2005
DOI: 10.1007/s10517-005-0433-9
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NO-Dependent Mechanism of Adrenergic Reaction of Systemic Hemodynamics

Abstract: Blockade of NO synthesis in narcotized rats potentiated pressor effects of phenylephrine by 55% and increased total peripheral resistance by 153%. Vasodilation caused by enhanced NO secretion modulated pressor shifts evoked by stimulation of alpha(1)-adrenoceptors with phenylephrine.

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“…Elimination of NO-dependent vasodilation increases the degree of changes in blood pressure (BP) and total peripheral resistance (TPR) after stimulation of α 1 -adrenoceptors in rats [4].…”
mentioning
confidence: 99%
“…Elimination of NO-dependent vasodilation increases the degree of changes in blood pressure (BP) and total peripheral resistance (TPR) after stimulation of α 1 -adrenoceptors in rats [4].…”
mentioning
confidence: 99%