Epidemiology of giant cell arteritis and polymyalgia rheumatica

González-Gay, Miguel Á.; Vázquez-Rodríguez, Tomás R.; Lopez-Diaz, Maria J.; Miranda‐Filloy, José A.; González‐Juanatey, Carlos; Martín, Javier; Llorca, Javier

doi:10.1002/art.24459

Cited by 496 publications

(340 citation statements)

References 67 publications

(107 reference statements)

Supporting

Mentioning

286

Contrasting

Unclassified

Order By: Relevance

“…Giant cell arteritis (GCA) is the most frequent form of vasculitis in adults (1,2). Incidence is generally higher in Northern regions (1).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Incidence of infections in patients with giant cell arteritis: A cohort study

Durand¹,

Thomas²

2012

Arthritis Care & Research

View full text Add to dashboard Cite

Objective. Giant cell arteritis (GCA) is the most frequent form of vasculitis in adults. We sought to estimate the infectious risk associated with GCA and its treatment. Methods. We conducted a matched historical cohort study using data from The Health Improvement Research Network. Patients with newly diagnosed GCA were matched with up to 6 non-GCA patients by age, sex, general practice, and date of entry into the cohort. Random-effects Poisson regression models were used to obtain incidence rates and rate ratios for lower respiratory tract infections (LRTI), urinary tract infections (UTI), and sepsis, as well as for the subset of these that comprised serious infections (pneumonias, upper UTI, and sepsis). Effect modification by age, sex, and time since diagnosis of GCA was assessed. Results. A total of 1,664 patients with GCA were matched to 8,078 patients without GCA. Overall, 805 (48%) of the GCA patients and 3,007 (37%) of the non-GCA patients experienced >1 episode of systemic infection during followup, with adjusted rate ratios for LRTI, UTI, and serious infections of 1.48 (95% confidence interval [95% CI] 1.34 -1.65), 1.27 (95% CI 1.10 -1.46), and 1.55 (95% CI 1.22-1.96), respectively (P < 0.001 for all). The rate ratio for sepsis was 1.63 (95% CI 0.78 -3.40, P ‫؍‬ 0.20). Rate ratios for infection were highest in the first 6 months following diagnosis of GCA and in patients age <75 years, but did not vary by sex. Conclusion. This is the first study to show that patients with GCA are at increased risk of systemic infections, particularly in the first few months following diagnosis. New GCA medications that allow steroid sparing are needed to treat this condition.

show abstract

“…Giant cell arteritis (GCA) is the most frequent form of vasculitis in adults (1,2). Incidence is generally higher in Northern regions (1).…”

Section: Introductionmentioning

confidence: 99%

“…Incidence is generally higher in Northern regions (1). Reports of incidence (in cases per million person-years in population age Ͼ50 years) vary widely; for example, 328 in Norway (3), 101 in NorthWestern Spain (1), in Germany (4), 11 in Turkey (5), and 3.4 in Hong Kong (6).…”

Section: Introductionmentioning

confidence: 99%

Incidence of infections in patients with giant cell arteritis: A cohort study

Durand¹,

Thomas²

2012

Arthritis Care & Research

View full text Add to dashboard Cite

show abstract

“…Minnesota, Olmsted County'de 50 yafl›n üzerindeki bireylerde DHA'n›n y›ll›k insidans› ‹skandinav ülkelerindekine benzer flekilde yaklafl›k olarak 17/100.000 olarak saptanm›flt›r. [4] Türkiye'den bildirilen tek çal›flmada ise DHA'n›n 50 yafl üstü y›ll›k insidans› 1.13/100.000 olarak saptanm›flt›r. [5] DHA'n›n Gü-ney Avrupa ve Akdeniz ülkelerinde 50 yafl›n üzerindeki insidans› 10/100.000'den daha düflüktür.…”

Section: Abstract: Giant Cell Arteritis Temporal Arteritis Vasculitisunclassified

Giant cell (temporal) arteritis

Balcı¹,

Pamuk²

2015

RAED Derg

View full text Add to dashboard Cite

“…Giant cell arteritis (GCA) is the most common vasculitis in Western countries among individuals 50 years and older 1 . This medium and large-vessel granulomatous vasculitis typically affects the extracranial branches of the carotid artery 1 .…”

mentioning

confidence: 99%