No detection of parvovirus B19 or herpesvirus DNA in giant cell arteritis

Rodríguez-Pla, Alicia; Bosch‐Gil, Josep Angel; Echevarría-Mayo, Juan Emilio; Rosselló-Urgell, José; Soláns-Laqué, Roser; Huguet-Redecilla, Pere; Stone, John H.; Vilardell‐Tarrés, Miquel

doi:10.1016/j.jcv.2004.05.003

Cited by 53 publications

(30 citation statements)

References 35 publications

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“…Therefore, these results do not confirm associations between these agents and giant cell arteritis. In this respect, they are in agreement with Cankovic and Zarbo [2006], Rodriguez-Pla et al [2004], Helweg-Larsen et al [2002], Haugeberg et al [2000], and Nordborg et al…”

Section: Discussionsupporting

confidence: 86%

Infection and temporal arteritis: A PCR‐based study to detect pathogens in temporal artery biopsy specimens

Cooper¹,

D’Arcy²,

Kirby³

et al. 2008

Journal of Medical Virology

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The possibility of infectious triggers stimulating the development of inflammatory vascular diseases has generated much recent interest. This study uses PCR to detect the presence of Chlamydia pneumoniae, parvovirus B19 and all the human herpes viruses except HHV8 in temporal artery biopsy specimens. Samples from 37 temporal artery biopsies with histological evidence of arteritis and 66 samples from histologically negative temporal artery biopsies, all from different patients, were negative for C. pneumoniae, HSV, VZV, EBV, and HHV7 DNA. Two of the 37 histologically positive specimens were positive for HHV6, another two for CMV and a further two for parvovirus B19 DNA. Parvovirus B19 DNA was also detected in five histologically negative biopsies, one positive for HCMV DNA and a further one was positive for HHV6 DNA. There is no statistically significant difference to the presence of virus DNA in the two types of specimens (P = 0.538). This study does not support a role for C. pneumoniae, parvovirus B19 or human herpes viruses in the pathogenesis of temporal arteritis.

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Section: Discussionsupporting

confidence: 86%

Infection and temporal arteritis: A PCR‐based study to detect pathogens in temporal artery biopsy specimens

Cooper¹,

D’Arcy²,

Kirby³

et al. 2008

Journal of Medical Virology

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“…Also, we did not find an association between GCA incidence and altitude in Lugo (54). In keeping with our results, 4 different recent studies did not confirm any association between the presence of parvovirus B19, C pneumoniae, or human herpesvirus DNA in TAB specimens and the histologic evidence of biopsy-proven GCA (55)(56)(57)(58).…”

Section: Etiologysupporting

confidence: 87%

Epidemiology of giant cell arteritis and polymyalgia rheumatica

González-Gay¹,

Vázquez-Rodríguez²,

Lopez-Diaz³

et al. 2009

Arthritis & Rheumatism

496

286

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“…All 46 patients with positive TABs whose clinical records were available for review met the ACR classification criteria for GCA. 13 The principal clinical features of patients with positive and negative TABs, reported previously, 16 are summarized in Table 1.…”

Section: Clinical Datamentioning

confidence: 99%

Metalloproteinase-2 and -9 in Giant Cell Arteritis

et al. 2005

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Background-Both matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) have been postulated to play roles in the pathophysiology of giant cell arteritis (GCA) because of their ability to degrade elastin. Understanding the specific mediators of arterial damage in GCA could lead to new therapeutic targets in this disease. Methods and Results-Temporal artery biopsy specimens were obtained from 147 consecutive patients suspected of GCA. Clinical and histopathological data were collected according to protocol. Using immunohistochemistry, we compared the expression of MMP-2 and MMP-9 in the temporal artery biopsies of both GCA cases (nϭ50) and controls (nϭ97). MMP-9 was found more frequently in positive than in negative temporal artery biopsies (adjusted odds ratio [OR], 3.20; Pϭ0.01). In contrast, the frequency of MMP-2 was not significantly different between positive and negative biopsies (adjusted OR, 2.18; Pϭ0.22). Both MMP-2 and MMP-9 were found in macrophages and giant cells near the internal elastic lamina and in smooth muscle cells and myofibroblasts of the media and intima. MMP-9 was also found in the vasa vasorum. MMP-9 but not MMP-2 was associated with internal elastic lamina degeneration, intimal hyperplasia, and luminal narrowing, even after adjustment for possible confounding variables. Conclusions-MMP-9 appears more likely than MMP-2 to be involved in the pathophysiology of GCA. MMP-9 not only participates in the degradation of elastic tissue but also is associated with intimal hyperplasia, subsequent luminal narrowing, and neoangiogenesis.

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No detection of parvovirus B19 or herpesvirus DNA in giant cell arteritis

Cited by 53 publications

References 35 publications

Infection and temporal arteritis: A PCR‐based study to detect pathogens in temporal artery biopsy specimens

Infection and temporal arteritis: A PCR‐based study to detect pathogens in temporal artery biopsy specimens

Epidemiology of giant cell arteritis and polymyalgia rheumatica

Metalloproteinase-2 and -9 in Giant Cell Arteritis

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