No correlation between glucose metabolism and apparent diffusion coefficient in diffuse large B-cell lymphoma: A PET/CT and DW-MRI study

Wu, Xingchen; Korkola, Pasi; Pertovaara, Hannu; Eskola, Hannu; Järvenpää, Ritva; Kellokumpu-Lehtinen, Pirkko-Liisa

doi:10.1016/j.ejrad.2011.04.062

Cited by 36 publications

(30 citation statements)

References 19 publications

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“…Yet, in contrary to the publication of Ho et al, only revealing a significant correlation of the ratio of SUV max and ADC min , our data analysis showed a direct significant correlation of the two parameters [33]. This controversial correlation between the two biomarkers has been well-recognized in numerous trials, investigating diverse tumor entities and may be caused by a number of altering conditions [41], [42]. One reason for differing correlations may lie in the timing of the performed PET and MRI examinations.…”

Section: Discussioncontrasting

confidence: 99%

Correlation of Standardized Uptake Value and Apparent Diffusion Coefficient in Integrated Whole-Body PET/MRI of Primary and Recurrent Cervical Cancer

et al. 2014

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BackgroundTo evaluate a potential correlation of the maximum standard uptake value (SUVmax) and the minimum apparent diffusion coefficient (ADCmin) in primary and recurrent cervical cancer based on integrated PET/MRI examinations.Methods19 consecutive patients (mean age 51.6 years; range 30–72 years) with histopathologically confirmed primary cervical cancer (n = 9) or suspected tumor recurrence (n = 10) were prospectively enrolled for an integrated PET/MRI examination. Two radiologists performed a consensus reading in random order, using a dedicated post-processing software. Polygonal regions of interest (ROI) covering the entire tumor lesions were drawn into PET/MR images to assess SUVmax and into ADC parameter maps to determine ADCmin values. Pearson’s correlation coefficients were calculated to assess a potential correlation between the mean values of ADCmin and SUVmax.ResultsIn 15 out of 19 patients cervical cancer lesions (n = 12) or lymph node metastases (n = 42) were detected. Mean SUVmax (12.5±6.5) and ADCmin (644.5±179.7×10−5 mm2/s) values for all assessed tumor lesions showed a significant but weak inverse correlation (R = −0.342, p<0.05). When subdivided in primary and recurrent tumors, primary tumors and associated primary lymph node metastases revealed a significant and strong inverse correlation between SUVmax and ADCmin (R = −0.692, p<0.001), whereas recurrent cancer lesions did not show a significant correlation.ConclusionsThese initial results of this emerging hybrid imaging technique demonstrate the high diagnostic potential of simultaneous PET/MR imaging for the assessment of functional biomarkers, revealing a significant and strong correlation of tumor metabolism and higher cellularity in cervical cancer lesions.

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Section: Discussioncontrasting

confidence: 99%

Correlation of Standardized Uptake Value and Apparent Diffusion Coefficient in Integrated Whole-Body PET/MRI of Primary and Recurrent Cervical Cancer

et al. 2014

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“…The ability to simultaneously measure ADC and SUV max with a hybrid PET/MRI system ensures that these measurements are performed under identical conditions. Although this weak correlation between ADC and SUV max may be partly secondary to a mixed treatment population, previous studies of lymphoma patients have shown moderate to poor inverse correlation [9] and no correlation [18, 19] between these two parameters. A weak correlation or no correlation has also been noted in numerous nonlymphoma malignancies [12, 20–22].…”

Section: Discussionmentioning

confidence: 93%

PET/MRI for the Evaluation of Patients With Lymphoma: Initial Observations

Heacock

Weissbrot

Raad

et al. 2015

American Journal of Roentgenology

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OBJECTIVE The objective of our study was to assess the role of recently introduced hybrid PET/MRI in the evaluation of lymphoma patients using PET/CT as a reference standard. SUBJECTS AND METHODS In this prospective study 28 consecutive lymphoma patients (18 men, 10 women; mean age, 53.6 years) undergoing clinically indicated PET/ CT were subsequently imaged with PET/MRI using residual FDG activity from the PET/ CT study. Blinded readers evaluated PET/CT (reference standard), PET/MRI, and diffusion-weighted imaging (DWI) studies separately; for each study, they assessed nodal and extranodal involvement. Each FDG-avid nodal station was marked and compared on DWI, PET/MRI, and PET/CT. Modified Ann Arbor staging was performed and compared between PET/MRI and PET/CT. The maximum standardized uptake value (SUVmax) on PET/MRI for FDG-avid nodal lesions was compared with the SUVmax on PET/CT. The apparent diffusion coefficient (ADC) for FDG-avid nodal lesions was compared to SUVmax on PET/MRI. RESULTS Fifty-one FDG-avid nodal groups were identified on PET/CT in 13 patients. PET/MRI identified 51 of these nodal groups with a sensitivity of 100%. DWI identified 32 nodal groups for a sensitivity of 62.7%. PET/MRI staging and PET/CT staging were concordant in 96.4% of patients. For the one patient with discordant staging results, disease was correctly upstaged to stage IV on the basis of the PET/MRI finding of bone marrow involvement, which was missed on PET/CT. DWI staging was concordant with PET/CT staging in 64.3% of the patients. The increased staging accuracy of PET/MRI relative to DWI was significant (p = 0.004). SUVmax measured on PET/MRI and PET/CT showed excellent statistically significant correlation (r = 0.98, p < 0.001). There was a poor negative correlation between ADC and SUVmax (r = −0.036, p = 0.847). CONCLUSION PET/MRI can be used to assess disease burden in lymphoma with sensitivity similar to PET/CT and can be a viable alternative for lymphoma staging and follow-up.

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“…24 Another study of head-and-neck patients reported no correlation between FDG uptake and ADC 25 ; however, other researchers have reported reverse correlation between minimum ADC and SUV max in the evaluation of lung lesions. 26,27 In the present study, the mean ADC for the lesion was chosen, as the majority of studies employ this approach in determining the ADC value.…”

Section: Figurementioning

confidence: 97%

Whole-body diffusion-weighted MRI and 18F-FDG PET/CT can discriminate between different lymphoma subtypes

Mosavi

Wassberg

Selling³

et al. 2015

Clinical Radiology

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No correlation between glucose metabolism and apparent diffusion coefficient in diffuse large B-cell lymphoma: A PET/CT and DW-MRI study

Cited by 36 publications

References 19 publications

Correlation of Standardized Uptake Value and Apparent Diffusion Coefficient in Integrated Whole-Body PET/MRI of Primary and Recurrent Cervical Cancer

Correlation of Standardized Uptake Value and Apparent Diffusion Coefficient in Integrated Whole-Body PET/MRI of Primary and Recurrent Cervical Cancer

PET/MRI for the Evaluation of Patients With Lymphoma: Initial Observations

Whole-body diffusion-weighted MRI and 18F-FDG PET/CT can discriminate between different lymphoma subtypes

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