No differences in performance on test of working memory and executive functioning between healthy elderly postmenopausal women using or not using hormone therapy

Grigorova, Miglena; Sherwin, Barbara B.

doi:10.1080/13697130600727107

Cited by 26 publications

(15 citation statements)

References 63 publications

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“…However, estrogen treatment in the perimenopausal period did not enhance memory (LeBlanc et al, 2007). In older post-mensopausal women, some studies show that estrogen use enhances performance on tests of verbal (Kampen and Sherwin, 1994) and visual or spatial memory (Duka et al, 2000;Smith et al, 2001); however, several others do not (File et al, 2002;Grigorova and Sherwin, 2006;Polo-Kantola et al, 1998;Schiff et al, 2005). Finally, there are no other studies to date that examine hormone effects on memory for emotional stimuli, particularly for images in the IAPS.…”

Section: Discussionmentioning

confidence: 92%

Estrogen modifies arousal but not memory for emotional events in older women

Pruis

Neiss

Leigland

et al. 2009

Neurobiology of Aging

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Emotional arousal and the affective content of events influence memory. These effects shift with age such that older people find negative information less arousing and remember proportionately more positive events compared to the young. The emotional enhancement of memory is mediated by medial temporal lobe limbic structures and the prefrontal cortex, which are both affected by sex hormones. We examined whether hormone use (estrogen or estrogen and progesterone) in older women modulated perceptions of valence and arousal, and subsequent memory for emotional images or stories. Their performance was compared to younger women. Hormone use in older women resulted in higher arousal for negative images and stories but memory was not affected. We hypothesize that estrogen modifies the influence of the amygdala and the prefrontal cortex on emotion, but that agerelated changes in the hippocampus prevent the enhancement of emotional memory in older women.

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Section: Discussionmentioning

confidence: 92%

Estrogen modifies arousal but not memory for emotional events in older women

Pruis

Neiss

Leigland

et al. 2009

Neurobiology of Aging

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“…[266] recently provided evidence for executive dysfunction in untreated menopausal women, as women with hormone replacement therapy (HRT) outperformed women without HRT on tests requiring directed attention, inhibition of inappropriate responses, and cognitive set switching. A number of other studies have also provided evidence that estrogen enhances prefrontal cognitive processes such as working memory and attention [267][268][269][270][271][272][273][274], although there are dissenting reports [275]. For instance, a recent study by Joffe et.…”

Section: The Hippocampus and Prefrontal Cortex As Important Sites Of mentioning

confidence: 99%

Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications

et al. 2007

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Estrogen is an important hormone signal that regulates multiple tissues and functions in the body. This review focuses on the neurotrophic and neuroprotective actions of estrogen in the brain, with particular emphasis on estrogen actions in the hippocampus, cerebral cortex and striatum. Sex differences in the risk, onset and severity of neurodegenerative disease such as Alzheimer's disease, Parkinson's disease and stroke are well known, and the potential role of estrogen as a neuroprotective factor is discussed in this context. The review assimilates a complex literature that spans research in humans, non-human primates and rodent animal models and attempts to contrast and compare the findings across species where possible. Current controversies regarding the WHI (Women's Health Initiative) study, its ramifications, concerns and the new studies needed to address these concerns are also addressed. Signaling mechanisms underlying estrogen-induced neuroprotection and synaptic plasticity are reviewed, including the important concepts of genomic versus nongenomic mechanisms, types of estrogen receptor involved and their subcellular targeting, and implicated downstream signaling pathways and mediators. Finally, a multicellular mode of estrogen action in the regulation of neuronal survival and neurotrophism is discussed, as are potential future directions for the field.

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“…Although some studies have reported that treatment with estrogen and progestin improves spatial and verbal memory [10, 25], other studies, including the Women’s Health Initiative (WHI) Memory Study and WHI Study of Cognitive Aging, report little or no benefit of estrogen plus progestin therapy on measures of both global cognitive function and specific memory abilities [23, 33, 34, 40]. These inconsistencies highlight the need to more clearly understand how estrogens and progestins (e.g., progesterone) influence cognitive function.…”

Section: Introductionmentioning

confidence: 99%

Post-training progesterone dose-dependently enhances object, but not spatial, memory consolidation

Harburger

Pechenino

Saadi

et al. 2008

Behavioural Brain Research

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The aim of this study was to determine if progesterone modulates object and spatial memory consolidation in young ovariectomized C57BL/6 mice. Object memory was tested in an object recognition task using 24-and 48-hr delays. Spatial memory was tested in a 2-day version of the Morris water maze in which retention was tested 24 or 48 hrs after training. Immediately after training in each task, mice received a single intraperitoneal injection of vehicle or 5, 10, or 20 mg/kg watersoluble progesterone. Mice were then tested 24 or 48 hrs later in the absence of circulating progesterone. Post-training injections of 10 and 20 mg/kg progesterone enhanced object recognition, but not memory in the spatial water maze. These findings suggest that object memory consolidation in young female mice is more sensitive to the modulatory effects of progesterone than spatial memory consolidation, at least using the tasks, doses, and delays tested. As such, these findings may have important implications for the design of progesterone therapies intended to reduce age-related memory decline.

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No differences in performance on test of working memory and executive functioning between healthy elderly postmenopausal women using or not using hormone therapy

Abstract: There was no relationship between neuropsychological performance, age of initiation of HT, or duration of HT use.

Cited by 26 publications

References 63 publications

Estrogen modifies arousal but not memory for emotional events in older women

Estrogen modifies arousal but not memory for emotional events in older women

Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications

Post-training progesterone dose-dependently enhances object, but not spatial, memory consolidation

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