Role of NO in the systemic hemodynamic response to β2-adrenoceptor stimulation

Abstract

Blockade of NO synthesis in most narcotized rats was followed by an increase in depressor effects (by 45%) and decrease in total peripheral resistance (by 63%) upon treatment with isopropyl norepinephrine (isoproterenol). Our results indicate that NO secretion in the endothelium modulates the systemic hemodynamic response to beta(2)-adrenoceptor stimulation.