∼days 4-6) or mid (∼days 7-12) stages of the estrous cycle and cultured with 0, 0.1, 1, or 10 ng/mL TNF-α. Results showed that TNF-α significantly increased (P < 0.05) messenger RNA (mRNA) expression of cyclooxygenase (COX)-2 and mPGES-1 but not AKR1B1. TNF-α had no significant effects on AKR1B1 or mPGES protein abundance. TNF-α significantly increased (P < 0.05) PGE-2 but had no effect on PGF-2α secretion or on the PGF-2α:PGE2 ratio. In conclusion, although TNF-α increased COX2 and mPGES-1 mRNA, and PGE-2 secretion in vitro, it did not increase the PGF-2α:PGE2 ratio. Studies are currently directed toward exploring other pathways (eg, FP receptor signaling) by which TNF-α induces LS in the porcine CL.

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Section: Introductionsupporting

confidence: 79%

Prostaglandin synthesis by the porcine corpus luteum: effect of tumor necrosis factor-α

Chang

Frandsen

Gadsby

2017

Domestic Animal Endocrinology

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“…55,57 These findings strongly suggest that PMN also are found during the same period in the CL of primates. 9 Human PMN produce several cytokines and growth factors including vascular endothelial growth factor A (VEGFA). 58 Furthermore, in the cow, EC are directly activated by PMN to induce the sprouting of capillary-like structures in vitro.…”

Section: Polymorphonuclear Neutrophilsmentioning

confidence: 99%

“…PMN can infiltrate into the developing CL after ovulation, and many PMN are detected in the CL tissue of cows during the early luteal phase . These findings strongly suggest that PMN also are found during the same period in the CL of primates . Human PMN produce several cytokines and growth factors including vascular endothelial growth factor A (VEGFA) .…”

Section: Introductionmentioning

confidence: 99%

“…6 In addition to steroidogenic cells, the CL contains endothelial cells (EC), pericytes, fibroblasts and immune cells. [7][8][9] During the estrous cycle, the CL is developed from the ovulatory follicle and undergoes remarkable growth, differentiation and remodeling. 10 If an oocyte is not fertilized, the CL will regress, with apoptosis of luteal cells and a decline in P4 synthesis.…”

Section: Introduction Corpus Luteummentioning

confidence: 99%

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Inflammation and angiogenesis in the corpus luteum

Wang

et al. 2019

J of Obstet and Gynaecol

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Angiogenesis is a very important process that helps establish and maintain the normal structure and function of the corpus luteum (CL). Early luteal development can be considered a kind of physiological injury with an inflammatory response; therefore, the inflammatory response may play an important role in the luteal angiogenesis. The inflammatory response is companied by activated leukocytes and their mediators. For luteal tissue, numerous activated leukocytes such as macrophages, neutrophils and eosinophils are present in the early luteal phase and are widely involved in neovascularization. The objective of this review is to describe the role of the inflammatory factors in the angiogenesis and to discuss their mechanism. Knowledge of action and mechanism of these inflammatory factors on angiogenic activity will be beneficial for the understanding of luteal function.

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“…Results indicated the mice treated with propanil showed an increase in the percent of CD11b + cells (Figure 9 A) but a decrease in the number of CD11b + cells (Figure 9 B). In a macaque corpus luteum, antide treatment increased the number of CD11b + cells (Bishop et al, 2015).…”

Section: Chapter 4: Resultsmentioning

confidence: 93%

The acute effect of propanil on reproductive hormones, ovarian gene expression and splenic cells in C57Bl/6 female mice

Berg¹

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The acute effect of propanil on reproductive hormones, ovarian gene expression and splenic cells in C57Bl/6 female mice Malia Danielle Berg Earlier evidence indicates exposure to propanil, a post-emergent herbicide used on rice and wheat fields, increases the number of antibody-secreting cells (ASC) in the spleen of mice after immunization with heat-killed Streptococcus pneumoniae (HKSP, 2x10 8 CFU). Interestingly, an intact hypothalamic-pituitary-gonadal (HPG) axis is required for this immune response assessed on day 7-10 after immunization in female mice. Hence, an overarching premise is that propanil arbitrates the connection between the reproductive and immune system by altering the concentration of hormones involved in the HPG axis, which may then affect the populations of splenic cells. Hypotheses were tested with C57Bl/6 female mice vaccinated with HKSP and assigned among four treatment groups (6 mice each) in a 2x2 factorial arrangement. The first factor represented propanil treatment (propanil, control), and the second factor represented two periods (24h, 72h) of collection for blood, spleen, ovaries, and oviducts after immunization. At 24h, propanil decreased the number of splenocytes contrary to increased cell populations at day 7-10 observed in earlier experiments. Also, propanil increased serum concentrations of prolactin and progesterone but decreased estradiol, corroborated by corresponding changes in mRNA for steroid synthesis in ovaries. To determine if these effects depend on gonadotropin-releasing hormone (GnRH) receptor binding, we utilized the GnRH antagonist (antide; 60 µg s.q.), given to C57Bl/6 female mice before the same immunization with HKSP. In ovaries, antide increased gene expression of inflammatory and anti-inflammatory cytokines and markers (Csf1, Cxcl1, Cxcl10, Il-10, Irf-1, Tlr2), interacted with propanil effect in HKSP-challenged mice on the expression of serum amyloid A by reducing propanil's effects. In the spleen, antide decreased the number of T-cells, and in the presence of HKSP decreased the number of B-cells and the percentage of monocytes and macrophages. Thus, GnRH receptors may be necessary for the acute responses (24 hours) to propanil and support a hypothesis that immune and reproductive systems interact in female mice challenged with the bacterial vaccine.

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Dynamics of Immune Cell Types Within the Macaque Corpus Luteum During the Menstrual Cycle: Role of Progesterone1

Cited by 14 publications

References 68 publications

Prostaglandin synthesis by the porcine corpus luteum: effect of tumor necrosis factor-α

Prostaglandin synthesis by the porcine corpus luteum: effect of tumor necrosis factor-α

Inflammation and angiogenesis in the corpus luteum

The acute effect of propanil on reproductive hormones, ovarian gene expression and splenic cells in C57Bl/6 female mice

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