No cure of HIV infection in a child despite early treatment and apparent viral clearance

Giacomet, Vania; Trabattoni, Daria; Zanchetta, Nadia; Biasin, Mara; Gismondo, M.R.; Clerici, Mario; Zuccotti, Gianvincenzo

doi:10.1016/s0140-6736(14)61405-7

Cited by 52 publications

(32 citation statements)

References 5 publications

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“…Whether earlier initiation or a longer duration of ART, alone or combined with immunotherapeutic strategies, would have further extended the duration of remission is unknown. Although unfortunate for this child, the findings in this case and others 6, 7 provide important new information on how very early treatment may markedly restrict but not eradicate HIV-1 reservoirs. Additional studies are underway to test this hypothesis and to determine whether ART alone will enable long-term HIV-1 remission or cure.…”

mentioning

confidence: 59%

Viremic Relapse after HIV-1 Remission in a Perinatally Infected Child

Luzuriaga¹,

Gay²,

Ziemniak³

et al. 2015

N Engl J Med

230

178

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mentioning

confidence: 59%

Viremic Relapse after HIV-1 Remission in a Perinatally Infected Child

Luzuriaga¹,

Gay²,

Ziemniak³

et al. 2015

N Engl J Med

230

178

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“…However, the youngest age at starting ART in our cohort was 3 weeks of age and a sizable proportion of the cohort had recorded intermittent viremia after suppression, perhaps explaining why the proportion testing negative was not higher than has been reported in infants starting ART within days of birth. 5–11 …”

Section: Discussionmentioning

confidence: 99%

“…8 The recent case reports of early-treated children have also reported negative HIV antibody results during suppressive ART. 9–11 …”

Section: Introductionmentioning

confidence: 99%

Young age at start of antiretroviral therapy and negative HIV antibody results in HIV-infected children when suppressed

Kuhn

Schramm²,

Shiau

et al. 2015

Aids

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Background Negative results on standard HIV antibody tests have been described among HIV-infected children suppressed on antiretroviral therapy (ART) started early in life. Here we describe the frequency and predictors of this phenomenon in a well-characterized cohort of treated children. Methods We selected samples from 103 HIV-infected children who started ART ≤ 14 months of age and from 122 children who started ≤ 6 months of age followed as part of two sequential clinical trials in Johannesburg, South Africa. Children had attained viral suppression on ART and had received ART for between 3 and 6.4 years (mean 4.3 years) when tested for HIV antibody using a standard ELISA (Genescreen™ HIV1/2 version 2; Bio-rad). Results Only children ≤6 months of age when ART was started had negative antibody results when tested after suppression on ART several years later. Negative or low-positive antibody results were observed in 40.0%, 37.0% and 27.8% of children starting ART <2 months of age, or starting during month 2 or 3, respectively. This dropped to 5.9%, 3.5%, and 5.3% if ART was started during month 4, 5, and 6, respectively. Higher CD4 percentage prior to ART initiation and no recorded intermittent viremia also predicted negative antibody results. Conclusion Testing negative on standard HIV antibody tests occurs fairly commonly among HIV-infected children who started ART ≤ 3 months of age and are virally-suppressed. It would be prudent in clinical practice to avoid HIV antibody tests among virally-suppressed, early-treated children to prevent unnecessary confusion.

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“…For why there are such results, some scholars believe that may be infected at early ,ART can prevent the formation of HIV storage pool or limit the size of it [18] , so that patients can get longer controlling virus after stopping the drug. Therefore, as soon as possible and effective ART therapy to treat HIV-infected patients early still has important value [19] .…”

Section: Curable Case Of Aidsmentioning

confidence: 99%

The Research Progress of the Fuctional Cure of AIDS

Xu¹,

Luo²

2015

J. Appl. Virol.

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Acquired Immune Deficiency Syndrome remains incurable even though it has been more than thirty years since first discovered in 1981. Highly Active Anti-retroviral Therapy provides effective treatment to AIDS patients. However, Human Immunodeficiency Virus will rebound due to the existence of the latent viral reservoir if Active Anti-retroviral Therapy (ART) interrupted. Functional cure refers to keep viral load at low or undetectable level (at least for a certain period of time) after interrupting antiretroviral treatment. This brief review focuses on the achievement in functional cure of AIDS.

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No cure of HIV infection in a child despite early treatment and apparent viral clearance

Cited by 52 publications

References 5 publications

Viremic Relapse after HIV-1 Remission in a Perinatally Infected Child

Viremic Relapse after HIV-1 Remission in a Perinatally Infected Child

Young age at start of antiretroviral therapy and negative HIV antibody results in HIV-infected children when suppressed

The Research Progress of the Fuctional Cure of AIDS

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